Biosensors and Bioelectronics, Год журнала: 2025, Номер unknown, С. 117461 - 117461
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Nano-Phytoconstituents: Recent Advances, Regulatory Insights, Challenges, and Future Horizons
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106908 - 106908
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Cell Death Mechanisms Produced by Carbon‐Based Nanoparticles
Journal of Nanotechnology, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
Using carbon‐based nanoparticles, such as diamond, graphite, fullerene, and nanotubes, has increased their research possible strategies for drug delivery to control diseases, especially cancer. However, because these materials, when interacting with the living environment, release substances that are capable of inducing cell death by themselves, it is vital importance analyze type particle can induce. Although there different efforts describe kind nanoparticles used treat diseases cancer, no paper explains mechanisms induced nanoparticle systems. Therefore, this attempts gain cutting‐edge information on using nanopolymorphisms mechanism particles produce. In conclusion, carbon interact directly membranes, causing physical damage disturbing integrity membrane. This alteration mainly lead necrosis or apoptosis. The definition a predominant each depends dose‐dependent manner. Primarily, concentrations cytotoxicity were 100–500 μg/mL. several studies analyzed, was only find nanodiamonds proved not be cytotoxic.
Язык: Английский
Процитировано
0Insights into nanostructured lipid carriers of etoricoxib for mitigating radiation‐induced lung inflammation and exploring anti‐inflammatory mechanisms in rats
Fundamental and Clinical Pharmacology, Год журнала: 2025, Номер 39(3)
Опубликована: Май 5, 2025
Abstract Background Radiation exposure can cause inflammation, which etoricoxib (ET), an anti‐inflammatory drug, could potentially mitigate. Objective This study aimed to evaluate the potential effectiveness of etoricoxib‐loaded nanostructured lipid carriers (ET‐NLCs) in mitigating radiation‐induced acute lung inflammation rats. Methods Thirty‐six rats were divided into six groups. Group 1 (C): control; group 2 (ET): normal given ET (10 mg/kg) orally for 14 days; 3 (ET‐NLC): administered ET‐NLCs days. 4 (R): exposed 6 Gy whole‐body gamma radiation, untreated thereafter induce and injury. 5 (ET‐R), irradiated rats, daily (ET‐NLC‐R), Molecular, biochemical, histopathological analyses performed assess apoptosis, oxidative stress, tissue architecture. Results led a 1053% increase Bax expression 81.5% decrease Bcl‐2, indicating heightened apoptosis. treatment reversed these effects, reducing by 59.9% increasing Bcl‐2 337.4%. Additionally, reduced caspase‐3 caspase‐8 activation 54.5% 62.9%, respectively, compared radiation alone. Furthermore, demonstrated potent effects interleukin‐6 (IL‐6) tumor necrosis factor‐alpha (TNF‐α) levels 49% 39%, group. increased malondialdehyde (MDA) 388%, damage, suppressed antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD). ET‐NLC decreased MDA CAT, GPX, SOD 35.7%, 4766.7%, 765.9%, restoring balance. surfactant protein (SP‐D) 4.9% control values, but restored them 14%. Histopathological analysis revealed that radiation‐exposed lungs showed thickened inter‐alveolar septa, emphysematous areas, inflammatory infiltration. exhibited only mild thickening limited cell infiltration, suggesting significant improvement Conclusions Based on results, NLCs are one most promising ways deliver drugs treating damage caused radiation.
Язык: Английский
Процитировано
0Recent advances in targeted therapy on cancers by nanoparticles encapsulated in exosomes: a comprehensive review
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 107033 - 107033
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Metal Nanoparticles in Liver Cancer Therapy: Advances, Challenges, and Future Directions
Next research., Год журнала: 2025, Номер unknown, С. 100421 - 100421
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Exploring the anticancer and antioxidant potential of gold nanoparticles synthesized from Pterocarpus marsupium bark extract against oral squamous cell carcinoma
Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2024, Номер 52(1), С. 512 - 528
Опубликована: Окт. 25, 2024
Oral squamous cell carcinoma (OSCC) is a disease of significant concern with higher mortality rates. Conventional treatment approaches have several drawbacks, leading to the opening new research avenues in field nanoparticle-based cancer therapeutics. The study aimed at synthesis gold nanoparticles (Pm-AuNPs) from aqueous bark extract Pterocarpus marsupium, followed by its characterization and vitro anticancer evaluation against OSCC. synthesized Pm-AuNPs were characterized using UV–visible spectroscopy, particle size analyser, zeta potential, FTIR SEM techniques. potential was evaluated OSCC lines (SCC29b, SSC154 OECM-1) through assays. IC50 value found be 25 ± 1.2, 45 1.5 75 2.1 µg/mL for three lines, elucidating cytotoxic effects mechanism action. Intracellular ROS SOX detection, mitochondrial transmembrane analysis apoptosis detection used confirm activity Acute toxicity studies on Wistar rats confirmed non-toxic nature dose concentration up 2000 mg/kg body weight. findings underscore as promising candidates future therapeutics, providing insights into their action therapeutic efficacy
Язык: Английский
Процитировано
2Enhancing cancer therapy: advanced nanovehicle delivery systems for oridonin
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 3, 2024
Oridonin (ORI), an ent-kaurane diterpenoid derived from Rabdosia rubescens (Hemsl.) H.Hara, serves as the primary bioactive component of this plant. It demonstrates a broad spectrum therapeutic activities, including moderate to potent anticancer properties, alongside anti-inflammatory, antibacterial, antifibrotic, immunomodulatory, and neuromodulatory effects, thus influencing diverse biological processes. However, its clinical potential is significantly constrained by poor aqueous solubility limited bioavailability. In alignment with approach developing drug candidates natural compounds, various strategies, such structural modification nanocarrier systems, have been employed address these challenges. This review provides overview ORI-based nano-delivery emphasizing their improve applicability oridonin in oncology. Although some progress has made advancing ORI research, it remains insufficient for implementation, necessitating further investigation.
Язык: Английский
Процитировано
1Donafenib inhibits PARP1 expression and induces DNA damage, in combination with PARP1 inhibitors promotes apoptosis in liver cancer cells
Anti-Cancer Drugs, Год журнала: 2024, Номер 35(9), С. 789 - 805
Опубликована: Июнь 26, 2024
Liver cancer is a prevalent malignant tumor globally. The newly approved first-line drug, donafenib, novel oral small molecule multi-tyrosine kinase inhibitor that has significant antitumor effects on liver cancer. This study aims to investigate the of donafenib and explore its potential mechanisms. Donafenib significantly inhibited viability Huh-7 HCCLM3 cells, cell proliferation, promoted apoptosis, as demonstrated by CCK-8, EdU, Calcein/PI (propidium iodide) staining experiments. results DNA damage detection experiments western blot analysis indicate caused considerable in cells. poly (ADP-ribose) polymerase 1 (PARP1) patients using online bioinformatics data websites such TIMER2.0, GEPIA, UALCAN, cBioPortal, Kaplan-Meier Plotter, HPA revealed high expression PARP1, which associated with poor prognosis. Molecular docking can directly target downregulate protein repair protein, thereby promoting Western immunofluorescence showed group treated combined PARP1 had higher γ-H2AX 8-OHdG compared groups or inhibitors alone, treatment suppresses antiapoptotic Bcl2 enhances level proapoptotic Bcl-2-associated X (BAX). These suggest combination more cells promotes apoptosis. Thus, be option for
Язык: Английский
Процитировано
0Enhancing Chordoma Radiotherapy: Ta@PVP Nanoparticles as Potent Radiosensitizers
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown
Опубликована: Дек. 18, 2024
Surgical resection and high-dose radiotherapy constitute the standard therapeutic approaches for chordoma. However, efficacy of is often compromised by tumor microenvironment's hypoxic conditions, which confer radiation resistance, potential damage to adjacent spinal cord neural structures from elevated doses. To address these challenges, we employed high biocompatible poly(vinylpyrrolidone)-modified tantalum nanoparticles (Ta@PVP NPs) as a potent radiosensitizer augment sensitivity Upon exposure X-ray irradiation, Ta@PVP NPs demonstrated capability efficiently deposit energy within microenvironment, subsequently generating reactive oxygen species (ROS) that induce oxidative stress in tumor. Both vitro vivo experiments revealed significantly enhanced cytotoxic effects X-ray, thereby markedly inhibiting proliferation chordoma cells impeding growth. This study explored radiosensitization context chordoma, highlighting application radiosensitizers promising strategy radiotherapy.
Язык: Английский
Процитировано
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