Adipose tissue aging: mechanisms and therapeutic implications

Cell Death and Disease, Год журнала: 2022, Номер 13(4)

Опубликована: Апрель 4, 2022

Abstract Adipose tissue, which is the crucial energy reservoir and endocrine organ for maintenance of systemic glucose, lipid, homeostasis, undergoes significant changes during aging. These cause physiological declines age-related disease in elderly population. Here, we review adipose tissue at multiple levels highlight underlying mechanisms regulating aging process. We also discuss pathogenic pathways fat dysfunctions their negative consequences, such as dyslipidemia, chronic general inflammation, insulin resistance, type 2 diabetes (T2D). Age-related involve redistribution deposits composition, parallel with functional decline adipocyte progenitors accumulation senescent cells. Multiple induce defective adipogenesis, aberrant adipocytokine production, leading to dysfunction. Changes gene expression extracellular signaling molecules regulate process through various pathways. In addition, impacts other organs that are infiltrated by lipids, leads metabolic system disruption, acceleration. Moreover, studies have indicated an early onset event a potential target extend lifespan. Together, suggest plays key role therapeutic treatment disease, deserves further study advance relevant knowledge.

Язык: Английский

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Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Окт. 13, 2023

Aging is a progressive and irreversible pathophysiological process that manifests as the decline in tissue cellular functions, along with significant increase risk of various aging-related diseases, including metabolic diseases. While advances modern medicine have significantly promoted human health extended lifespan, diseases such obesity type 2 diabetes among older adults pose major challenge to global public societies age. Therefore, understanding complex interaction between factors crucial for promoting well-being healthy aging. This review article explores environmental behavioral associated their impact on The environment, an obesogenic environment exposure toxins, strongly correlated rising prevalence its comorbidities. Behavioral factors, diet, physical activity, smoking, alcohol consumption, sleep patterns, influence throughout Public interventions targeting modifiable can effectively promote healthier lifestyles prevent Collaboration government agencies, healthcare providers community organizations essential implementing these creating supportive environments foster

Язык: Английский

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Age-related bone diseases: Role of inflammaging

Journal of Autoimmunity, Год журнала: 2024, Номер 143, С. 103169 - 103169

Опубликована: Фев. 1, 2024

Язык: Английский

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Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102428 - 102428

Опубликована: Июль 20, 2024

Язык: Английский

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Integrating DNA Methylation Measures of Biological Aging into Social Determinants of Health Research

Current Environmental Health Reports, Год журнала: 2022, Номер 9(2), С. 196 - 210

Опубликована: Фев. 18, 2022

Язык: Английский

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SIRT7 in the aging process

Cellular and Molecular Life Sciences, Год журнала: 2022, Номер 79(6)

Опубликована: Май 18, 2022

Aging is the result of accumulation a wide variety molecular and cellular damage over time. This has been associated with number features termed hallmarks aging, including genomic instability, loss proteostasis, telomere attrition, dysregulated nutrient sensing, mitochondrial dysfunction, senescence, stem cell exhaustion, impaired intercellular communication. On other hand, sirtuins are enzymes an important role in aging life extension, which humans have seven paralogs (SIRT1 to SIRT7). SIRT7 least studied sirtuin date, but it reported serve functions, such as promoting ribosomal RNA expression, aiding DNA repair, regulating chromatin compaction. Several studies established close relationship between age-related processes, knowledge this area still scarce. Therefore, purpose review was analyze how each well some age-associated diseases, cardiovascular obesity, osteoporosis, cancer.

Язык: Английский

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The Role of Obesity and Diabetes in Dementia

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(16), С. 9267 - 9267

Опубликована: Авг. 17, 2022

Chronic conditions such as obesity, diabetes, and dementia are increasing in the United States (US) population. Knowledge of these chronic conditions, preventative measures, proper management tactics is important critical to preventing disease. The overlap between becoming further elucidated. These share a similar origin through components age, gender, genetic epigenetic predispositions, depression, high-fat Western diet (WD) that all contribute inflammatory state associated with development dementia. This leads dysregulation food intake insulin resistance. Obesity often cornerstone diabetes and, subsequently, case type 2 mellitus (T2DM), progression "type 3 (T3DM)". depression closely diabetes. However, can be avoided lifestyle modifications, by switching plant-based (e.g., Mediterranean (MD)), physical activity. Diet exercise not only treatment options. There several surgical pharmacological interventions available for prevention. Current future research within each fields warranted offers chance new options better understanding pathogenesis condition.

Язык: Английский

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GLP1 Receptor Agonists—Effects beyond Obesity and Diabetes

Cells, Год журнала: 2023, Номер 13(1), С. 65 - 65

Опубликована: Дек. 28, 2023

Glucagon-like peptide-1 receptor agonists (GLP1RA) have been transformative for patients and clinicians in treating type-2 diabetes obesity. Drugs of this class, the bioavailability which is continuously improving, enable weight loss control blood glucose with minimal unwanted side effects. Since adopting GLP1RA metabolic diseases, animal clinical studies revealed their beneficial effects on several other pathologies, including cardiovascular neurodegeneration, kidney disease, cancer. A notable commonality between these diseases association older age. Clinical trials preclinical data suggest that may improve outcomes aging-related diseases. Some benefits be indirect due to obesity metabolism. However, there building evidence also act directly multiple organs implicated pathology. This review aims compile reporting discuss potential underlying mechanisms.

Язык: Английский

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Obesity-associated changes in molecular biology of primary breast cancer

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июль 21, 2023

Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on biology remains understudied humans. This study investigates how the untreated primary differs according to patients' body mass index (BMI) using data from >2,000 patients. We identify several genomic alterations that are differentially prevalent overweight or obese patients compared lean report evidence supporting ageing accelerating effect obesity at genetic level. show BMI-associated differences bulk transcriptomic profile subtle, while single cell profiling allows detection more pronounced changes different compartments. These analyses further reveal elevated unresolved inflammation tumor microenvironment obesity, distinct characteristics contingent estrogen receptor status. Collectively, our imply inflammaging-like phenotype. conclude patient adiposity may play a significant role heterogeneity should be considered for treatment tailoring.

Язык: Английский

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Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Journal of Alzheimer s Disease, Год журнала: 2023, Номер 96(4), С. 1353 - 1382

Опубликована: Ноя. 7, 2023

Diet is an important nonpharmacological risk-modifying factor for Alzheimer's disease (AD). The approaches used here to assess diet's role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational laboratory studies. Ecological studies have identified fat, meat, obesity from high-energy diets as factors reported that rates peak about 15-20 years after national dietary changes. Observational compared Western pattern with those Dietary Approaches Stop Hypertension (DASH), Mediterranean (MedDi), Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) diets. Those including higher consumption saturated total fats, ultraprocessed foods a lower fruits, legumes, nuts, omega-3 fatty acids, vegetables, whole grains. Diet-induced associated significant inflammation, insulin resistance, oxidative stress, elevated homocysteine, advanced glycation end products, trimethylamine N-oxide. molecular mechanisms by which bioactive components specific affect are discussed. Given most countries' entrenched food supply systems, upward trends would be hard reverse. However, people willing able, low-animal product diet plenty anti-inflammatory, low-glycemic load may helpful.

Язык: Английский

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