Ageing Research Reviews, Год журнала: 2023, Номер 92, С. 102098 - 102098
Опубликована: Окт. 30, 2023
Язык: Английский
RSC Advances, Год журнала: 2024, Номер 14(16), С. 11057 - 11088
Опубликована: Янв. 1, 2024
Alzheimer has many crucial factors that should be considered in order to get better results from clinical trials. Benzimidazole and its isosteres represent significant scaffolds for designing potential multi-target anti-alzheimer molecules.
Язык: Английский
Процитировано
22
Cellular and Molecular Neurobiology, Год журнала: 2024, Номер 44(1)
Опубликована: Окт. 8, 2024
The increasing prevalence of neurological disorders such as Alzheimer's, Parkinson's, and multiple sclerosis presents a significant global health challenge. Despite extensive research, the precise mechanisms underlying these conditions remain elusive, with current treatments primarily addressing symptoms rather than root causes. Emerging evidence suggests that gut permeability kynurenine pathway are involved in pathogenesis conditions, offering promising targets for novel therapeutic preventive strategies. Gut refers to intestinal lining's ability selectively allow essential nutrients into bloodstream while blocking harmful substances. Various factors, including poor diet, stress, infections, genetic predispositions, can compromise integrity, leading increased permeability. This condition facilitates translocation toxins bacteria systemic circulation, triggering widespread inflammation impacts via gut-brain axis. axis (GBA) is complex communication network between central nervous system. Dysbiosis, an imbalance microbiota, increase inflammation, exacerbating neuroinflammation-a key factor disorders. pathway, primary route tryptophan metabolism, significantly implicated this process. Dysregulation context leads production neurotoxic metabolites, quinolinic acid, which contribute neuronal damage progression narrative review highlights potential progress understanding mechanisms. Interventions targeting maintaining balanced microbiota through probiotics, lifestyle modifications show promise reducing neuroinflammation supporting brain health. In addition, pharmacological approaches aimed at modulating directly, inhibitors indoleamine 2,3-dioxygenase, offer avenues new treatments. Understanding interconnected pathways crucial developing effective strategies prevent manage
Язык: Английский
Процитировано
21
Future Science OA, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 31, 2025
Alzheimer's disease is a developing public health concern in aging communities that affects sizable section of the global population. The risk increases with age; it one-third males and two-thirds women. This research attempts to assess effect nano-selenium thymoquinone on Nrf2 gene expression levels (AD). There were five identical groups 50 albino male rats: control group was healthy; an AD positive group; received (5 mg/kg); (2 both. duration treatment 4 weeks. brain tissues evaluated using real-time PCR. mean nano-selenium-treated rats, thymoquinone-treated rats given both treatments all increased significantly compared no treatment. study showed elevated AD.
Язык: Английский
Процитировано
5
Journal of the American Chemical Society, Год журнала: 2023, Номер 145(50), С. 27748 - 27756
Опубликована: Дек. 5, 2023
Aggregation-induced emission (AIE) enables "Turn-On" imaging generally through single aggregation of the AIE luminogen (AIEgen). Dual aggregrations AIEgen might further enhance intensity and consequent sensitivity. Herein, we rationally designed a near-infrared (NIR) Ac-Trp-Glu-His-Asp-Cys(StBu)-Pra(QMT)-CBT (QMT-CBT) which, upon caspase1 (Cas1) activation, underwent CBT-Cys click reaction to form cyclic dimers QMT-Dimer (the first aggregation) assembled into nanoparticles second aggregation), turning signal "on" for enhanced Alzheimer's disease (AD). Molecular dynamics simulations validated that fluorogen QMT in QMT-NPs stacked much tighter with each other than aggregates control compound Ac-Trp-Glu-His-Asp-Cys(tBu)-Pra(QMT)-CBT (QMT-CBT-Ctrl). aggregations rendered 1.9-, 1.7-, 1.4-fold fluorescence intensities its vitro, cells, living AD mouse model, respectively. We anticipate this smart be used sensitive diagnosis clinic near future.
Язык: Английский
Процитировано
44
Nano-Micro Letters, Год журнала: 2023, Номер 16(1)
Опубликована: Дек. 12, 2023
In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases animals and aiding the exploration mechanisms underlying human diseases. Currently, implantable electrochemical microsensors have emerged as prominent area research. These not only fulfill technical requirements for but also offer an ideal platform integration. They been extensively studied their ability monitor minimally invasive manner, characterized by bloodless, painless features, exceptional performance. The development has witnessed significant scientific technological advancements through dedicated efforts. This review commenced with comprehensive discussion construction microsensors, including materials utilized methods employed fabrication. Following this, we proceeded explore various implantation technologies microsensors. addition, overview was provided applications specifically investigation disease mechanisms. Lastly, concise conclusion conducted on recent obstacles pertaining practical implementation
Язык: Английский
Процитировано
28
Frontiers in Neurology, Год журнала: 2023, Номер 14
Опубликована: Ноя. 16, 2023
Interleukin-17 (IL-17), a cytokine characteristically secreted by T helper 17 (Th17) cells, has attracted increasing attention in recent years because of its importance the pathogenesis many autoimmune or chronic inflammatory diseases. Recent studies have shown that neurological diseases and mental disorders are closely related to immune function, varying degrees dysregulation may disrupt normal expression molecules at critical stages neural development. Starting from relevant mechanisms affecting regulation, this article reviews research progress IL-17 selected group (autism spectrum disorder, Alzheimer’s disease, epilepsy, depression) perspective neuroinflammation microbiota–gut–brain axis, summarizes commonalities, provides prospective outlook target application disease treatment.
Язык: Английский
Процитировано
26
Neurochemistry International, Год журнала: 2024, Номер 177, С. 105761 - 105761
Опубликована: Май 7, 2024
Язык: Английский
Процитировано
17
Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102411 - 102411
Опубликована: Июль 9, 2024
Язык: Английский
Процитировано
16
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июнь 27, 2024
Abstract Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. plays significant role in neuroinflammation, which helps reduce Alzheimer's disease (AD) severity. (Q) quercetin 3-O-glucuronide (Q3OG) are some of the most potent antioxidants available from natural sources. However, form converted into Q3OG when reacted intestinal microbes. The study aims to ensure potential Q Q3OG. In this study, molecular targets were first identified using Swiss Target Prediction platform pathogenic AD DisGeNET database. Followed by compound target overlapping, 77 placed that AKT1, EGFR, MMP9, TNF, PTGS2, MMP2, IGF1R, MCL1, MET PARP1 was top-ranked target, estimated CytoHubba plug-in. Molecular docking performed for towards PDB:1UNQ target. binding score − 6.2 kcal/mol 6.58 respectively. dynamics simulation conducted at 200 ns. This study's results help identify multiple sites bioactive compounds. Thus, synthesizing new chemical entity-based on structural modification may aid eradicating complications.
Язык: Английский
Процитировано
12
Chemical Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review highlights the potential of multi-target-directed strategies that address amyloid-β aggregation, metal ion dyshomeostasis, and enzyme dysfunction, offering a comprehensive effective approach to treating Alzheimer's disease.
Язык: Английский
Процитировано
2