Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis

Phytomedicine, Год журнала: 2024, Номер 128, С. 155258 - 155258

Опубликована: Янв. 11, 2024

Язык: Английский

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Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions

MedComm, Год журнала: 2024, Номер 5(4)

Опубликована: Апрель 1, 2024

Abstract At present, diabetes mellitus (DM) has been one of the most endangering healthy diseases. Current therapies contain controlling high blood sugar, reducing risk factors like obesity, hypertension, and so on; however, DM patients inevitably eventually progress into different types complications, resulting in poor quality life. Unfortunately, clear etiology pathogenesis complications have not elucidated owing to intricate whole‐body systems. The immune system was responsible regulate homeostasis by triggering or resolving inflammatory response, indicating it may be necessary complications. In fact, previous studies shown inflammation plays multifunctional roles is attracting attention meaningful therapeutic strategy. To this end, review systematically concluded current over relationships susceptible (e.g., diabetic cardiomyopathy, retinopathy, peripheral neuropathy, nephropathy) inflammation, ranging from cell cytokines interaction pathomechanism organ injury. Besides, we also summarized various strategies improve target special remedies conventional lifestyle changes. This will offer a panoramic insight mechanisms an perspective discuss contemporary clinical interventions.

Язык: Английский

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Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents

Journal of Basic and Clinical Physiology and Pharmacology, Год журнала: 2023, Номер 34(2), С. 235 - 242

Опубликована: Фев. 18, 2023

Abstract Objectives Regular treadmill exercise may result in changes pro-inflammatory cytokines and oxidative stress. However, the way acute mechanisms affect stress obese has not been comprehensively exposed. This study aimed to analyze between 30 min before 24 h after adolescents. Methods A total of 20 females aged 19–24 years were recruited from female students given one session with an intensity 60–70% HR max . Thiobarbituric acid reactive substance (TBARS) was used serum levels MDA, while enzyme-linked immunosorbent assay (ELISA) TNF-α IL-6. Moreover, independent samples t-test a significance level 5% employed have statistical analysis. Results The results on delta (Δ) CTRL TREG showed significant difference (p<0.001). Conclusions found decrease Therefore, can be promising strategy for preventing adolescents obesity as well disease risks associated chronic inflammation.

Язык: Английский

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Biomarkers of Oxidative Stress in Diabetes Mellitus with Diabetic Nephropathy Complications

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13541 - 13541

Опубликована: Авг. 31, 2023

The present study aimed to investigate and compare biomarkers of oxidative stress the activity antioxidant enzymes in plasma patients with different stages diabetic nephropathy. For this purpose, we studied (1) levels reactive oxygen species nitrogen as parameters, (2) lipid protein oxidation, (3) enzymes, (4) cytokine production. Patients type 2 diabetes mellitus were divided into three groups according loss renal function: compensated normal function DMT2N0 measured an estimated glomerular filtration rate (eGFR) ≥ 90 mL/min/1.73 m2, a group decompensated complication nephropathy mild-to-moderate DMT2N1 (eGFR < 60 m2: 59-45 m2), moderate-to-severe DMT2N2 > 30 30-44 m2). All results compared healthy volunteers. showed that had significantly higher ROS, production, end products oxidation Furthermore, depleted nitric oxide (NO), impaired NO synthase (NOS) system, reduced enzyme (p 0.05). These findings suggest are unable compensate for stress. decreased radicals advanced complications may be attributed damage availability plasma. highlights compromised status contributing factor mellitus. have implications understanding pathogenesis role chronic inflammation its development. assessment inflammatory aid early detection prediction complications.

Язык: Английский

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Research progress of the effective active ingredients of Astragalus mongholicus in the treatment of diabetic peripheral neuropathy

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 173, С. 116350 - 116350

Опубликована: Март 1, 2024

Diabetic peripheral neuropathy (DPN) is one of the most prevalent consequences diabetes, with a high incidence and disability rate. The DPN's pathogenesis extremely complex yet to be fully understood. Persistent glucose metabolism, nerve growth factor deficiency, microvascular disease, oxidative stress, cell apoptosis, immune factors, other factors have been implicated in DPN. Astragalus mongholicus commonly used plant treat DPN clinical settings. Its rich chemical components mainly include polysaccharide, saponins, flavones, etc., which play vital role treatment This review aimed summarize studies on mechanism effective treating great significance for use Chinese herbal medicine promotion its status influence world.

Язык: Английский

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Anti-Inflammatory and α-Glucosidase Inhibitory Triterpenoid with Diverse Carbon Skeletons from the Fruits of Rosa roxburghii

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(20), С. 11503 - 11514

Опубликована: Апрель 18, 2024

The fruits of Rosa roxburghii Tratt. are edible nutritional food with high medicinal value and have been traditionally used as Chinese folk medicine for a long time. In this study, 26 triterpenoids including four new pentacyclic triterpenoids, roxbuterpenes A–D (1, 4, 5, 24), along 22 known analogues (2, 3, 6–23, 25, 26), were isolated from the R. roxburghii. Their chemical structures determined on basis extensive spectroscopic analyses (including IR, HRESIMS NMR spectroscopy). absolute configuration roxbuterpene A (1) was by an X-ray crystallographic analysis. This is first report crystal structure 5/6/6/6/6-fused system triterpenoid. Notably, B (1 4) possessed A-ring contracted triterpenoid nortriterpenoid skeletons rare system, respectively. Compounds 1–7, 11, 13–15, 18–20, 24, 25 exhibited moderate or potent inhibitory activities against α-glucosidase. 2, 6, 14 showed strong α-glucosidase IC50 values 8.4 ± 1.6, 7.3 2.2, 13.6 1.4, 0.9 0.4, 12.5 2.4 μM, respectively (positive control acarbose, 10.1 0.8 μM). 13, 14, 16 moderately inhibited release NO (nitric oxide) ranging 25.1 2.0 to 51.4 3.1 μM. Furthermore, expressions TNF-α (tumor necrosis factor-α) IL-6 (interleukin-6) detected ELISA (enzyme-linked immunosorbent assay), compounds effects in dose-dependent manner 50

Язык: Английский

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Assessment of in silico antioxidant, anti-inflammatory, and antidiabetic activites of ximenia Americana L. Olacaceae

Advances in Medical Pharmaceutical and Dental Research, Год журнала: 2024, Номер 4(1), С. 1 - 1

Опубликована: Март 15, 2024

Persistent hyperglycemia leading to oxidative stress and inflammatory response contributes the pathology of diabetes. This study investigated antioxidant, anti-inflammatory, antidiabetic potential Ximenia americana (XA) L. Olacaceae in silico exploring its possible mechanism action. The was carried out by molecular docking compounds present XA with targets followed dynamics simulation. Stigmasterol exhibited lowest respective binding affinity inhibition constant xanthine oxidases (-8.7 kcal/mol 4.13 ×10 -1 µM), cytochrome p450 21A2 (-11.5 3.64 × 10 -3 myeloperoxidase (-10 4.59 -2 phospholipase A2 (-9.3 1.50 inducible nitric oxide synthase (-10.8 1.19 11β hydroxy-steroid dehydrogenase 1 (-9.4 1.27×10 alpha-amylase (-9.6 µM) while 4,4-Dimethylcyclohex-2-en-1-ol showed least BA (-7.6 kcal/mol) Ki (2.65 interleukin associated kinase 4. Furthermore, simulation shows high residue displacements up 6.11, 3.69, 4.97, 5.24, 4.21, 4.41, 5.80, 5.76 Å for oxidase, 21A2, myeloperoxidase, A2, synthase, 4, alpha-amylase, 1, respectively. Conclusively, stigmasterol might be key involved activity via enzymes stress, inflammation, Received: 13 October 2023 Accepted: 20 February 2024 Published: 15 March

Язык: Английский

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Apitherapy for diabetes mellitus: mechanisms and clinical implications

Journal of Complementary and Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Diabetes mellitus is a complex disease in terms of its causes and pathophysiological processes, it produces significant impact on health leads to complications that are difficult manage.

Язык: Английский

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Lactate Mediates Exercise-Induced Modulation of Mitophagy and Ferroptosis, Reducing Amyloid-Beta and Tau in Type 2 Diabetes: A Molecular Study

Опубликована: Янв. 1, 2025

Background: This study examined the impact of lactate accumulation, induced by high-intensity interval training (HIIT), on reducing amyloid-beta (Aβ) and tau protein levels through enhanced mitophagy decreased ferroptosis in hippocampus type 2 diabetic rats.Methods: Thirty-two male Wistar rats were divided into four groups: control (Co), exercise (EX), diabetes (DB), with (DB + EX). Diabetes was DB EX groups via a high-fat diet followed streptozotocin injection (35 mg/kg). The performed treadmill-based HIIT, involving 4–10 running intervals at 80–100% Vmax. Serum hippocampal expression MCT2, SIRT1, BDNF, p62, Keap1, NRF2, MDA, GPX4, PINK1, parkin, Aβ, Tau assessed.Results: In group, Parkin elevated, while reduced compared to group.Conclusion: HIIT enhances reduces lactate-SIRT1-BDNF p62-Keap1-NRF2 pathways, potentially mitigating Aβ accumulation.

Язык: Английский

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The Interactive Effects of Fruit Intake Frequency and Serum miR-484 Levels as Biomarkers for Incident Type 2 Diabetes in a Prospective Cohort of the Spanish Adult Population: The [email protected] Study

Biomedicines, Год журнала: 2025, Номер 13(1), С. 160 - 160

Опубликована: Янв. 10, 2025

Background/Objectives: Although evidence suggests that miR-484 and several fruit components are involved in glucose metabolism insulin resistance metabolic pathways, the relationship between serum levels consumption relation to risk of Type 2 diabetes (T2DM) remains elusive. The aim this study was evaluate possible association intake frequency with T2DM Spanish adult population. Methods: 2234 subjects from [email protected] cohort without at baseline were studied. Socio-demographic, anthropometric clinical data recorded, as well responses a questionnaire on habits, including (daily vs. occasional). diagnosed after 7.5 years follow-up. Baseline measured using real-time qPCR categorized based 25th percentile. Association analyses performed logistic regression models adjusted for potential confounders. Interaction effects evaluated multiplicative additive scales. Results: There no frequency. Categorized inversely independently associated likelihood incident T2DM. Analysis interaction effect presence both positive interactions categories Conclusions: Our demonstrates protective daily high regarding supports nutritional recommendations advocating consumption. This also combined low occasional may increase beyond their independent effects.

Язык: Английский

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