Porous Gelatin Methacrylate Gel Engineered by Freeze-Ultraviolet Promotes Osteogenesis and Angiogenesis DOI
Haoran Wang, Jianfeng Li,

Ran Qin

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(9), С. 5764 - 5773

Опубликована: Авг. 27, 2024

Alveolar bone defect reconstruction is a common challenge in stomatology. To address this, thermosensitive/photosensitive gelatin methacrylate (GelMA) gel was developed based on various air solubilities and light-curing technologies. The synthesized by using freeze-ultraviolet (FUV) method to form porous quickly (within 15 min) solidifying modified network structure. Unlike other scaffolds limited complex preparation procedures residual products, this FUV-GelMA shows favorable manufacturing ability, promising biocompatibility, adjustable macroporous structures. results from rat model suggested that scaffold creates conducive microenvironment for mandible vascularization. In vitro experiments further confirmed the promotes osteogenic differentiation of human marrow mesenchymal stem cells angiogenesis umbilical vein endothelial cells. Investigation underlying mechanism focused p38 mitogen-activated protein kinase (MAPK) pathway. We found SB203580, specific inhibitor MAPK, abolished therapeutic effects osteogenesis angiogenesis, both vivo. These findings introduced novel approach scaffold-based tissue regeneration future clinical applications.

Язык: Английский

Highly biologically functional magnesium silicate-coated 3D printed round pore-shaped titanium scaffold alters exosomal miRNA expression to promote osteogenic differentiation for bone defect repair DOI

Xuwei Luo,

Zhencheng Xiong, Dong Wang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 489, С. 151372 - 151372

Опубликована: Апрель 17, 2024

Язык: Английский

Процитировано

6
An Injectable Black Phosphorus Hydrogel for Rapid Tooth Extraction Socket Healing DOI

Fanyi Guo,

Jianfeng Li, Ziyu Chen

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(20), С. 25799 - 25812

Опубликована: Май 10, 2024

The excess production of reactive oxygen species (ROS) will delay tooth extraction socket (TES) healing. In this study, we developed an injectable thermosensitive hydrogel (NBP@BP@CS) used to treat TES formulation incorporated black phosphorus (BP) nanoflakes, recognized for their accelerated alveolar bone regeneration and ROS-scavenging properties, dl-3-n-butylphthalide (NBP), a vasodilator aimed at enhancing angiogenesis. vivo investigations strongly demonstrated that NBP@BP@CS improved healing due antioxidation promotion by BP nanoflakes. sustained release NBP from the promoted neovascularization vascular remodeling. Our results designed provided great opportunity not only ROS elimination but also osteogenesis angiogenesis, reflecting "three birds with one stone" concept, has tremendous potential rapid

Язык: Английский

Процитировано

5
Diagnostic significance of LncRNA MIAT in periodontitis and the molecular mechanisms influencing periodontal ligament fibroblasts via the miR-204-5p/DKK1 axis DOI
Yufeng Ren,

Jiwen Zheng,

Chaoyong Yang

и другие.

Archives of Oral Biology, Год журнала: 2024, Номер 168, С. 106066 - 106066

Опубликована: Авг. 4, 2024

Язык: Английский

Процитировано

0
Porous Gelatin Methacrylate Gel Engineered by Freeze-Ultraviolet Promotes Osteogenesis and Angiogenesis DOI
Haoran Wang, Jianfeng Li,

Ran Qin

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(9), С. 5764 - 5773

Опубликована: Авг. 27, 2024

Alveolar bone defect reconstruction is a common challenge in stomatology. To address this, thermosensitive/photosensitive gelatin methacrylate (GelMA) gel was developed based on various air solubilities and light-curing technologies. The synthesized by using freeze-ultraviolet (FUV) method to form porous quickly (within 15 min) solidifying modified network structure. Unlike other scaffolds limited complex preparation procedures residual products, this FUV-GelMA shows favorable manufacturing ability, promising biocompatibility, adjustable macroporous structures. results from rat model suggested that scaffold creates conducive microenvironment for mandible vascularization. In vitro experiments further confirmed the promotes osteogenic differentiation of human marrow mesenchymal stem cells angiogenesis umbilical vein endothelial cells. Investigation underlying mechanism focused p38 mitogen-activated protein kinase (MAPK) pathway. We found SB203580, specific inhibitor MAPK, abolished therapeutic effects osteogenesis angiogenesis, both vivo. These findings introduced novel approach scaffold-based tissue regeneration future clinical applications.

Язык: Английский

Процитировано

0