The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6328 - 6328

Опубликована: Март 28, 2023

Neuroinflammation is a critical factor in developing and progressing numerous brain diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation can lead to neurotoxicity, causing damage contributing the onset progression of various Therefore, understanding mechanisms strategies control them crucial for treating Studies have shown that plays vital role such as Alzheimer's (AD) Parkinson's (PD), stroke. Additionally, effects PM

Язык: Английский

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Blood–Brain Barrier Breakdown in Alzheimer’s Disease: Mechanisms and Targeted Strategies

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16288 - 16288

Опубликована: Ноя. 14, 2023

The blood-brain barrier (BBB) is a unique and selective feature of the central nervous system's vasculature. BBB dysfunction has been observed as an early sign Alzheimer's Disease (AD) before onset dementia or neurodegeneration. intricate relationship between pathogenesis AD, especially in context neurovascular coupling overlap pathophysiology neurodegenerative cerebrovascular diseases, underscores urgency to understand BBB's role more deeply. Preserving restoring function emerges potentially promising strategy for mitigating progression severity AD. Molecular genetic changes, such isoform ε4 apolipoprotein E (ApoEε4), significant risk factor promoter dysfunction, have shown mediate disruption. Additionally, receptors transporters like low-density lipoprotein receptor-related protein 1 (LRP1), P-glycoprotein (P-gp), receptor advanced glycation end products (RAGEs) implicated AD's pathogenesis. In this comprehensive review, we endeavor shed light on pathogenic therapeutic connections AD BBB. We also delve into latest developments pioneering strategies targeting interventions, addressing its potential carrier. By providing integrative perspective, anticipate paving way future research treatments focused exploiting therapy.

Язык: Английский

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Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: A review

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114312 - 114312

Опубликована: Май 19, 2023

Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by massive loss of specific neurons. It is a progressive disabling, severe and fatal complex disease. Due to its pathogenesis limitations clinical treatment strategies, it poses serious medical challenge burden worldwide. The AD not clear, potential biological mechanisms include aggregation soluble amyloid form insoluble plaques, abnormal phosphorylation tau protein formation intracellular neurofibrillary tangles (NFT), neuroinflammation, ferroptosis, oxidative stress metal ion disorders. Among them, ferroptosis newly discovered programmed cell death induced iron-dependent lipid peroxidation reactive oxygen species. Recent studies have shown that closely related AD, but the mechanism remains unclear. may be iron metabolism, amino acid metabolism affecting accumulation ions. Some chelating agents (deferoxamine, deferiprone), chloroiodohydroxyquine derivatives, antioxidants (vitamin E, lipoic acid, selenium), derivatives Fer-1, tet, etc. been in animal effective exert neuroprotective effects. This review summarizes regulation natural plant products on order provide reference information for future research development inhibitors.

Язык: Английский

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Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation

Behavioral and Brain Functions, Год журнала: 2025, Номер 21(1)

Опубликована: Янв. 8, 2025

Alzheimer's disease (AD) is a prevalent and progressive neurodegenerative disorder that the leading cause of dementia. The underlying mechanisms AD have not yet been completely explored. Neuroinflammation, an inflammatory response mediated by certain mediators, has exhibited to play crucial role in pathogenesis AD. Additionally, disruption gut microbiota found be associated with AD, fecal transplantation (FMT) emerged as potential therapeutic approach. However, precise mechanism FMT treatment remains elusive. In this study, was performed transplanting from healthy wild-type mice into APP/PS1 (APPswe, PSEN1dE9) assess effectiveness mitigating AD-associated inflammation reveal its action. results demonstrated improved cognitive function reduced expression levels factors regulating TLR4/MyD88/NF-κB signaling pathway mice, which accompanied restoration microbial dysbiosis. These findings suggest ameliorate symptoms delay progression mice.

Язык: Английский

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Stress, depression, and risk of dementia – a cohort study in the total population between 18 and 65 years old in Region Stockholm

Alzheimer s Research & Therapy, Год журнала: 2023, Номер 15(1)

Опубликована: Окт. 2, 2023

Abstract Background Chronic stress and depression are potential risk factors for mild cognitive impairment dementia, including Alzheimer disease. The aim was to investigate whether any such is additive. Methods Cohort study 1 362 548 people (665 997 women, 696 551 men) with records in the Region Stockholm administrative healthcare database (VAL). Exposure a recorded ICD-10 diagnosis of chronic stress, depression, or both, 2012 2013. Outcome disease, other from 2014 through 2022. Odds ratios 99% confidence intervals (CI) adjusted age, sex, neighborhood socioeconomic status, diabetes, cardiovascular disorders were calculated. Results During exposure period, 4 346 patients diagnosed 40 101 898 both. average age at baseline around years all groups. In fully model, odds ratio disease 2.45 (99% CI 1.22–4.91) 2.32 1.85–2.90) 4.00 1.67–9.58) depression. 1.87 1.20–2.91) 2.85 2.53–3.22) 3.87 2.39–6.27) When dementia analyzed, significant only 2.39 1.92–2.96). Conclusions Documented increased same seen novel finding additive effect on MCI AD.

Язык: Английский

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Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Июль 26, 2023

Apigenin is a bioflavonoid compound that widely present in dietary plant foods and possesses biological activities protect against immune, cardiovascular, neurodegenerative diseases cancer. Therefore, apigenin used food medicine, increasing attention has been drawn to developing new delivery systems for apigenin. This review highlights the effects, metabolism, stability, bioactivity of In addition, we summarized advancements apigenin, which provides some references its widespread use medicine. Better stability may enhance digestion absorption provide health benefits. Constructing (such as emulsions, nanostructured lipid carriers, hydrogels, liposomes) an effective strategy improve bioavailability, but more animal cell experiments are needed verify these findings. Developing commercialization still challenging, further research promote their in-depth development utilization.

Язык: Английский

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Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(36), С. 8605 - 8621

Опубликована: Янв. 1, 2023

Alzheimer's disease (AD) is a neurodegenerative that causes memory and cognitive dysfunction reduces person's decision-making reasoning functions. AD the leading cause of dementia in elderly. Patients with have increased expression pro-inflammatory cytokines nervous system, sustained inflammatory response impairs neuronal function. Meanwhile, long-term use anti-inflammatory drugs can reduce incidence to some extent. This confirms anti-neuroinflammation may be an effective treatment for AD. Gold nanoparticles (AuNPs) are emerging nanomaterial promising physicochemical properties, antioxidant. AuNPs neuroinflammation by inducing macrophage polarization toward M2 phenotype, reducing cytokine expression, blocking leukocyte adhesion, decreasing oxidative stress. Therefore, gradually attracting interest scholars used treating diseases drug delivery. Herein, we explored role mechanism The topic worth exploring future, not only help solve global public health problem but also provide reference other neuroinflammatory diseases.

Язык: Английский

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New Pathways Identify Novel Drug Targets for the Prevention and Treatment of Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5383 - 5383

Опубликована: Март 11, 2023

Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disorder. AD a complex and multifactorial that responsible for 60–80% of dementia cases. Aging, genetic factors, epigenetic changes are the main risk factors AD. Two aggregation-prone proteins play decisive role in pathogenesis: β-amyloid (Aβ) hyperphosphorylated tau (pTau). Both them form deposits diffusible toxic aggregates brain. These biomarkers Different hypotheses have tried to explain pathogenesis served as platforms drug research. Experiments demonstrated both Aβ pTau might start processes necessary cognitive decline. The two pathologies act synergy. Inhibition formation has been old target. Recently, successful clearance by monoclonal antibodies raised new hopes treatments if detected at early stages. More recently, novel targets, e.g., improvements amyloid from brain, application small heat shock (Hsps), modulation chronic neuroinflammation different receptor ligands, microglial phagocytosis, increase myelination revealed

Язык: Английский

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Oxidative stress–mediated neuroinflammation in Alzheimer’s disease

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 4, 2024

Язык: Английский

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Extra-Virgin Olive Oil in Alzheimer’s Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1914 - 1914

Опубликована: Фев. 5, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that characterized by several pathological hallmarks, including the deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, blood–brain barrier (BBB) dysfunction, increased oxidative stress, and neuroinflammation. Current treatment options include monoclonal antibody drugs, acetylcholinesterase, n-methyl-d-aspartate (NMDA) antagonists. Although those treatments provide some improvements in patients’ quality life, they fail to prevent or cure AD. research aims identify novel targets tools for AD prevention modification. In this context, studies showed beneficial effect Mediterranean diet One integral component olive oil extra-virgin (EVOO), which high phenolic compounds. EVOO other olive-related compounds have been shown reduce risk developing mild cognitive impairment (MCI) review, we discuss mechanisms exert neuroprotective effects, modulation pathologies promotion health. Findings indicate its constituents influence key processes AD, such as Aβ aggregation, tau phosphorylation, neuroinflammation, while also enhancing BBB integrity reducing stress. The human cited reveal consistent trend where consumption associated with benefits decreased related dementias. conclusion, hold promising potential representing significant shift towards more effective strategies against complex disorder.

Язык: Английский

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