Biological age is increased by stress and restored upon recovery

Cell Metabolism, Год журнала: 2023, Номер 35(5), С. 807 - 820.e5

Опубликована: Апрель 21, 2023

Язык: Английский

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The multiple roles of life stress in metabolic disorders

Nature Reviews Endocrinology, Год журнала: 2022, Номер 19(1), С. 10 - 27

Опубликована: Окт. 12, 2022

Язык: Английский

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Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(9)

Опубликована: Фев. 21, 2023

Biomarkers developed from DNA methylation (DNAm) data are of growing interest as predictors health outcomes and mortality in older populations. However, it is unknown how epigenetic aging fits within the context known socioeconomic behavioral associations with aging-related a large, population-based, diverse sample. This study uses representative, panel US adults to examine relationship between DNAm-based age acceleration measures prediction cross-sectional longitudinal mortality. We whether recent improvements these scores, using principal component (PC)-based designed remove some technical noise unreliability measurement, improve predictive capability measures. also well perform against well-known such demographics, SES, behaviors. In our sample, calculated “second third generation clocks,” PhenoAge, GrimAge, DunedinPACE, consistently significant predictor including cognitive dysfunction, functional limitations chronic conditions assessed 2 y after DNAm 4-y PC-based do not significantly change or compared earlier versions While usefulness later life quite clear, other factors mental health, behaviors remain equally, if more robust, outcomes.

Язык: Английский

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In utero exposure to the Great Depression is reflected in late-life epigenetic aging signatures

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(46)

Опубликована: Ноя. 8, 2022

Research on maternal-fetal epigenetic programming argues that adverse exposures to the intrauterine environment can have long-term effects adult morbidity and mortality. However, causal research in humans at a population level is rare often unable separate from conditions postnatal period may continue impact child development. In this study, we used quasi-natural experiment leverages state-year variation economic shocks during Great Depression examine effect of environmental early life late-life accelerated aging for 832 participants US Health Retirement Study (HRS). HRS first population-representative study collect epigenome-wide DNA methylation data has sample size geographic necessary exploit quasi-random state environments, which expands possibilities epigenetics. Our findings suggest exposure changing 1930s had lasting impacts next-generation signatures were developed predict mortality risk (GrimAge) physiological decline (DunedinPoAm). We show these are localized utero specifically as opposed preconception, postnatal, childhood, or adolescent periods. After evaluating endogenous shifts fertility related Depression-era birth cohorts, conclude likely represent lower bound estimates true shock aging.

Язык: Английский

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Association of Race and Poverty Status With DNA Methylation–Based Age

JAMA Network Open, Год журнала: 2023, Номер 6(4), С. e236340 - e236340

Опубликована: Апрель 7, 2023

Importance The Dunedin Pace of Aging Calculated From the Epigenome (DunedinPACE) measure is a newly constructed DNA methylation (DNAm) biomarker associated with morbidity, mortality, and adverse childhood experiences in several cohorts European ancestry. However, there are few studies DunedinPACE among socioeconomically racially diverse longitudinal assessments. Objective To investigate association race poverty status scores middle-aged cohort African American White participants. Design, Setting, Participants This study used data from Healthy Neighborhoods Diversity Across Life Span (HANDLS) study. HANDLS population-based adults aged 30 to 64 years at baseline Baltimore, Maryland, follow-up approximately every 5 years. current was restricted 470 participants blood samples 2 time points: August 14, 2004, June 22, 2009 (visit 1), 23, 2009, September 12, 2017 2). Genome-wide DNAm assessed visit 1 (chronological age, 30-64 years) 2. Data were analyzed March 18, 2022, February 9, 2023. Main Outcomes Measures estimated for each participant visits. values scaled mean 1, interpretable reference rate year biological aging per chronological aging. Linear mixed-model regression analysis examine trajectories by race, sex, status. Results Among participants, (SD) age 48.7 (8.7) balanced sex (238 [50.6%] men 232 [49.4%] women), (237 [50.4%] 233 [49.6%] White), (236 [50.2%] living below level 234 [49.8%] above level). between visits 5.1 (1.5) Overall, score 1.07 (0.14), representing 7% faster pace than mixed-effects revealed an 2-way interaction (White household income level: β = 0.0665; 95% CI, 0.0298-0.1031; P < .001) significantly higher quadratic (age squared: −0.0113; −0.0212 −0.0013; .03) scores. Conclusions Relevance In this study, These findings suggest that varies as social determinants health. Consequently, measures accelerated should be based on representative samples.

Язык: Английский

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The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 153, С. 105359 - 105359

Опубликована: Авг. 15, 2023

Язык: Английский

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Epigenetic Aging and Racialized, Economic, and Environmental Injustice

JAMA Network Open, Год журнала: 2024, Номер 7(7), С. e2421832 - e2421832

Опубликована: Июль 29, 2024

Importance Epigenetic age acceleration is associated with exposure to social and economic adversity may increase the risk of premature morbidity mortality. However, no studies have included measures structural racism, few compared estimates within or across first second generation epigenetic clocks. Objective To determine whether positively exposures diverse racialized, economic, environmental injustice measured at different levels time periods. Design, Setting, Participants This cross-sectional study used data from My Body Story (MBMS) between August 8, 2008, December 31, 2010, examination 5 Multi-Ethnic Atherosclerosis Study (MESA) April 1, February 29, 2012. In MBMS, DNA extraction was performed in 2021; linkage MBMS MESA, 2022. US-born individuals were randomly selected 4 community health centers Boston, Massachusetts (MBMS), field sites Baltimore, Maryland; Forsyth County, North Carolina; New York City, York; St Paul, Minnesota (MESA). Data analyzed November 13, 2021, 2023. Main Outcomes Measures Ten clocks (6 first-generation second-generation), computed using methylation (DNAm) blood spots purified monocytes Results The population 293 participants (109 men [37.2%], 184 women [62.8%]; mean [SD] age, 49.0 [8.0] years) 224 Black non-Hispanic 69 White 975 MESA (492 [50.5%], 483 [49.5%]; 70.0 [9.3] 229 non-Hispanic, 191 Hispanic, 555 participants. Of these, 140 (11.0%) exhibited accelerated aging for all whose are interpretable on (years) scale. Among participants, being born a Jim Crow state by 0.14 (95% CI, 0.003-0.27) SDs birth conservatism 0.06 0.01-0.12) SDs, pooling Low parental educational level acceleration, clocks, both (0.24 [95% 0.08-0.39] SDs) (0.27 0.03-0.51] Adult impoverishment pooled second-generation among (Black 0.01-0.12] SDs; 0.07 0.01-0.14] 0.05 0.01-0.08] SDs). Conclusions Relevance findings this suggest that racialized injustice, potentially contributing well-documented inequities Future research should test hypothesis be one biological mechanisms underlying elevated mortality groups subjected injustice.

Язык: Английский

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Utilizing epigenetics to study the shared nature of development and biological aging across the lifespan

npj Science of Learning, Год журнала: 2024, Номер 9(1)

Опубликована: Март 21, 2024

Recently, biological aging has been quantified in DNA-methylation samples of older adults and applied as so-called "methylation profile scores" (MPSs) separate target samples, including children. This nascent research indicates that (1) can be early the life course, decades before onset aging-related disease, (2) is affected by common environmental predictors childhood development, (3) shows overlap with "developmental processes" (e.g., puberty). Because MPSs were computed using algorithms developed adults, these studies indicate a molecular link between environments, adult aging. Yet, if used to connect development aging, previous only traveled one way, deriving applying them Researchers have not yet epigenetic measures reflect pace child tested whether resulting are associated physical psychological In this perspective I posit combining new quantifications power address fundamental questions about span: How experience related adulthood? And what aging?

Язык: Английский

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Stability of Aging‐ and Cognition‐Related Methylation Profile Scores Across Two Waves in Children and Adolescents

Child Development, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

DNA-methylation profile scores (MPSs) index biology relevant for lifelong physical and cognitive health, but information on their longitudinal stability in childhood is lacking. Using two waves of data collected from 2014 to 2022 (Mlag between = 2.41 years) N 407 participants (Mage 12.05 years, 51% female, 60% White), test-retest correlations were estimated four salivary MPSs related aging (PhenoAgeAccel, GrimAgeAccel, DunedinPACE), function (Epigenetic-g). varied (test-retest rs 0.38 0.76). did not differ children exposed the COVID-19 pandemic, race-ethnic sex differences apparent. Further research necessary understand which environmental perturbations impact trajectories when are most sensitive those impacts.

Язык: Английский

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To promote healthy aging, focus on the environment

Nature Aging, Год журнала: 2023, Номер 3(11), С. 1334 - 1344

Опубликована: Ноя. 9, 2023

Язык: Английский

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