Influence of human gut microbiome on the healthy and the neurodegenerative aging

Experimental Gerontology, Год журнала: 2024, Номер 194, С. 112497 - 112497

Опубликована: Июнь 27, 2024

The gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. microbial diversity of human decreases aging process and, as consequence, several mechanisms increase, such oxidative stress, mitochondrial dysfunction, inflammatory response, and dysbiosis. Moreover, evidence indicates that neurodegeneration are closely related; consequently, may serve novel marker elderly. In this narrative study, we investigated how changes composition occur influence to various neuropathological disorders, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), Parkinson's (PD); which possible govern relationship between impairment. addition, studies suggest be potential target improve hallmarks promote healthy cognition; therefore, current future therapeutic interventions have been also reviewed.

Язык: Английский

---

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Phytotherapy Research, Год журнала: 2024, Номер 38(3), С. 1400 - 1461

Опубликована: Янв. 17, 2024

Abstract Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for development of new effective therapeutics treat them. Stilbenes, with resveratrol attracting most attention, example multi‐target compounds promising therapeutic potential broad array neuropsychiatric and neurological conditions. This review is comprehensive summary current state research on stilbenes several such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, neurodegenerative disorders. We describe discuss results both vitro vivo studies. The majority studies concentrate resveratrol, limited findings exploring other pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic derivatives. Overall, although extensive preclinical show benefits various central nervous system clinical evidence their efficacy largely missing.

Язык: Английский

---

Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes

Life Sciences, Год журнала: 2024, Номер 342, С. 122537 - 122537

Опубликована: Фев. 29, 2024

Язык: Английский

---

The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 16, 2024

Importance Research is beginning to elucidate the sophisticated mechanisms underlying microbiota-gut-brain-immune interface, moving from primarily animal models human studies. Findings support dynamic relationships between gut microbiota as an ecosystem (microbiome) within (host) and its intersection with host immune nervous systems. Adding this effects on epigenetic regulation of gene expression further complicates strengthens response. At heart inflammation, which manifests in a variety pathologies including neurodegenerative diseases such Alzheimer’s disease, Parkinson’s Multiple Sclerosis (MS). Observations Generally, research date limited has focused bacteria, likely due simplicity cost-effectiveness 16s rRNA sequencing, despite lower resolution inability determine functional ability/alterations. However, omits all other fungi, viruses, phages, are emerging key members microbiome. Much been done pre-clinical and/or small studies more developed parts world. The observed promising but cannot be considered reliable or generalizable at time. Specifically, causal determined currently. More followed by then little MS. data for MS encouraging this. Conclusions relevance While still nascent, interface may missing link, hampered our progress understanding, let alone preventing, managing, putting into remission diseases. Relationships must first established humans, have shown poorly translate complex physiology environments, especially when investigating microbiome where often overly simplistic. Only can robust conducted humans using mechanistic model

Язык: Английский

---

Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases

Foods, Год журнала: 2025, Номер 14(3), С. 347 - 347

Опубликована: Янв. 21, 2025

Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations

Язык: Английский

---