A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12091 - 12091

Опубликована: Ноя. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Язык: Английский

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Nanoconjugate Carrying pH-Responsive Transferrin Receptor-Targeted Hesperetin Triggers Triple-Negative Breast Cancer Cell Death through Oxidative Attack and Assemblage of Pro-Apoptotic Proteins

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(11), С. 7556 - 7573

Опубликована: Ноя. 6, 2024

Triple-negative breast cancer (TNBC) is recognized as a major aggressive subtype of due to its expeditious worsening growth, extensive metastatic capability, and recalcitrance standard current treatments. Hesperetin (HSP), natural bioflavonoid from citrus fruits, demonstrates pronounced anticancer efficacy, but hydrophobicity limits clinical development. The present study reports the fabrication biocompatible pH-responsive transferrin (TF) receptor-targeted HSP-loaded poly(lactic-co-glycolic acid) (PLGA) nanobioconjugate (PLGA-HSP-TF NPs) exploration in vitro vivo antineoplastic potential. PLGA nanoparticles (NPs), PLGA-HSP NPs, PLGA-HSP-TF NPs were synthesized characterized by DLS, FTIR, FE-SEM, 1H NMR spectroscopy. stability release profile inspected, efficacy was scrutinized terms cytotoxicity, oxidative stress apoptosis biomarkers, cell cycle arrest. In tumor regression host survival studies executed Ehrlich ascites carcinoma (EAC) cell-bearing Swiss albino mice. drug uptake highly stable accomplished effectively MDA-MB-231 cells showed pH-dependent intracellular HSP, which generated excessive reactive oxygen species (ROS) that led assault TNBC cells. This elevated ROS dropped mitochondrial membrane potential triggered apoptosis-mediated death arresting at G0/G1 phase. Furthermore, unveiled significant compared free HSP with minimum toxicity dose 20 mg/kg body weight. divulges may be an astounding nanocandidate for triple-negative therapy.

Язык: Английский

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Green Synthesis of Selenium Nanoparticles: Characterization and Therapeutic Applications in Microbial and Cancer Treatments

International Research Journal of Multidisciplinary Technovation, Год журнала: 2024, Номер unknown, С. 11 - 25

Опубликована: Апрель 15, 2024

Selenium is one of these micronutrients that are essential for animals, plants and microorganisms to remain functional. This review about the green synthesis selenium nanoparticles its application in microbial cancer therapies. Our hypothesis was Se NPs produced using plant extracts might offer biocompatibility environmental friendliness advantages, hence be a new prospect medical applications. To test our hypothesis, we conducted comprehensive analysis recent literature, exploring various conditions processes NPs. Various characterisation techniques such as spectroscopy, microscopy physicochemistry were discussed order provide insight into formation function green-synthesised findings show by chemistry methods have good properties uniform size, shape stability detailed examples from studies reveal. Furthermore, therapeutic theranostic applications this manner: their potential antimicrobial anticancer treatments. Through illustrations cases where inhibit growth cause apoptosis cells, practical significance underscored. In summary, affirms green-mediated improves efficacy, thus opening up realms research.

Язык: Английский

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Innovative Nanoformulation Strategies of Hesperetin and Hesperidin: Pioneering Advances in Pharmaceutical Applications (A Review)

Russian Journal of Bioorganic Chemistry, Год журнала: 2024, Номер 50(6), С. 2397 - 2425

Опубликована: Дек. 1, 2024

Язык: Английский

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