Mediterranean Journal of Nutrition and Metabolism, Год журнала: 2024, Номер 17(3), С. 255 - 259
Опубликована: Авг. 27, 2024
Язык: Английский
Biogerontology, Год журнала: 2023, Номер 24(5), С. 609 - 662
Опубликована: Июль 30, 2023
Язык: Английский
Процитировано
75
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(24), С. 15743 - 15743
Опубликована: Дек. 12, 2022
Diabetes is considered a new pandemic of the modern world, and number sufferers steadily increasing. Sustained hyperglycemia promotes production free radicals leads to persistent, low-grade inflammation. Oxidative stress causes mitochondrial destruction, which along with activation hexosamine pathway, nuclear factor-κB (Nf-κb), p38 mitogen-activated protein kinase (p38 MAPK), c-jun NH2 terminal kinase/stress-activated (JNK/SAPK) or toll-like receptors (TLRs), pancreatic β-cell dysfunction. However, there also protective mechanism that counteracts oxidative inflammation in diabetes, mitophagy, autophagy. An important part strategy control diabetes lead healthy lifestyle based on, among other things, regular physical activity, giving up smoking, eating balanced diet containing ingredients antioxidant potential, including vegetables fruits, using hypoglycemic pharmacotherapy. Tobacco smoke recognized modifiable risk factor for many diseases it has been shown disease increases proportion intensity smoking. Physical activity as another component therapy can effectively reduce glucose fluctuations, high interval exercise appears have most beneficial effect. A proper not only cellular sensitivity insulin, but able stress. Pharmacotherapy affect Some oral drugs, such metformin, pioglitazone, vildagliptin, liraglutide, exenatide, cause reduction markers and/or inflammation, while drug Imeglimin reverses In studies sitagliptin, vildagliptin effects on were achieved by, reducing glycemic excursions. For insulin therapy, no corresponding correlation was observed. Insulin did parameters. There between variability patients therapy. The data used this study obtained by searching PubMed online databases, taking into account recent studies.
Язык: Английский
Процитировано
71
Neurochemistry International, Год журнала: 2023, Номер 164, С. 105490 - 105490
Опубликована: Янв. 24, 2023
Язык: Английский
Процитировано
59
All Life, Год журнала: 2024, Номер 17(1)
Опубликована: Фев. 21, 2024
'Oxidative stress' (OS) refers to the deviations in redox biology inside biological systems. This term has been used illustrate imbalance between oxidants and antioxidants, which a subject of extensive research. The obtained findings suggest that many diseases are linked OS, including diabetes mellitusinflammation, cancers, autoimmune disorders neurodegenerative diseases. More recently, significant advances biochemistry molecular have enabled researchers find master switches various OS mechanisms associate development paradigms. In this review, brief overview research is provided offer insight into its future directions. Most importantly, need for greater understanding vital role progression emphasized. Likewise, more work needed on utility reactive oxygen species markers as diagnostic tool.
Язык: Английский
Процитировано
10
Molecules, Год журнала: 2022, Номер 27(16), С. 5232 - 5232
Опубликована: Авг. 16, 2022
Background: Several clinical trials have suggested that resveratrol has hypoglycemic properties; however, there are other studies in which such an effect not been observed. Methods: We carried out a systematic search several databases; seventeen were selected for the review and fifteen included meta-analysis. Results: Resveratrol decreases glucose levels subjects aged 45–59 years at doses <250 mg/day (−8.64 mg/dL, p < 0.00001), 250–500 (−22.24 = 0.0003), 500–1000 (−28.40 0.0008), while older than 60 years, it only with of mg/day. Likewise, HbA1c improved mg (−0.60%, but years. Insulin 250 (−0.80 mIU/L, 0.0003) (−5.0 although they (−1.79 0.01). On hand, HOMA-IR (−0.40, Conclusions: statistically significant dose–response on concentrations, HbA1c, insulin levels; is enough scientific evidence to propose therapeutic dose.
Язык: Английский
Процитировано
25
Journal of Internal Medicine, Год журнала: 2022, Номер 293(2), С. 166 - 183
Опубликована: Окт. 22, 2022
Abstract Experimental trials in organisms ranging from yeast to humans have shown that various forms of reducing food intake (caloric restriction) appear increase both overall and healthy lifespan, delaying the onset disease slowing progression biomarkers aging. The gut microbiota is considered one key environmental factors strongly contributing regulation host health. Perturbations composition activity microbiome are thought be involved emergence multiple diseases. Indeed, many studies investigating been performed strong associations between specific microorganisms metabolic diseases including overweight, obesity, type 2 diabetes mellitus as well gastrointestinal disorders, neurodegenerative diseases, even cancer. Dietary interventions known reduce inflammation improve health potentiated by prior fasting. Inversely, birth weight differential oxidative phosphorylation response fasting implies epigenetic control some its effector pathways. There substantial evidence for efficacy improving insulin signaling blood glucose control, inflammation, conditions which, additionally, has identified a site risk protective factors. Accordingly, human microbiota, symbiont pathobiont roles, proposed impact mediate benefits could potentially affect these While results small‐N diverge, consistently enriches widely recognized anti‐inflammatory commensals such Faecalibacterium other short‐chain fatty acid producers, which likely mediates effects through immune system barrier function impact.
Язык: Английский
Процитировано
24
Frontiers in Cardiovascular Medicine, Год журнала: 2022, Номер 9
Опубликована: Июнь 1, 2022
Vascular smooth muscle cells (VSMCs) are the primary cell type involved in atherosclerosis process; senescent VSMCs observed both aged vessels and atherosclerotic plaques. Factors associated with process, including oxidative stress, inflammation, calcium-regulating factors, closely linked to senescence VSMCs. A number of experimental studies using traditional cellular aging markers have suggested that anti-aging biochemical agents could be used treat atherosclerosis. However, doubt has recently been cast on such potential due increasingly apparent complexity status an incomplete understanding role these play as well a lack specific or spectrum-limited markers. The utility drugs treatment should reevaluated. Promotion healthy lifestyle, exploring depth characteristics each atherosclerosis, VSMCs, development targeted drug delivery systems will ensure efficacy whilst evaluation safety tolerability use key aims future anti-atherosclerosis research. This review summarizes VSMC during factors regulating this overview progress toward application drugs.
Язык: Английский
Процитировано
23
Molecules, Год журнала: 2023, Номер 28(17), С. 6203 - 6203
Опубликована: Авг. 23, 2023
Free radicals and oxidants may cause various damages both to the lifeworld different products. A typical solution for prophylaxis of oxidation-caused conditions is usage antioxidants. Among them, classes are found-polyphenols, conjugated polyalkenes, some sulfur nitrogen derivatives. Regarding active site in molecules, a widely discussed group compounds 1,3-dicarbonyl compounds. them natural (e.g., curcumin pulvinic acids) synthetic 4-hydroxy coumarins, substituted Meldrum's Herein, information about containing moiety covered, their antiradical antioxidant activity, depending on structure, discussed.
Язык: Английский
Процитировано
14
Free Radical Biology and Medicine, Год журнала: 2024, Номер 217, С. 179 - 189
Опубликована: Март 14, 2024
Redox organization governs an underlying simplicity in living systems. Critically, redox reactions enable the essential characteristics of life: extraction energy from environment, use to support metabolic and structural organization, dynamic responses defend against environmental threats, mechanisms direct differentiation cells organ systems for reproduction. These processes are sustained through a context which electron donor/acceptor couples poised at substantially different steady-state potentials, some with relatively reducing steady states others oxidizing states. Redox-sensitive thiols proteome, as well low molecular weight redox-active molecules, maintained individually by kinetics oxidation-reduction within this system. Recent research has revealed opposing network interactions metallome, metabolome transcriptome, appear be evolved response structure maintain stability organism presence variable oxidative environments. Considerable opportunity exists improve human health detailed understanding these networks so that targeted interventions can developed new avenues medicine.
Язык: Английский
Процитировано
5
Cells, Год журнала: 2023, Номер 12(13), С. 1679 - 1679
Опубликована: Июнь 21, 2023
Chronic kidney disease (CKD) is a serious health problem that can affect various systems in the human body. Renal failure promotes mechanisms of premature cellular aging and also features generalized inflammation body, which translates into close relationship between dysfunction cardiovascular (CVD). As function deteriorates, risk mortality increase this group patients. Oxidative stress are two closely related processes initiate vicious cycle by activating each other. Together with aging, they represent key factors cause exacerbate CVD CKD. Patients CKD particularly vulnerable to accumulation endothelial cells, vascular smooth muscle macrophages, increasing atherosclerosis. Several known lead progression aforementioned problems, such as uremic toxins, persistent inflammation, impaired lipid electrolyte metabolism, nitric oxide (NO) deficiency, increased production reactive oxygen species (ROS) damage deoxyribonucleic acid (DNA) mitochondria. According research, we distinguish drugs effectively counteract negative effects CKD—statins. This inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase number pathways, resulting overall slowing atherosclerosis aging.
Язык: Английский
Процитировано
11