Alzheimer's
disease
(AD)
is
a
debilitating
brain
disorder
with
rapidly
mounting
prevalence
worldwide,
yet
no
proven
AD
cure
has
been
discovered.
Using
multi-omics
approach
in
transgenic
mouse
model,
the
current
study
demonstrated
efficacy
of
modified
Mediterranean-ketogenic
diet
(MkD)
on
AD-related
neurocognitive
pathophysiology
and
underlying
mechanisms
related
to
gut-microbiome-brain
axis.
The
findings
revealed
that
MkD
induces
profound
shifts
gut
microbiome
community
microbial
metabolites.
Most
notably,
promoted
growth
Lactobacillus
population,
resulting
increased
bacteria-derived
lactate
production.
We
discovered
elevated
levels
microbiome-
diet-derived
metabolites
serum
as
well,
signaling
their
influence
brain.
Importantly,
these
changes
upregulated
specific
receptors
have
neuroprotective
effects
induced
alternations
neuroinflammatory-associated
pathway
profiles
hippocampus.
Additionally,
displayed
strong
favorable
co-regulation
relationship
gut-brain
integrity
inflammatory
markers,
well
neurobehavioral
outcomes.
underscore
ameliorative
neurological
function
communication
via
modulation
microbiome-metabolome
arrays.
Nutrients,
Год журнала:
2021,
Номер
13(11), С. 4080 - 4080
Опубликована: Ноя. 15, 2021
Multiple
factors
combined
are
currently
recognized
as
contributors
to
cognitive
decline.
The
main
independent
risk
factor
for
impairment
and
dementia
is
advanced
age
followed
by
other
determinants
such
genetic,
socioeconomic,
environmental
factors,
including
nutrition
physical
activity.
In
the
next
decades,
a
rise
in
cases
expected
due
largely
aging
of
world
population.
There
no
hitherto
effective
pharmaceutical
therapies
treat
age-associated
dementia,
which
underscores
crucial
role
prevention.
A
relationship
among
diet,
activity,
lifestyle
with
function
has
been
intensively
studied
mounting
evidence
supporting
these
development
decline
chief
cause
disability
globally.
Several
dietary
patterns,
foods,
nutrients
have
investigated
this
regard,
some
encouraging
disappointing
results.
This
review
presents
current
effects
components,
supplements,
sleep
social
engagement
on
prevention
or
delay
onset
age-related
dementia.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
Molecular Neurodegeneration,
Год журнала:
2023,
Номер
18(1)
Опубликована: Фев. 1, 2023
Alzheimer's
disease
(AD),
the
most
common
cause
of
dementia,
results
in
a
sustained
decline
cognition.
There
are
currently
few
effective
modifying
therapies
for
AD,
but
insights
into
mechanisms
that
mediate
onset
and
progression
may
lead
to
new,
therapeutic
strategies.
Amyloid
beta
oligomers
plaques,
tau
aggregates,
neuroinflammation
play
critical
role
neurodegeneration
impact
clinical
AD
progression.
The
upstream
modulators
these
pathological
features
have
not
been
fully
clarified,
recent
evidence
indicates
gut
microbiome
(GMB)
an
influence
on
therefore
human
patients.
In
this
review,
we
summarize
studies
identified
alterations
GMB
correlate
with
pathophysiology
patients
mouse
models.
Additionally,
discuss
findings
manipulations
models
potential
GMB-targeted
therapeutics
AD.
Lastly,
diet,
sleep,
exercise
as
modifiers
relationship
between
conclude
future
directions
recommendations
further
topic.
Frontiers in Toxicology,
Год журнала:
2022,
Номер
4
Опубликована: Май 11, 2022
Neurodegeneration
leads
to
the
loss
of
structural
and
functioning
components
neurons
over
time.
Various
studies
have
related
neurodegeneration
a
number
degenerative
disorders.
Neurological
repercussions
can
severe
impacts
on
physical
mental
health
patients.
In
recent
past,
various
neurodegenerative
ailments
such
as
Alzheimer’s
Parkinson’s
illnesses
received
global
consideration
owing
their
occurrence.
Environmental
attributes
been
regarded
main
contributors
neural
dysfunction-related
The
majority
neurological
diseases
are
mainly
prenatal
postnatal
exposure
industrially
produced
environmental
toxins.
Some
neurotoxic
metals,
like
lead
(Pb),
aluminium
(Al),
Mercury
(Hg),
manganese
(Mn),
cadmium
(Cd),
arsenic
(As),
also
pesticides
metal-based
nanoparticles,
implicated
in
disease.
contaminants
known
for
ability
produce
senile
or
amyloid
plaques
neurofibrillary
tangles
(NFTs),
which
key
features
these
dysfunctions.
Besides,
solvent
is
significant
contributor
diseases.
This
study
recapitulates
role
neurotoxins
with
special
emphasis
major
disorders
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(18), С. 10572 - 10572
Опубликована: Сен. 12, 2022
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder;
it
the
most
common
cause
of
dementia
and
has
no
treatment.
It
characterized
by
two
pathological
hallmarks,
extracellular
deposits
amyloid
beta
(Aβ)
intraneuronal
Neurofibrillary
tangles
(NFTs).
Yet,
those
hallmarks
do
not
explain
full
pathology
seen
with
AD,
suggesting
involvement
other
mechanisms.
Neuroinflammation
could
offer
another
explanation
for
progression
disease.
This
review
provides
an
overview
recent
advances
on
role
immune
cells'
microglia
astrocytes
in
neuroinflammation.
In
become
reactive
several
mechanisms
leading
to
release
proinflammatory
cytokines
that
further
neuronal
damage.
We
then
provide
updates
neuroinflammation
diagnostic
markers
investigational
therapeutics
currently
clinical
trials
target
Abstract
High‐fat
diet
(HFD)
has
been
recognized
as
a
primary
factor
in
the
risk
of
chronic
disease.
Obesity,
diabetes,
gastrointestinal
diseases,
neurodegenerative
and
cardiovascular
diseases
have
long
known
with
high
worldwide
incidence.
In
this
review,
influences
gut
microbiota
their
corresponding
bacterial
metabolites
on
mechanisms
HFD‐induced
are
systematically
summarized.
Gut
imbalance
is
also
to
increase
susceptibility
diseases.
Several
studies
proven
that
HFD
negative
impact
microbiota,
exacerbating
course
many
through
increased
populations
Erysipelotrichaceae
,
facultative
anaerobic
bacteria,
opportunistic
pathogens.
Since
bile
acids,
lipopolysaccharide,
short‐chain
fatty
trimethylamine
N
‐oxide
common
features
metabolites,
we
will
explore
possibility
synergistic
among
those
context
Recent
literature
concerning
mechanistic
actions
HFD‐mediated
collected
from
PubMed,
Google
Scholar,
Scopus.
The
aim
review
provide
new
insights
into
point
out
potential
biomarkers
microbiota.
The
advent
of
highthroughput
‘omics’
technologies
has
improved
our
knowledge
gut
microbiome
in
human
health
and
disease,
including
Alzheimer’s
disease
(AD),
a
neurodegenerative
disorder.
Frequent
bidirectional
communications
mutual
regulation
exist
between
the
gastrointestinal
tract
central
nervous
system
through
gut-brain
axis.
A
large
body
research
reported
close
association
microbiota
AD
development,
restoring
healthy
may
curb
or
even
improve
symptoms
progression.
Thus,
modulation
become
novel
paradigm
for
clinical
management
AD,
emerging
effort
focused
on
developing
potential
strategies
preventing
and/or
treating
disease.
In
this
review,
we
provide
an
overview
connection
causal
relationship
dysbiosis
mechanisms
driving
progression,
successes
challenges
implementing
available
microbiome-targeted
therapies
(including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fecal
transplantation)
preventive
therapeutic
preclinical
intervention
studies
AD.
Finally,
discuss
future
directions
field.
