Porous Gelatin Methacrylate Gel Engineered by Freeze-Ultraviolet Promotes Osteogenesis and Angiogenesis DOI
Haoran Wang, Jianfeng Li,

Ran Qin

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(9), P. 5764 - 5773

Published: Aug. 27, 2024

Alveolar bone defect reconstruction is a common challenge in stomatology. To address this, thermosensitive/photosensitive gelatin methacrylate (GelMA) gel was developed based on various air solubilities and light-curing technologies. The synthesized by using freeze-ultraviolet (FUV) method to form porous quickly (within 15 min) solidifying modified network structure. Unlike other scaffolds limited complex preparation procedures residual products, this FUV-GelMA shows favorable manufacturing ability, promising biocompatibility, adjustable macroporous structures. results from rat model suggested that scaffold creates conducive microenvironment for mandible vascularization. In vitro experiments further confirmed the promotes osteogenic differentiation of human marrow mesenchymal stem cells angiogenesis umbilical vein endothelial cells. Investigation underlying mechanism focused p38 mitogen-activated protein kinase (MAPK) pathway. We found SB203580, specific inhibitor MAPK, abolished therapeutic effects osteogenesis angiogenesis, both vivo. These findings introduced novel approach scaffold-based tissue regeneration future clinical applications.

Language: Английский

Highly biologically functional magnesium silicate-coated 3D printed round pore-shaped titanium scaffold alters exosomal miRNA expression to promote osteogenic differentiation for bone defect repair DOI

Xuwei Luo,

Zhencheng Xiong, Dong Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 489, P. 151372 - 151372

Published: April 17, 2024

Language: Английский

Citations

6
An Injectable Black Phosphorus Hydrogel for Rapid Tooth Extraction Socket Healing DOI

Fanyi Guo,

Jianfeng Li, Ziyu Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(20), P. 25799 - 25812

Published: May 10, 2024

The excess production of reactive oxygen species (ROS) will delay tooth extraction socket (TES) healing. In this study, we developed an injectable thermosensitive hydrogel (NBP@BP@CS) used to treat TES formulation incorporated black phosphorus (BP) nanoflakes, recognized for their accelerated alveolar bone regeneration and ROS-scavenging properties, dl-3-n-butylphthalide (NBP), a vasodilator aimed at enhancing angiogenesis. vivo investigations strongly demonstrated that NBP@BP@CS improved healing due antioxidation promotion by BP nanoflakes. sustained release NBP from the promoted neovascularization vascular remodeling. Our results designed provided great opportunity not only ROS elimination but also osteogenesis angiogenesis, reflecting "three birds with one stone" concept, has tremendous potential rapid

Language: Английский

Citations

5
Diagnostic significance of LncRNA MIAT in periodontitis and the molecular mechanisms influencing periodontal ligament fibroblasts via the miR-204-5p/DKK1 axis DOI
Yufeng Ren,

Jiwen Zheng,

Chaoyong Yang

et al.

Archives of Oral Biology, Journal Year: 2024, Volume and Issue: 168, P. 106066 - 106066

Published: Aug. 4, 2024

Language: Английский

Citations

0
Porous Gelatin Methacrylate Gel Engineered by Freeze-Ultraviolet Promotes Osteogenesis and Angiogenesis DOI
Haoran Wang, Jianfeng Li,

Ran Qin

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(9), P. 5764 - 5773

Published: Aug. 27, 2024

Alveolar bone defect reconstruction is a common challenge in stomatology. To address this, thermosensitive/photosensitive gelatin methacrylate (GelMA) gel was developed based on various air solubilities and light-curing technologies. The synthesized by using freeze-ultraviolet (FUV) method to form porous quickly (within 15 min) solidifying modified network structure. Unlike other scaffolds limited complex preparation procedures residual products, this FUV-GelMA shows favorable manufacturing ability, promising biocompatibility, adjustable macroporous structures. results from rat model suggested that scaffold creates conducive microenvironment for mandible vascularization. In vitro experiments further confirmed the promotes osteogenic differentiation of human marrow mesenchymal stem cells angiogenesis umbilical vein endothelial cells. Investigation underlying mechanism focused p38 mitogen-activated protein kinase (MAPK) pathway. We found SB203580, specific inhibitor MAPK, abolished therapeutic effects osteogenesis angiogenesis, both vivo. These findings introduced novel approach scaffold-based tissue regeneration future clinical applications.

Language: Английский

Citations

0