Molecules, Год журнала: 2024, Номер 29(23), С. 5764 - 5764
Опубликована: Дек. 6, 2024
In this study, homoisoflavone methylophiopogonanone A (MOA) was investigated for its inhibitory effect on ferroptosis of H9c2 cells using a set cellular assays, such as BODIPY-probed and H
Язык: Английский
Phytomedicine, Год журнала: 2025, Номер unknown, С. 156783 - 156783
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Functional Foods, Год журнала: 2024, Номер 121, С. 106437 - 106437
Опубликована: Сен. 1, 2024
Hepatotoxicity is an significant side effect of doxorubicin (DOX), while astaxanthin (ASX) has the anti-liver injury biological functions. In this study, we utilized in vivo and vitro methods to investigate protective ASX against DOX-induced hepatotoxicity elucidate its potential mechanism. Our researchers measured liver indicators expression ferroptosis-related protein (transferrin receptor 1 (TFRC), ferroportin (FPN1), ferritin light chain (FTL), heavy chain-1 (FTH1), glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11)) rats HepG2 cells. We found that could effectively reduce ferroptosis level relieve a range DOX-caused manifestations injury, including inflammation oxidative damage. may play same role as inhibitor, Fer-1 DFP, process. The findings demonstrated intervention with ameliorated by mitigating through inhibiting iron accumulation.
Язык: Английский
Процитировано
2
Biology, Год журнала: 2024, Номер 13(9), С. 689 - 689
Опубликована: Сен. 3, 2024
Anthracyclines represent a highly efficacious class of chemotherapeutic agents employed extensively in antitumor therapy. They are universally recognized for their potency treating diverse malignancies, encompassing breast cancer, gastrointestinal tumors, and lymphomas. Nevertheless, the accumulation anthracyclines within body can lead to significant cardiac toxicity, adversely impacting both survival rates quality life tumor patients. This limitation somewhat restricts clinical utilization. Determining how monitor mitigate cardiotoxicity at an early stage has become urgent problem be solved. Therefore, this paper reviews mechanism action, monitoring, strategies prevention anthracycline-induced reference.
Язык: Английский
Процитировано
2
Biomaterials Advances, Год журнала: 2024, Номер 167, С. 214114 - 214114
Опубликована: Ноя. 12, 2024
Язык: Английский
Процитировано
2
Journal of Applied Toxicology, Год журнала: 2024, Номер unknown
Опубликована: Июль 18, 2024
Abstract Doxorubicin (DOX) is a chemotherapy drug widely used in clinical settings, acting as first‐line treatment for various malignant tumors. However, its use greatly limited by the cardiotoxicity it induces, including doxorubicin‐induced cardiomyopathy (DIC). The mechanisms behind DIC are not fully understood, but potential biological thought to include oxidative stress, inflammation, energy metabolism disorders, mitochondrial damage, autophagy, apoptosis, and ferroptosis. Recent studies have shown that cardiac injury induced DOX closely related Due their high efficacy, availability, low side effects, natural medicine treatments hold strong potential. Currently, medicines been mitigate DOX‐induced ferroptosis ease through functions such antioxidation, iron ion homeostasis correction, lipid regulation, function improvement. Therefore, this review summarizes of regulation plant products, with expectation providing reference future research development inhibitors targeting DIC. This explores (DIC) how products can alleviate inhibiting reducing correcting homeostasis, regulating metabolism, improving function.
Язык: Английский
Процитировано
1
Free Radical Biology and Medicine, Год журнала: 2024, Номер 227, С. 129 - 142
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2024, Номер 14(12), С. 1614 - 1614
Опубликована: Дек. 17, 2024
Doxorubicin is a chemotherapeutic drug utilized for solid tumors and hematologic malignancies, but its clinical application hampered by life-threatening cardiotoxicity, including cardiac dilation heart failure. Mitophagy, cargo-specific form of autophagy, specifically used to eliminate damaged mitochondria in autophagosomes through hydrolytic degradation following fusion with lysosomes. Recent advances have unveiled major role defective mitophagy the etiology DOX-induced cardiotoxicity. Moreover, specific interventions targeting this mechanism preserve mitochondrial function emerged as potential therapeutic strategies attenuate However, translation challenging because unclear mechanisms action pharmacological adverse effects. This review aims offer fresh perspectives on development cardiotoxicity investigate that focus improve management.
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Окт. 4, 2024
Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2024, Номер 340, С. 119146 - 119146
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2024, Номер 29(23), С. 5764 - 5764
Опубликована: Дек. 6, 2024
In this study, homoisoflavone methylophiopogonanone A (MOA) was investigated for its inhibitory effect on ferroptosis of H9c2 cells using a set cellular assays, such as BODIPY-probed and H
Язык: Английский
Процитировано
0