Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Фев. 23, 2022
Background
The
limbus
is
located
at
a
2-mm-wide
area
between
the
bulbar
conjunctiva
and
cornea
has
been
suggested
to
be
niche
of
corneal
epithelial
stem
cells
immune
cells.
Like
skin
intestines,
also
an
important
mucosal
surface,
on
play
critical
roles
in
surveillance
ensure
barrier
surface
homeostasis
protection
from
various
environmental
damage
infections.
Single-cell
RNA
sequencing
(scRNA-seq)
analysis
protein
tyrosine
phosphatase
receptor
type
C
positive
(PTPRC
+
)
hematopoietic
could
provide
single
cell
atlas
all
subsets.
Methods
We
performed
single-cell
generate
transcriptomic
profile
for
804
sort-purified
three
healthy
donors.
Results
Our
identified
primary
pattern
multiple
subtypes,
including
naive
T
cells,
antiviral
effector
CD8
innate
such
as
IDO1
mature
regulatory
dendritic
(mregDCs),
macrophages,
monocytes,
basophils
human
limbus.
Conclusion
Overall,
limbal
possible
contribution
these
adaptive
response
cornea.
Immunosenescence,
the
slow
degradation
of
immune
function
over
time
that
is
a
hallmark
and
driver
aging,
makes
older
people
much
more
likely
to
be
killed
by
common
infections
(such
as
flu)
than
young
adults,
but
it
also
contributes
greatly
rates
chronic
inflammation
in
later
life.
Such
micro
nutrients
are
crucial
for
modulating
effective
responses
their
deficiencies
have
been
associated
with
dysfunctional
immunity
elderly.
In
this
review,
we
specifically
focused
on
contribution
major
(Vitamins
A,
D
E,
Vitamin
C;
Zinc
Selenium)
immunomodulators
ageing
population
especially
related
inflame-ageing
process
including
autoimmunity.
This
review
will
cover
these
hologenomic
interactions,
how
can
modulate
cell
and/or
cytokine
production
benefit
hosts
healthy
mucous-associated
along
sustainable
immunologic
homeostasis.
For
example,
points
out
modulatory
effects
vitamin
both
innate
adaptive
immunity,
specific
focus
its
ability
suppress
pro-inflammatory
cytokines
synthesis
while
enhancing
regulatory
T-cell
function.
same
context,
zinc
described
important
nutrient
thymic
differentiation
exhibits
immunomodulatory
functions
decreasing
inflammation.
addition,
go
increase
systemic
low-grade
and,
inflammaging
well
actually
enhance
autoimmune
pathologies
old
age.
It
assesses
potential
role
additional
targeted
nutritional
supplementation
counteract
effects,
promoting
wider
resilience
adults.
collates
current
evidence
highlights
adequate
intake
autoimmunity
during
ageing,
providing
plausible
origins
interventions
promote
aging.
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(14)
Опубликована: Март 31, 2025
Splenic
T
cells
are
pivotal
to
the
immune
system,
yet
their
function
deteriorates
with
age.
To
elucidate
specific
aspects
of
cell
biology
affected
by
aging,
we
conducted
a
comprehensive
multi–time
point
single-cell
RNA
sequencing
study,
complemented
Assay
for
Transposase
Accessible
Chromatin
(ATAC)
and
repertoire
(TCR)
on
splenic
from
mice
across
10
different
age
groups.
This
map
age-related
changes
in
distribution
lineages
functional
states
reveals
broad
composition,
including
prominent
enrichment
Gzmk+
aged
mice,
encompassing
both
CD4+
CD8+
subsets.
Notably,
there
is
marked
decrease
TCR
diversity
populations
mice.
We
identified
key
pathways
that
may
underlie
perturbation
functions
supporting
cytotoxic
clonal
expansion
study
provides
insights
into
aging
process
also
highlights
potential
targets
therapeutic
intervention
enhance
elderly.
The
dataset
should
serve
as
resource
further
research
dysfunction
identifying
strategies.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
T
cells
and
their
cell
receptors
(TCRs)
play
crucial
roles
in
the
adaptive
immune
system's
response
against
pathogens
tumors.
However,
immunosenescence,
characterized
by
declining
function
quantity
with
age,
significantly
impairs
antitumor
immunity.
Recent
years
have
witnessed
remarkable
progress
cell-based
cancer
treatments,
driven
a
deeper
understanding
of
biology
innovative
screening
technologies.
This
review
comprehensively
examines
maturation
mechanisms,
cell-mediated
responses,
implications
thymic
involution
on
diversity
prognosis.
We
discuss
recent
advances
adoptive
therapies,
including
tumor-infiltrating
lymphocyte
(TIL)
therapy,
engineered
receptor
(TCR-T)
chimeric
antigen
(CAR-T)
therapy.
Notably,
we
highlight
emerging
DNA-encoded
library
technologies
mammalian
for
high-throughput
TCR-antigen
interactions,
which
are
revolutionizing
discovery
novel
tumor
antigens
optimization
TCR
affinity.
The
also
explores
strategies
to
overcome
challenges
solid
microenvironment
approaches
enhance
efficacy
As
our
deepens
advances,
immunotherapies
show
increasing
promise
delivering
durable
clinical
benefits
broader
patient
population.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Фев. 23, 2022
Background
The
limbus
is
located
at
a
2-mm-wide
area
between
the
bulbar
conjunctiva
and
cornea
has
been
suggested
to
be
niche
of
corneal
epithelial
stem
cells
immune
cells.
Like
skin
intestines,
also
an
important
mucosal
surface,
on
play
critical
roles
in
surveillance
ensure
barrier
surface
homeostasis
protection
from
various
environmental
damage
infections.
Single-cell
RNA
sequencing
(scRNA-seq)
analysis
protein
tyrosine
phosphatase
receptor
type
C
positive
(PTPRC
+
)
hematopoietic
could
provide
single
cell
atlas
all
subsets.
Methods
We
performed
single-cell
generate
transcriptomic
profile
for
804
sort-purified
three
healthy
donors.
Results
Our
identified
primary
pattern
multiple
subtypes,
including
naive
T
cells,
antiviral
effector
CD8
innate
such
as
IDO1
mature
regulatory
dendritic
(mregDCs),
macrophages,
monocytes,
basophils
human
limbus.
Conclusion
Overall,
limbal
possible
contribution
these
adaptive
response
cornea.
