Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(2)
Опубликована: Дек. 4, 2024
Abstract
Cancer
treatment
has
witnessed
revolutionary
advancements
marked
by
the
emergence
of
immunotherapy,
specifically
immune
checkpoint
blockade
(ICB).
However,
inherent
low
immunogenicity
tumor
cells
and
intricate
immunosuppressive
network
within
microenvironment
(TME)
pose
significant
challenges
to
further
development
immunotherapy.
Nanotechnology
ushered
in
unprecedented
opportunities
vast
prospects
for
Nevertheless,
traditional
nano‐formulations
often
rely
on
inducing
apoptosis
kill
cancer
cells,
which
encounters
issue
silencing,
hindering
effective
activation.
The
non‐apoptotic
modes
regulated
cell
death
(RCD),
including
pyroptosis,
ferroptosis,
autophagy,
necroptosis,
cuproptosis,
have
gradually
garnered
attention.
These
pathways
can
induce
immunogenic
(ICD),
enhancing
This
review
comprehensively
explores
advanced
nano‐formulation
design
strategies
their
applications
immunotherapy
promoting
RCD
recent
years.
It
also
discusses
potential
advantages
these
tumor‐specific
RCD.
By
deeply
understanding
significance
synergistic
this
article
provides
valuable
insights
developing
more
nano‐delivery
systems
that
robustly
highly
modes,
offering
novel
research
avenues
address
clinical
encountered
represented
ICB.
MedMat.,
Год журнала:
2024,
Номер
1(2), С. 74 - 94
Опубликована: Дек. 1, 2024
Cuproptosis,
a
newly
discovered
copper-dependent
mode
of
cell
death,
has
received
extensive
attention
in
the
field
cancer
therapy
due
to
its
specific
activation
pathway.
Rapid
accumulation
large
amounts
copper
ions
within
cells
achieve
overload
is
key
activating
cuproptosis.
Advanced
nanotechnology
offers
considerable
promise
for
delivering
cells,
which
copper-based
nanomaterials
have
been
proposed
evoke
cuproptosis-mediated
therapy.
However,
it
still
great
challenge
induce
specifically
tumors
and
efficiently
activate
subsequent
cuproptosis-related
molecular
pathways.
Therefore,
necessary
summarize
strategies
used
effectively
or
amplify
cuproptosis
based
on
currently
developed
nanomaterials,
providing
ideas
design
future.
In
this
review,
that
can
be
are
systematically
classified
selection.
Subsequently,
sensitization
using
provided
therapeutic
efficiency.
Meanwhile,
combination
therapies
maximizing
treatment
efficacy
delineated.
Ultimately,
remaining
challenges
feasible
future
directions
use
tumor
also
discussed.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(2)
Опубликована: Дек. 4, 2024
Abstract
Cancer
treatment
has
witnessed
revolutionary
advancements
marked
by
the
emergence
of
immunotherapy,
specifically
immune
checkpoint
blockade
(ICB).
However,
inherent
low
immunogenicity
tumor
cells
and
intricate
immunosuppressive
network
within
microenvironment
(TME)
pose
significant
challenges
to
further
development
immunotherapy.
Nanotechnology
ushered
in
unprecedented
opportunities
vast
prospects
for
Nevertheless,
traditional
nano‐formulations
often
rely
on
inducing
apoptosis
kill
cancer
cells,
which
encounters
issue
silencing,
hindering
effective
activation.
The
non‐apoptotic
modes
regulated
cell
death
(RCD),
including
pyroptosis,
ferroptosis,
autophagy,
necroptosis,
cuproptosis,
have
gradually
garnered
attention.
These
pathways
can
induce
immunogenic
(ICD),
enhancing
This
review
comprehensively
explores
advanced
nano‐formulation
design
strategies
their
applications
immunotherapy
promoting
RCD
recent
years.
It
also
discusses
potential
advantages
these
tumor‐specific
RCD.
By
deeply
understanding
significance
synergistic
this
article
provides
valuable
insights
developing
more
nano‐delivery
systems
that
robustly
highly
modes,
offering
novel
research
avenues
address
clinical
encountered
represented
ICB.
