Cell Reports,
Год журнала:
2023,
Номер
42(9), С. 113141 - 113141
Опубликована: Сен. 1, 2023
Emerging
evidence
suggests
that
peripheral
immune
cells
contribute
to
Alzheimer's
disease
(AD)
neuropathogenesis.
Among
these,
mast
are
known
for
their
functions
in
allergic
reactions
and
neuroinflammation;
however,
little
is
about
role
AD.
Here,
we
crossed
5XFAD
mice
with
cell-deficient
strains
observed
the
effects
on
AD-related
neuropathology
cognitive
impairment.
We
found
cell
depletion
improved
contextual
fear
conditioning
without
affecting
cued
conditioning,
anxiety-like
behavior,
or
amyloid
burden.
Furthermore,
led
an
upregulation
of
transcriptomic
signatures
putatively
protective
disease-associated
microglia
resulted
reduced
markers
indicative
reactive
astrocytes.
hypothesize
a
system
bidirectional
communication
between
dural
brain,
where
respond
signals
from
brain
environment
by
expressing
immune-regulatory
mediators,
impacting
cognition
glial
function.
These
findings
highlight
as
potential
therapeutic
targets
Neural Regeneration Research,
Год журнала:
2022,
Номер
18(4), С. 708 - 708
Опубликована: Сен. 21, 2022
Alzheimer's
disease
is
characterized
by
sustained
neuroinflammation
leading
to
memory
loss
and
cognitive
decline.
The
past
decade
has
witnessed
tremendous
efforts
in
research;
however,
no
effective
treatment
available
prevent
progression.
An
increasing
body
of
evidence
suggests
that
plays
an
important
role
pathogenesis,
alongside
the
classical
pathological
hallmarks
such
as
misfolded
aggregated
proteins
(e.g.,
amyloid-beta
tau).
Firstly,
this
review
summarized
clinical
characteristics
disease.
Secondly,
we
outlined
key
aspects
glial
cell-associated
inflammation
pathogenesis
provided
latest
on
roles
microglia
astrocytes
pathology.
Then,
revealed
double-edged
nature
inflammatory
cytokines
inflammasomes
In
addition,
potential
therapeutic
innate
immunity
for
were
also
discussed
through
these
mechanisms.
final
section,
remaining
problems
according
current
research
status
discussed.
Cells,
Год журнала:
2022,
Номер
11(17), С. 2728 - 2728
Опубликована: Сен. 1, 2022
Alzheimer’s
disease
(AD)
is
the
most
common
form
of
dementia
worldwide,
with
a
complex,
poorly
understood
pathogenesis.
Cerebral
atrophy,
amyloid-β
(Aβ)
plaques,
and
neurofibrillary
tangles
represent
main
pathological
hallmarks
AD
brain.
Recently,
neuroinflammation
has
been
recognized
as
prominent
feature
brain
substantial
evidence
suggests
that
inflammatory
response
modulates
progression.
Additionally,
dysregulation
calcium
(Ca2+)
homeostasis
represents
another
early
factor
involved
in
pathogenesis,
intracellular
Ca2+
concentration
essential
to
ensure
proper
cellular
neuronal
functions.
Although
growing
supports
involvement
mechanisms
neurodegeneration-related
processes,
scant
data
are
available
on
its
contribution
microglia
astrocytes
functioning,
both
health
throughout
continuum.
Nevertheless,
AD-related
aberrant
signalling
crucially
underpinning
neuroinflammatory
processes
that,
turn,
impact
function.
In
this
light,
we
attempted
provide
an
overview
current
understanding
interactions
between
glia
cells-mediated
responses
molecular
AD.
IEEE Transactions on Neural Systems and Rehabilitation Engineering,
Год журнала:
2024,
Номер
32, С. 696 - 707
Опубликована: Янв. 1, 2024
Alzheimer's
Disease
(AD)
is
a
widespread,
chronic,
irreversible,
and
degenerative
condition,
its
early
detection
during
the
prodromal
stage
of
utmost
importance.
Typically,
AD
studies
rely
on
single
data
modalities,
such
as
MRI
or
PET,
for
making
predictions.
Nevertheless,
combining
metabolic
structural
can
offer
comprehensive
perspective
staging
analysis.
To
address
this
goal,
paper
introduces
an
innovative
multi-modal
fusion-based
approach
named
Dual-3DM
3
-AD.
This
model
proposed
accurate
diagnosis
by
considering
both
PET
image
scans.
Initially,
we
pre-process
images
in
terms
noise
reduction,
skull
stripping
3D
conversion
using
Quaternion
Non-local
Means
Denoising
Algorithm
(QNLM),
Morphology
function
Block
Divider
Model
(BDM),
respectively,
which
enhances
quality.
Furthermore,
have
adapted
Mixed-transformer
with
Furthered
U-Net
performing
semantic
segmentation
minimizing
complexity.
-AD
consisted
multi-scale
feature
extraction
module
extracting
appropriate
features
from
segmented
images.
The
extracted
are
then
aggregated
Densely
Connected
Feature
Aggregator
Module
(DCFAM)
to
utilize
features.
Finally,
multi-head
attention
mechanism
dimensionality
softmax
layer
applied
multi-class
diagnosis.
compared
several
baseline
approaches
help
performance
metrics.
final
results
unveil
that
work
achieves
98%
accuracy,
97.8%
sensitivity,
97.5%
specificity,
98.2%
f-measure,
better
ROC
curves,
outperforms
other
existing
models
multiclass
Biomedicines,
Год журнала:
2022,
Номер
10(5), С. 1206 - 1206
Опубликована: Май 23, 2022
Astrocytes
are
essential
for
normal
brain
development
and
functioning.
They
respond
to
injury
disease
through
a
process
referred
as
reactive
astrogliosis,
where
the
reactivity
is
highly
heterogenous
context-dependent.
Reactive
astrocytes
active
contributors
pathology
can
exert
beneficial,
detrimental,
or
mixed
effects
following
insults.
Transforming
growth
factor-β
(TGF-β)
has
been
identified
one
of
key
factors
regulating
astrocyte
reactivity.
The
genetic
pharmacological
manipulation
TGF-β
signaling
pathway
in
animal
models
central
nervous
system
(CNS)
alters
pathological
functional
outcomes.
This
review
aims
provide
recent
understanding
regarding
injury,
aging,
neurodegeneration.
Further,
it
explores
how
modulates
function
context
CNS
injury.
Neuroscience Bulletin,
Год журнала:
2022,
Номер
38(6), С. 677 - 691
Опубликована: Март 19, 2022
Abstract
Since
the
establishment
of
biomarker-based
A-T-N
(Amyloid/Tau/Neurodegeneration)
framework
in
Alzheimer’s
disease
(AD),
diagnosis
AD
has
become
more
precise,
and
cerebrospinal
fluid
tests
positron
emission
tomography
examinations
based
on
this
have
widely
accepted.
However,
does
not
encompass
whole
spectrum
pathologies,
problems
with
invasiveness
high
cost
limit
application
above
diagnostic
methods
aimed
at
central
nervous
system.
Therefore,
we
suggest
addition
an
“X”
to
a
focus
peripheral
biomarkers
AD.
In
review,
retrospectively
describe
recent
progress
A-T-N-X
framework,
analyze
problems,
present
our
perspectives
Hippocampus,
Год журнала:
2023,
Номер
33(4), С. 307 - 321
Опубликована: Фев. 7, 2023
Abstract
Alzheimer's
disease
(AD)
is
the
most
common
form
of
age‐related
dementia,
characterized
by
progressive
memory
loss
and
cognitive
disturbances.
The
hippocampus,
where
adult
hippocampal
neurogenesis
(AHN),
a
relatively
novel
brain
plasticity
that
refers
to
birth
new
neurons,
occurs,
one
first
regions
be
affected
in
AD
patients.
Recent
studies
showed
AHN
persists
throughout
life
humans,
but
it
drops
sharply
Next
questions
consider
would
whether
impairment
contributing
factor
learning
restoring
could
ameliorate
or
delay
dysfunction.
Here,
we
outline
discuss
current
knowledge
about
state
patients,
as
potentially
relevant
mechanism
underlying
deficits
AD,
therapeutic
potential
activating
mechanisms
AD.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
158, С. 114206 - 114206
Опубликована: Янв. 5, 2023
The
term
type
III
diabetes
(T3DM)
has
been
proposed
for
Alzheimer's
disease
(AD)
due
to
the
shared
molecular
and
cellular
features
between
2
(T2DM)
insulin
resistance-associated
memory
deficits
cognitive
decline
in
elderly
individuals.
Astrocytes
elicit
neuroprotective
or
deleterious
effects
AD
progression
severity.
Patients
with
T2DM
are
at
a
high
risk
of
impairment,
targeting
astrocytes
might
be
promising
alleviating
neurodegeneration
diabetic
brain.
Recent
studies
focusing
on
cell-specific
activities
brain
have
revealed
important
role
metabolism
(e.g.,
glucose
metabolism,
lipid
metabolism),
neurovascular
coupling,
synapses,
synaptic
plasticity.
In
this
review,
we
discuss
how
their
dysfunction
result
multiple
pathological
clinical
from
metabolic
perspective
potential
comorbid
mechanism
these
two
diseases
astrocytes.
