Stabilization and enhanced anticancer activity of zinc oxide nanoparticles functionalized with chitosan and terephthalic acid

Journal of Sol-Gel Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

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Confining metal nanoparticles and nanoclusters in covalent organic frameworks for biosensing and biomedicine

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117461 - 117461

Published: April 1, 2025

Language: Английский

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Nano-Phytoconstituents: Recent Advances, Regulatory Insights, Challenges, and Future Horizons

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106908 - 106908

Published: April 1, 2025

Language: Английский

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Insights into nanostructured lipid carriers of etoricoxib for mitigating radiation‐induced lung inflammation and exploring anti‐inflammatory mechanisms in rats

Fundamental and Clinical Pharmacology, Journal Year: 2025, Volume and Issue: 39(3)

Published: May 5, 2025

Abstract Background Radiation exposure can cause inflammation, which etoricoxib (ET), an anti‐inflammatory drug, could potentially mitigate. Objective This study aimed to evaluate the potential effectiveness of etoricoxib‐loaded nanostructured lipid carriers (ET‐NLCs) in mitigating radiation‐induced acute lung inflammation rats. Methods Thirty‐six rats were divided into six groups. Group 1 (C): control; group 2 (ET): normal given ET (10 mg/kg) orally for 14 days; 3 (ET‐NLC): administered ET‐NLCs days. 4 (R): exposed 6 Gy whole‐body gamma radiation, untreated thereafter induce and injury. 5 (ET‐R), irradiated rats, daily (ET‐NLC‐R), Molecular, biochemical, histopathological analyses performed assess apoptosis, oxidative stress, tissue architecture. Results led a 1053% increase Bax expression 81.5% decrease Bcl‐2, indicating heightened apoptosis. treatment reversed these effects, reducing by 59.9% increasing Bcl‐2 337.4%. Additionally, reduced caspase‐3 caspase‐8 activation 54.5% 62.9%, respectively, compared radiation alone. Furthermore, demonstrated potent effects interleukin‐6 (IL‐6) tumor necrosis factor‐alpha (TNF‐α) levels 49% 39%, group. increased malondialdehyde (MDA) 388%, damage, suppressed antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD). ET‐NLC decreased MDA CAT, GPX, SOD 35.7%, 4766.7%, 765.9%, restoring balance. surfactant protein (SP‐D) 4.9% control values, but restored them 14%. Histopathological analysis revealed that radiation‐exposed lungs showed thickened inter‐alveolar septa, emphysematous areas, inflammatory infiltration. exhibited only mild thickening limited cell infiltration, suggesting significant improvement Conclusions Based on results, NLCs are one most promising ways deliver drugs treating damage caused radiation.

Language: Английский

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Exploring the anticancer and antioxidant potential of gold nanoparticles synthesized from Pterocarpus marsupium bark extract against oral squamous cell carcinoma

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 512 - 528

Published: Oct. 25, 2024

Oral squamous cell carcinoma (OSCC) is a disease of significant concern with higher mortality rates. Conventional treatment approaches have several drawbacks, leading to the opening new research avenues in field nanoparticle-based cancer therapeutics. The study aimed at synthesis gold nanoparticles (Pm-AuNPs) from aqueous bark extract Pterocarpus marsupium, followed by its characterization and vitro anticancer evaluation against OSCC. synthesized Pm-AuNPs were characterized using UV–visible spectroscopy, particle size analyser, zeta potential, FTIR SEM techniques. potential was evaluated OSCC lines (SCC29b, SSC154 OECM-1) through assays. IC50 value found be 25 ± 1.2, 45 1.5 75 2.1 µg/mL for three lines, elucidating cytotoxic effects mechanism action. Intracellular ROS SOX detection, mitochondrial transmembrane analysis apoptosis detection used confirm activity Acute toxicity studies on Wistar rats confirmed non-toxic nature dose concentration up 2000 mg/kg body weight. findings underscore as promising candidates future therapeutics, providing insights into their action therapeutic efficacy

Language: Английский

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Enhancing cancer therapy: advanced nanovehicle delivery systems for oridonin

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Oridonin (ORI), an ent-kaurane diterpenoid derived from Rabdosia rubescens (Hemsl.) H.Hara, serves as the primary bioactive component of this plant. It demonstrates a broad spectrum therapeutic activities, including moderate to potent anticancer properties, alongside anti-inflammatory, antibacterial, antifibrotic, immunomodulatory, and neuromodulatory effects, thus influencing diverse biological processes. However, its clinical potential is significantly constrained by poor aqueous solubility limited bioavailability. In alignment with approach developing drug candidates natural compounds, various strategies, such structural modification nanocarrier systems, have been employed address these challenges. This review provides overview ORI-based nano-delivery emphasizing their improve applicability oridonin in oncology. Although some progress has made advancing ORI research, it remains insufficient for implementation, necessitating further investigation.

Language: Английский

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Donafenib inhibits PARP1 expression and induces DNA damage, in combination with PARP1 inhibitors promotes apoptosis in liver cancer cells

Anti-Cancer Drugs, Journal Year: 2024, Volume and Issue: 35(9), P. 789 - 805

Published: June 26, 2024

Liver cancer is a prevalent malignant tumor globally. The newly approved first-line drug, donafenib, novel oral small molecule multi-tyrosine kinase inhibitor that has significant antitumor effects on liver cancer. This study aims to investigate the of donafenib and explore its potential mechanisms. Donafenib significantly inhibited viability Huh-7 HCCLM3 cells, cell proliferation, promoted apoptosis, as demonstrated by CCK-8, EdU, Calcein/PI (propidium iodide) staining experiments. results DNA damage detection experiments western blot analysis indicate caused considerable in cells. poly (ADP-ribose) polymerase 1 (PARP1) patients using online bioinformatics data websites such TIMER2.0, GEPIA, UALCAN, cBioPortal, Kaplan-Meier Plotter, HPA revealed high expression PARP1, which associated with poor prognosis. Molecular docking can directly target downregulate protein repair protein, thereby promoting Western immunofluorescence showed group treated combined PARP1 had higher γ-H2AX 8-OHdG compared groups or inhibitors alone, treatment suppresses antiapoptotic Bcl2 enhances level proapoptotic Bcl-2-associated X (BAX). These suggest combination more cells promotes apoptosis. Thus, be option for

Language: Английский

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Enhancing Chordoma Radiotherapy: Ta@PVP Nanoparticles as Potent Radiosensitizers

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Surgical resection and high-dose radiotherapy constitute the standard therapeutic approaches for chordoma. However, efficacy of is often compromised by tumor microenvironment's hypoxic conditions, which confer radiation resistance, potential damage to adjacent spinal cord neural structures from elevated doses. To address these challenges, we employed high biocompatible poly(vinylpyrrolidone)-modified tantalum nanoparticles (Ta@PVP NPs) as a potent radiosensitizer augment sensitivity Upon exposure X-ray irradiation, Ta@PVP NPs demonstrated capability efficiently deposit energy within microenvironment, subsequently generating reactive oxygen species (ROS) that induce oxidative stress in tumor. Both vitro vivo experiments revealed significantly enhanced cytotoxic effects X-ray, thereby markedly inhibiting proliferation chordoma cells impeding growth. This study explored radiosensitization context chordoma, highlighting application radiosensitizers promising strategy radiotherapy.

Language: Английский

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Metabolic-Modulating Effects of Radiation: Undetectable Yet Deadly—A Review on Radiotherapy

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 54 - 54

Published: Dec. 27, 2024

From a cancer-centric perspective, radiotherapy has been primarily viewed as localised treatment modality, targeting cancer tissues with ionising radiation to induce DNA damage and cell death [...]

Language: Английский

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Green synthesis and characterization of CuO/ZnO nanocomposite using Musa acuminata leaf extract for cytotoxic studies on colorectal cancer cells (HCC2998)

Green Processing and Synthesis, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract Green synthesis has become an alternative to replace chemical in nanotechnology because of its low cost and toxicity. The nanocomposite (NC) attracted the attention researchers, as synergistic effect might enhance effectiveness anticancer overcome multidrug resistance. In this study, copper oxide/zinc oxide (CuO/ZnO) NC was green synthesized from crude extract Musa acuminata leaves with Zn(NO 3 ) 2 ·6H O Cu(NO ·3H precursors. CuO/ZnO characterized via UV-Vis analysis a peak detected at 365 nm bandgap energy 3.43 eV. Field emission scanning electron microscopy showed agglomerated, irregular shape size ranging 31.8 85.7 nm. X-ray diffraction depicted crystallite 24.78 hexagonal wurtzite ZnO monoclinic CuO. Fourier transform infrared spectroscopy presence functional groups, including hydroxyl carbonyl amines, alkanes, aromatic Cu–O, Zn–O. cytotoxic toward colorectal cancer cells (HCC2998) evaluated by MTT assay found be dose-dependent. results significant cell mortality 100 µg·mL −1 45.79% death 24 h. findings present study suggest potential utilized agent.

Language: Английский

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