Brain-tumor-seeking and serpin-inhibiting outer membrane vesicles restore plasmin-mediated attacks against brain metastases
Journal of Controlled Release,
Год журнала:
2024,
Номер
375, С. 116 - 126
Опубликована: Сен. 6, 2024
Язык: Английский
GRP94 mediates blood-brain barrier permeation and substantia nigra-specific drug distribution in Parkinson’s disease
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
unknown, С. 114585 - 114585
Опубликована: Фев. 1, 2025
Язык: Английский
Drug Treatment Direction Based on the Molecular Mechanism of Breast Cancer Brain Metastasis
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 262 - 262
Опубликована: Фев. 16, 2025
Today,
breast
cancer
(BC)
is
the
most
frequently
diagnosed
malignancy
and
a
leading
cause
of
cancer-related
deaths
among
women
worldwide.
Brain
metastases
(BMs)
are
common
complication
individuals
with
advanced
cancer,
significantly
impacting
both
survival
rates
overall
condition
life
patients.
This
review
systematically
analyzes
innovative
approaches
to
drug
treatment
for
brain
(BCBMs),
particular
emphasis
placed
on
treatments
targeting
molecular
mechanisms
signaling
pathways
delivery
strategies
blood
barrier
(BBB).
The
article
discusses
various
drugs
that
have
demonstrated
effectiveness
against
BCBM,
featuring
mix
monoclonal
antibodies,
nimble
small-molecule
tyrosine
kinase
inhibitors
(TKIs),
antibody-drug
conjugates
(ADCs).
study
techniques
designed
boost
permeability
BBB
sheds
light
how
these
innovations
can
improve
metastases.
highlights
need
develop
new
therapies
BCBM
optimize
existing
strategies.
With
deeper
comprehension
intricate
advances
in
technology,
it
expected
more
effective
personalized
options
will
become
available
future
patients
BCBM.
Язык: Английский
Transcytosis of LDL Across Arterial Endothelium: Mechanisms and Therapeutic Targets
Arteriosclerosis Thrombosis and Vascular Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Transport
of
LDL
(low-density
lipoprotein)
from
plasma
to
arterial
intima
is
thought
be
rate
limiting
in
the
development
atherosclerosis.
Its
variation
likely
determines
where
lesions
develop
within
arteries
and
might
account
for
some
currently
unexplained
difference
disease
susceptibility
between
individuals.
It
may
also
critical
lipid-rich,
unstable
plaques.
Mechanisms
have
been
controversial
but
recent
evidence
suggests
that
caveolar
transcytosis
across
endothelial
cells
dominant
pathway.
Receptors
involved
are
LDLR
(LDL
receptor),
SR-B1
(scavenger
receptor
class
B
type
1),
ALK1
(activin
receptor-like
kinase
1).
The
role
influenced
by
IL-1β
(interleukin-1β);
HDL
(high-density
lipoprotein),
DOCK4
(dedicator
cytokinesis
4),
GPER
(G-protein–coupled
estrogen
HMGB1
(high
mobility
group
box
1);
BMP
(bone
morphogenetic
protein)
9.
Additionally,
BMP4
stimulates
transcytosis,
FSTL1
(follistatin-like
1
inhibits
it.
Fundamental
transcytotic
mechanisms
include
caveola
formation,
undocking,
trafficking,
docking;
they
cholesterol-lowering
agents,
MYDGF
(myeloid-derived
growth
factor),
MFSD2a
(major
facilitator
superfamily
domain
containing
2a;
blood-brain
barrier),
inhibitors
dynamin-2
tubulin
polymerization.
relative
merits
different
therapeutic
approaches
discussed,
with
statins,
colchicine,
benzimidazoles,
metformin
being
existing
drugs
repurposed
salidroside
glycyrrhizic
acid
nutraceuticals
worth
investigating.
Finally,
we
discuss
against
ferry-boat
model
contributions
receptor-mediated,
fluid-phase,
active
inhibition
most
beneficial.
Язык: Английский
Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 25, 2024
Scutellaria
baicalensis
has
been
used
for
the
treatment
of
digestive
system
disorders
thousands
years
in
China
and
other
regions.
Modern
research
have
revealed
its
therapeutic
efforts
tumors.
Thus,
to
review
updated
progress
S.
main
flavonoids
tumors
past
10
years,
this
article
summarized
effect
molecular
mechanisms
5
on
oral
cavity,
esophagus,
stomach,
colon,
liver,
pancreas
by
inhibiting
tumor
cell
proliferation,
inducing
autophagy,
stimulating
immune
response,
increasing
drug
sensitivity.
In
conclusion,
could
be
applied
treat
with
different
type
methods.
Язык: Английский
Metastatic brain tumors: from development to cutting‐edge treatment
MedComm,
Год журнала:
2024,
Номер
6(1)
Опубликована: Дек. 20, 2024
Abstract
Metastatic
brain
tumors,
also
called
metastasis
(BM),
represent
a
challenging
complication
of
advanced
tumors.
Tumors
that
commonly
metastasize
to
the
include
lung
cancer
and
breast
cancer.
In
recent
years,
prognosis
for
BM
patients
has
improved,
significant
advancements
have
been
made
in
both
clinical
preclinical
research.
This
review
focuses
on
originating
from
We
briefly
overview
history
epidemiology
BM,
as
well
current
diagnostic
treatment
paradigms.
Additionally,
we
summarize
multiomics
evidence
mechanisms
tumor
occurrence
development
era
artificial
intelligence
discuss
role
microenvironment.
Preclinically,
introduce
establishment
models,
detailed
molecular
mechanisms,
cutting‐edge
methods.
is
primarily
treated
with
comprehensive
approach,
including
local
treatments
such
surgery
radiotherapy.
For
cancer,
targeted
therapy
immunotherapy
shown
efficacy,
while
monoclonal
antibodies,
tyrosine
kinase
inhibitors,
antibody–drug
conjugates
are
effective
BM.
Multiomics
approaches
assist
diagnosis
treatment,
revealing
complex
Moreover,
agents
often
need
cross
blood–brain
barrier
achieve
high
intracranial
concentrations,
small‐molecule
nanoparticles,
peptide
drugs.
Addressing
imperative.
Язык: Английский
Biomimetic membrane-coated nanoparticles specially permeate the inflammatory blood-brain barrier to deliver plasmin therapy for brain metastases
Journal of Controlled Release,
Год журнала:
2024,
Номер
378, С. 763 - 775
Опубликована: Дек. 29, 2024
Язык: Английский
Wnt-Regulated Therapeutics for Blood-Brain Barrier Modulation and Cancer Therapy
Bioconjugate Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
The
Wnt
signaling
pathway
has
a
significant
regulatory
part
in
tissue
development
and
homeostasis.
Dysregulation
of
the
been
associated
with
many
diseases
including
cancers
various
brain
diseases,
making
this
promising
therapeutic
target
for
these
diseases.
In
review,
we
describe
roles
blood-brain
barrier
(BBB)
intracranial
tumors
peripheral
tumors,
from
preclinical
clinical
perspectives,
introduce
Wnt-regulated
therapeutics
types
drugs
nanomedicines
as
BBB
modulators
brain-oriented
drug
delivery
cancer
treatments,
finally
discuss
limitations
future
perspectives
therapeutics.
Язык: Английский