Wnt-Regulated Therapeutics for Blood-Brain Barrier Modulation and Cancer Therapy DOI
Pei An, Yang Tong, Rui Mu

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The Wnt signaling pathway has a significant regulatory part in tissue development and homeostasis. Dysregulation of the been associated with many diseases including cancers various brain diseases, making this promising therapeutic target for these diseases. In review, we describe roles blood-brain barrier (BBB) intracranial tumors peripheral tumors, from preclinical clinical perspectives, introduce Wnt-regulated therapeutics types drugs nanomedicines as BBB modulators brain-oriented drug delivery cancer treatments, finally discuss limitations future perspectives therapeutics.

Language: Английский

Brain-tumor-seeking and serpin-inhibiting outer membrane vesicles restore plasmin-mediated attacks against brain metastases DOI

Mengyuan Zhou,

Yuanyuan Lin, Haiyan Chen

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 116 - 126

Published: Sept. 6, 2024

Language: Английский

Citations

4
Drug Treatment Direction Based on the Molecular Mechanism of Breast Cancer Brain Metastasis DOI Creative Commons
Yumin Zhang,

Haotian Shang,

Jiaxuan Zhang

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 262 - 262

Published: Feb. 16, 2025

Today, breast cancer (BC) is the most frequently diagnosed malignancy and a leading cause of cancer-related deaths among women worldwide. Brain metastases (BMs) are common complication individuals with advanced cancer, significantly impacting both survival rates overall condition life patients. This review systematically analyzes innovative approaches to drug treatment for brain (BCBMs), particular emphasis placed on treatments targeting molecular mechanisms signaling pathways delivery strategies blood barrier (BBB). The article discusses various drugs that have demonstrated effectiveness against BCBM, featuring mix monoclonal antibodies, nimble small-molecule tyrosine kinase inhibitors (TKIs), antibody-drug conjugates (ADCs). study techniques designed boost permeability BBB sheds light how these innovations can improve metastases. highlights need develop new therapies BCBM optimize existing strategies. With deeper comprehension intricate advances in technology, it expected more effective personalized options will become available future patients BCBM.

Language: Английский

Citations

0
GRP94 mediates blood-brain barrier permeation and substantia nigra-specific drug distribution in Parkinson’s disease DOI

Ziyan Lv,

Yuteng Zeng,

Tangfeng Lv

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114585 - 114585

Published: Feb. 1, 2025

Language: Английский

Citations

0
Transcytosis of LDL Across Arterial Endothelium: Mechanisms and Therapeutic Targets DOI
Israel O. Bolanle,

Gaetan C. de Liedekerke Beaufort,

Peter D. Weinberg

et al.

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Transport of LDL (low-density lipoprotein) from plasma to arterial intima is thought be rate limiting in the development atherosclerosis. Its variation likely determines where lesions develop within arteries and might account for some currently unexplained difference disease susceptibility between individuals. It may also critical lipid-rich, unstable plaques. Mechanisms have been controversial but recent evidence suggests that caveolar transcytosis across endothelial cells dominant pathway. Receptors involved are LDLR (LDL receptor), SR-B1 (scavenger receptor class B type 1), ALK1 (activin receptor-like kinase 1). The role influenced by IL-1β (interleukin-1β); HDL (high-density lipoprotein), DOCK4 (dedicator cytokinesis 4), GPER (G-protein–coupled estrogen HMGB1 (high mobility group box 1); BMP (bone morphogenetic protein) 9. Additionally, BMP4 stimulates transcytosis, FSTL1 (follistatin-like 1 inhibits it. Fundamental transcytotic mechanisms include caveola formation, undocking, trafficking, docking; they cholesterol-lowering agents, MYDGF (myeloid-derived growth factor), MFSD2a (major facilitator superfamily domain containing 2a; blood-brain barrier), inhibitors dynamin-2 tubulin polymerization. relative merits different therapeutic approaches discussed, with statins, colchicine, benzimidazoles, metformin being existing drugs repurposed salidroside glycyrrhizic acid nutraceuticals worth investigating. Finally, we discuss against ferry-boat model contributions receptor-mediated, fluid-phase, active inhibition most beneficial.

Language: Английский

Citations

0
Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors DOI Creative Commons
Kangning Zhao, Jinlong Zhang, Lin Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Scutellaria baicalensis has been used for the treatment of digestive system disorders thousands years in China and other regions. Modern research have revealed its therapeutic efforts tumors. Thus, to review updated progress S. main flavonoids tumors past 10 years, this article summarized effect molecular mechanisms 5 on oral cavity, esophagus, stomach, colon, liver, pancreas by inhibiting tumor cell proliferation, inducing autophagy, stimulating immune response, increasing drug sensitivity. In conclusion, could be applied treat with different type methods.

Language: Английский

Citations

1
Metastatic brain tumors: from development to cutting‐edge treatment DOI Creative Commons
Guilong Tanzhu,

Liu Chen,

Jiaoyang Ning

et al.

MedComm, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 20, 2024

Abstract Metastatic brain tumors, also called metastasis (BM), represent a challenging complication of advanced tumors. Tumors that commonly metastasize to the include lung cancer and breast cancer. In recent years, prognosis for BM patients has improved, significant advancements have been made in both clinical preclinical research. This review focuses on originating from We briefly overview history epidemiology BM, as well current diagnostic treatment paradigms. Additionally, we summarize multiomics evidence mechanisms tumor occurrence development era artificial intelligence discuss role microenvironment. Preclinically, introduce establishment models, detailed molecular mechanisms, cutting‐edge methods. is primarily treated with comprehensive approach, including local treatments such surgery radiotherapy. For cancer, targeted therapy immunotherapy shown efficacy, while monoclonal antibodies, tyrosine kinase inhibitors, antibody–drug conjugates are effective BM. Multiomics approaches assist diagnosis treatment, revealing complex Moreover, agents often need cross blood–brain barrier achieve high intracranial concentrations, small‐molecule nanoparticles, peptide drugs. Addressing imperative.

Language: Английский

Citations

1
Biomimetic membrane-coated nanoparticles specially permeate the inflammatory blood-brain barrier to deliver plasmin therapy for brain metastases DOI

Mei Zhao,

Yuanyuan Lin,

Yuteng Zeng

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 763 - 775

Published: Dec. 29, 2024

Language: Английский

Citations

1
Wnt-Regulated Therapeutics for Blood-Brain Barrier Modulation and Cancer Therapy DOI
Pei An, Yang Tong, Rui Mu

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The Wnt signaling pathway has a significant regulatory part in tissue development and homeostasis. Dysregulation of the been associated with many diseases including cancers various brain diseases, making this promising therapeutic target for these diseases. In review, we describe roles blood-brain barrier (BBB) intracranial tumors peripheral tumors, from preclinical clinical perspectives, introduce Wnt-regulated therapeutics types drugs nanomedicines as BBB modulators brain-oriented drug delivery cancer treatments, finally discuss limitations future perspectives therapeutics.

Language: Английский

Citations

0