Low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal Fndc5/irisin signaling DOI Creative Commons
Degang Song, Xiaohong Chen, N. Zhou

и другие.

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Фев. 23, 2023

Abstract Background Exercise-related signaling Fndc5/irisin expresses in brain and acts as a crucial regulator of cognitive function, but its detailed roles vascular dementia (VaD) are still unclear. Low intensity pulsed ultrasound (LIPUS), novel stimulation approach, has been suggested promising treatment for dementia. Here, we investigated the activity efficacy experimental VaD, further explored whether potential effects LIPUS on VaD is related to Fndc5/irisin. Methods Mouse model was established with chronic cerebral hypoperfusion (CCH) using bilateral common carotid arteries stenosis (BCAS). Transcranial applied 24 h after BCAS subsequently daily time 5 min at an pressure 0.51 MPa period 28 days. The levels different regions, hippocampal long-term potentiation anti-inflammatory cytokines were day evaluation. Global Fndc5 knock-out (F5KO), forced expression or knockdown Fndc5, recombinant irisin application respectively employed mechanism exploration. neuron dendritic spine density astrocyte phenotype detected vitro. Results reduced hippocampus mice, intrahippocampal injection improved synaptic plasticity inflammatory microenvironment, then alleviated impairments. existed positive enhancing thus triggering beneficial neuromodulation protection. Importantly, neurorestorative CCH-induced damages totally reversed by WT F5KO mice. Moreover, mediated upregulated well secretion neurons. neuron-secreted drove reactive astrocytes neuroprotective phenotype. Conclusion induced against may be through upregulation levels. Hippocampal might strategic target VaD.

Язык: Английский

Mental health care for older adults: recent advances and new directions in clinical practice and research DOI
Charles F. Reynolds, Dilip V. Jeste, Perminder S. Sachdev

и другие.

World Psychiatry, Год журнала: 2022, Номер 21(3), С. 336 - 363

Опубликована: Сен. 8, 2022

The world's population is aging, bringing about an ever-greater burden of mental disorders in older adults. Given multimorbidities, the health care these people and their family caregivers labor-intensive. At same time, ageism a big problem for people, with without disorders. Positive elements such as resilience, wisdom prosocial behaviors, need to be highlighted promoted, both combat stigma help protect improve positive psychiatry aging not oxymoron, but scientific construct strongly informed by research evidence. We champion broader concept geriatric - one that encompasses well illness. In present paper, we address issues context four are greatest source years lived disability: neurocognitive disorders, major depression, schizophrenia, substance use emphasize implementation multidisciplinary team care, comprehensive assessment, clinical management, intensive outreach, coordination mental, physical social services. also underscore further into moderators mediators treatment response variability. Because optimal adults patient-focused family-centered, call enhancing well-being caregivers. To optimize safety efficacy pharmacotherapy, attention metabolic, cardiovascular neurological tolerability much needed, together development testing medications reduce risk suicide. normal cognitive antidote catalyst change way think per se late-life more specifically. It this provide directions future research.

Язык: Английский

Процитировано

173
Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics DOI Creative Commons
Giulia Grande, Alessandra Marengoni, Davide Liborio Vetrano

и другие.

Alzheimer s & Dementia, Год журнала: 2021, Номер 17(5), С. 768 - 776

Опубликована: Янв. 6, 2021

Abstract Introduction We investigate dementia risk in older adults with different disease patterns and explore the role of inflammation apolipoprotein E ( APOE ) genotype. Methods A total 2,478 dementia‐free participants two or more chronic diseases (ie, multimorbidity) part Swedish National study on Aging Care Kungsholmen (SNAC‐K) were grouped according to their multimorbidity followed detect clinical dementia. The potential modifier effect C‐reactive protein (CRP) genotype was tested through stratified analyses. Results People neuropsychiatric , cardiovascular sensory impairment/cancer had increased hazards for compared unspecific (Hazard ration (HR) 1.66, 95% confidence interval [CI] 1.13‐2.42; 1.61, CI 1.17‐2.29; 1.32, 1.10‐1.71, respectively). Despite lack statistically significant interaction, high CRP within these patterns, being ε4 carriers heightened multimorbidity. Discussion Individuals neuropsychiatric, cardiovascular, are at ε4, may further increase risk. Identifying such high‐risk groups might allow tailored interventions prevention.

Язык: Английский

Процитировано

114
The impact of dietary macronutrient intake on cognitive function and the brain DOI
Anne-Katrin Muth, Soyoung Q. Park

Clinical Nutrition, Год журнала: 2021, Номер 40(6), С. 3999 - 4010

Опубликована: Май 1, 2021

Язык: Английский

Процитировано

109
Social participation and risk of developing dementia DOI Creative Commons
Andrew Sommerlad, Mika Kivimäki, Eric B. Larson

и другие.

Nature Aging, Год журнала: 2023, Номер 3(5), С. 532 - 545

Опубликована: Май 18, 2023

The increasing number of people with dementia globally illustrates the urgent need to reduce dementia's scale and impact. Lifetime social participation may affect risk by cognitive reserve, through brain maintenance reducing stress improving cerebrovascular health. It therefore have important implications for individual behavior public health policy aimed at burden. Observational study evidence indicates that greater in midlife late life is associated 30–50% lower subsequent risk, although some this not be causal. Social interventions led improved cognition but, partly due short follow-up small numbers participants, no reduction dementia. We summarize linking dementia, discuss potential mechanisms which likely mitigate impact neuropathology brain, consider future clinical prevention interventions. This Review provides evidence-based update on association between interaction authors propose a framework promote as preventative strategy against

Язык: Английский

Процитировано

96
Cardiometabolic multimorbidity, lifestyle behaviours, and cognitive function: a multicohort study DOI Creative Commons
Yinzi Jin, Jersey Liang, Chenlu Hong

и другие.

The Lancet Healthy Longevity, Год журнала: 2023, Номер 4(6), С. e265 - e273

Опубликована: Май 4, 2023

Little is known about the effect of lifestyle factors on cognitive decline related to cardiometabolic multimorbidity. We aimed examine association between multimorbidity and decline, role in this association.We did a pooled multi-cohort study using data from four cohort studies (the Health Retirement Study; English Longitudinal Study Ageing; Survey Health, Ageing Europe; China Study) across 14 countries. Eligible participants were age 50 years older, those who missing information exposure outcomes, or had been diagnosed with dementia Parkinson's disease, excluded. Cardiometabolic was defined as co-occurrence two three diseases, including diabetes, heart stroke. The primary outcome function measured domains, basis mean SD corresponding tests: memory, numeracy, orientation, all available data. A global score created by summing individual scores.The final sample consisted 160 147 individuals (73 846 [46·1%] men 86 301 [53·9%] women) 67·49 (SD 10·43). An increasing number diseases dose-dependently associated (one β=-0·15 [95% CI -0·17 -0·13]; β=-0·37 [-0·40 -0·34]; β=-0·57 [-0·64 -0·50]), comorbid diabetes stroke (β=-0·23 [-0·29 -0·17]) contributing most strongly disease-associated decline. Cognitive disease accelerated physical inactivity cardiometablic p=0·020; p=0·42; p=0·24), excessive alcohol use p=0·016; p=0·65; p=0·50), higher unhealthy p=0·79; p=0·0050; p=0·888).These findings indicated targeted approach for simultaneously developing preventative interventions lifestyles integrated treatment comorbidities delay older people.Major Project National Social Science Fund China, Natural Foundation Medical Board, Young Elite Scientists Sponsorship Program CAST.

Язык: Английский

Процитировано

63
Evaluation of Brain-Body Health in Individuals With Common Neuropsychiatric Disorders DOI
Ye Tian, Maria A. Di Biase, Philip Mosley

и другие.

JAMA Psychiatry, Год журнала: 2023, Номер 80(6), С. 567 - 567

Опубликована: Апрель 26, 2023

Physical health and chronic medical comorbidities are underestimated, inadequately treated, often overlooked in psychiatry. A multiorgan, systemwide characterization of brain body neuropsychiatric disorders may enable systematic evaluation brain-body status patients potentially identify new therapeutic targets.

Язык: Английский

Процитировано

61
Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank DOI
Yi Zhang, Shi-Dong Chen,

Yue‐Ting Deng

и другие.

Nature Human Behaviour, Год журнала: 2023, Номер 7(7), С. 1185 - 1195

Опубликована: Апрель 6, 2023

Язык: Английский

Процитировано

46
Neuroinflammation in Alzheimer disease DOI
Wiesje M. van der Flier, Wiesje M. van der Flier,

Frank Jessen

и другие.

Nature reviews. Immunology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Язык: Английский

Процитировано

43
Statin use and dementia risk: A systematic review and updated meta‐analysis DOI Creative Commons
Fernando Luiz Westphal Filho, Paulo Roberto Moss Lopes, Artur Menegaz de Almeida

и другие.

Alzheimer s & Dementia Translational Research & Clinical Interventions, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

4
Fostering healthy aging: The interdependency of infections, immunity and frailty DOI Creative Commons
Davide Liborio Vetrano, Federico Triolo, Stefania Maggi

и другие.

Ageing Research Reviews, Год журнала: 2021, Номер 69, С. 101351 - 101351

Опубликована: Май 7, 2021

Untangling the interdependency of infections, immunity and frailty may help to clarify their roles in maintenance health aging individuals, recent COVID-19 pandemic has further highlighted such priority. In this scoping review we aimed systematically collect evidence on 1) impact common infections as influenza, pneumonia varicella zoster development, 2) role played by response immunization older adults. Findings are discussed under a unifying framework identify knowledge gaps outline clinical public implications foster healthier aging. Twenty-nine studies (113,863 participants) selected answer first question provided moderately strong an association between physical well cognitive decline – two essential dimensions frailty. Thirteen (34,520 investigating second aim, showed that was associated with impaired immune ages, likely due immunosenescence. However, paucity studies, absence tools predict vaccine efficacy, lack efficacy newer vaccines presence frailty, strongly limit formulation more personalized strategies for The current suggests repeatedly cross each other pathophysiological paths accelerate process vicious circle. Such opens several considerations. First, prevention both conditions pass through life course approach, which includes individual societal aspects. Second, well-functioning system be accomplished preventing vice versa. Third, increasing adherence delay onset maintain homeostasis, beyond infections.

Язык: Английский

Процитировано

61