Vaccines,
Год журнала:
2021,
Номер
9(6), С. 679 - 679
Опубликована: Июнь 21, 2021
This
review
describes
investigations
of
specific
topics
that
lie
within
the
general
subject
HSV1’s
role
in
AD/dementia,
published
last
couple
years.
They
include
studies
on
following:
relationship
HSV1
to
AD
using
neural
stem
cells;
apparent
protective
effects
treatment
infection
or
VZV
with
antivirals
prior
onset
dementia;
putative
involvement
AD/dementia;
possible
human
herpes
virus
6
(HHV6)
AD;
seemingly
reduced
risk
dementia
after
vaccination
diverse
types
vaccine,
and
association
shown
some
vaccine
frequency
reactivation;
anti-HSV
serum
antibodies
supporting
linkage
brain
APOE-ε4
carriers,
between
APOE
cognition,
AD/dementia.
The
conclusions
are
there
is
now
overwhelming
evidence
for
role—probably
causal—in
AD,
when
it
present
further
should
be
made
prevention
disease
by
vaccination,
prolonged
antiviral
before
onset.
Foods,
Год журнала:
2025,
Номер
14(1), С. 101 - 101
Опубликована: Янв. 2, 2025
Alzheimer’s
disease
(AD)
is
marked
by
impaired
cognitive
functions,
particularly
in
learning
and
memory,
owing
to
complex
diverse
mechanisms.
Methionine
restriction
(MR)
has
been
found
exert
a
mitigating
effect
on
brain
oxidative
stress
improve
AD.
However,
the
bidirectional
crosstalk
between
gut
through
which
MR
enhances
memory
AD,
as
well
effects
of
fecal
microbiota
transplantation
(FMT)
from
mice
AD
mice,
remains
underexplored.
In
this
study,
APP/PS1
double
transgenic
were
used
an
FMT
experiment
was
conducted.
16S
rRNA
gene
sequencing,
targeted
metabolomics,
microbial
metabolite
short-chain
fatty
acids
(SCFAs)
feces
samples
analyzed.
The
results
showed
that
reversed
reduction
SCFAs
induced
further
activated
free
acid
receptors,
FFAR2
FFAR3,
transport
protein
MCT1,
thereby
signaling
mitigate
inflammation
enhance
capabilities.
Furthermore,
methionine-restricted
diet
mouse
donors
receiving
ameliorated
ability
SCFAs.
This
study
offers
novel
non-pharmaceutical
intervention
strategies
for
prevention.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(24), С. 9357 - 9357
Опубликована: Дек. 8, 2020
The
development
of
new
therapeutic
approaches
to
diseases
relies
on
the
identification
key
molecular
targets
involved
in
amplifying
disease
processes.
One
such
molecule
is
thioredoxin-interacting
protein
(TXNIP),
also
designated
thioredoxin-binding
protein-2
(TBP-2),
a
member
α-arrestin
family
proteins
and
central
regulator
glucose
lipid
metabolism,
diabetes-associated
vascular
endothelial
dysfunction
inflammation.
TXNIP
sequesters
reduced
thioredoxin
(TRX),
inhibiting
its
function,
resulting
increased
oxidative
stress.
Many
different
cellular
stress
factors
regulate
expression,
including
high
glucose,
endoplasmic
reticulum
stress,
free
radicals,
hypoxia,
nitric
oxide,
insulin,
adenosine-containing
molecules.
directly
inflammatory
activation
through
interaction
with
nucleotide-binding
domain,
leucine-rich-containing
family,
pyrin
domain-containing-3
(NLRP3)
inflammasome
complex.
Neurodegenerative
as
Alzheimer’s
have
significant
pathologies
associated
inflammation,
dysfunctions.
In
addition,
dysfunctions
metabolism
been
brain
diseases,
role
for
neurodegeneration
has
actively
investigated.
this
review,
we
will
focus
current
state
understanding
possible
normal
pathological
functions
nervous
system
from
studies
vitro
neural
cells
brains
humans
experimental
animals
reference
other
studies.
As
can
be
expressed
by
neurons,
microglia,
astrocytes,
cells,
complex
pattern
regulation
function
suggested.
We
examine
data
suggesting
target
neurodegenerative
where
further
research
needed.
Frontiers in Aging Neuroscience,
Год журнала:
2021,
Номер
12
Опубликована: Янв. 12, 2021
The
coronavirus
disease
2019
(COVID-19)
has
become
a
deadly
pandemic
with
surging
mortality
rates
and
no
cure.
COVID-19
is
caused
by
the
severe
acute
respiratory
syndrome
corona
virus
2
(SARS-CoV-2)
range
of
clinical
symptoms,
including
cough,
fever,
chills,
headache,
shortness
breath,
difficulty
breathing,
muscle
pain,
loss
smell
or
taste.
Aged
individuals
compromised
immunity
are
highly
susceptible
to
likelihood
increases
age
presence
comorbidities
such
as
hypertension,
diabetes
mellitus,
cardiovascular
disease,
chronic
obstructive
pulmonary
disease.
Emerging
evidence
suggests
that
highjacks
mitochondria
immune
cells,
replicates
within
mitochondrial
structures,
impairs
dynamics
leading
cell
death.
Mitochondria
powerhouses
largely
involved
in
maintaining
immunity,
homeostasis,
survival/death.
Increasing
from
infected
cells
vulnerable,
vulnerability
age.
purpose
our
article
summarize
role
various
age-related
diabetes,
obesity,
neurological
diseases
increasing
amongst
elderly
COVID-19.
Our
also
highlights
interaction
between
cells.
We
highlight
current
treatments,
lifestyles,
safety
measures
can
help
protect
against
Further
research
urgently
needed
understand
molecular
mechanisms
progression
patients.
Vaccines,
Год журнала:
2021,
Номер
9(6), С. 679 - 679
Опубликована: Июнь 21, 2021
This
review
describes
investigations
of
specific
topics
that
lie
within
the
general
subject
HSV1’s
role
in
AD/dementia,
published
last
couple
years.
They
include
studies
on
following:
relationship
HSV1
to
AD
using
neural
stem
cells;
apparent
protective
effects
treatment
infection
or
VZV
with
antivirals
prior
onset
dementia;
putative
involvement
AD/dementia;
possible
human
herpes
virus
6
(HHV6)
AD;
seemingly
reduced
risk
dementia
after
vaccination
diverse
types
vaccine,
and
association
shown
some
vaccine
frequency
reactivation;
anti-HSV
serum
antibodies
supporting
linkage
brain
APOE-ε4
carriers,
between
APOE
cognition,
AD/dementia.
The
conclusions
are
there
is
now
overwhelming
evidence
for
role—probably
causal—in
AD,
when
it
present
further
should
be
made
prevention
disease
by
vaccination,
prolonged
antiviral
before
onset.
