Epigenetic clocks and programmatic aging

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102546 - 102546

Опубликована: Окт. 16, 2024

The last decade has seen remarkable progress in the characterization of methylation clocks that can serve as indicators biological age humans and many other mammalian species. While processes aging underlie these have remained unclear, several clues pointed to a link developmental mechanisms. These include presence vicinity clock CpG sites genes specify development, including those Hox (homeobox) polycomb classes. Here we discuss how recent advances programmatic theories provide framework within which be understood part process aging. This includes such evolve, mechanisms cause aging, they give rise late-life disease. combination ideas from evolutionary biology, biogerontology biology open path new discipline, gerontology (devo-gero). Drawing on properties clocks, offer hypotheses exemplify devo-gero thinking. We suggest controls trade-off between earlier fidelity later plasticity. also propose existence an evolutionarily-conserved sequence spanning ontogenesis, adult development both constrains determines evolution

Язык: Английский

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Biological constraint, evolutionary spandrels and antagonistic pleiotropy

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102527 - 102527

Опубликована: Окт. 5, 2024

Язык: Английский

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Understanding age and society using natural populations

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 379(1916)

Опубликована: Окт. 28, 2024

Ageing affects almost all aspects of life and therefore is an important process across societies, human non-human animal alike. This article introduces new research exploring the complex interplay between individual-level ageing demography, consequences this holds for structure functioning societies various natural populations. We discuss how Special Issue provides a foundation integrating perspectives from evolutionary biology, behavioural ecology demography to provide insights into shapes individuals’ social behaviour associations, in turn impacts networks, processes (such as disease or information transfer) fitness. Through examining these topics taxa, invertebrates birds mammals, we outline contemporary studies are using populations advance our understanding relationship age society innovative ways. highlight key emerging themes Issue, such sociality lifespan health, genetic ecological underpinnings adaptive strategies employed by different species. conclude that underscores importance studying diverse systems interdisciplinary approaches advancing both more generally. part discussion meeting issue ‘Understanding ’.

Язык: Английский

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Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin

Aging, Год журнала: 2025, Номер unknown

Опубликована: Янв. 12, 2025

The untimely passing of Dr. Mikhail "Misha" Blagosklonny has left a lasting void in geroscience and oncology. This review examines his profound contributions, focusing on pioneering the Hyperfunction Theory advocacy for rapamycin, an mTOR inhibitor, as therapeutic agent lifespan extension. Contrary to traditional damage-centric models, rejects damage accumulation primary driver aging. Instead, it redefines aging quasi-programmed process driven by persistent, excessive activity growth-promoting pathways beyond their developmental roles, leading age-related pathologies. We explore how Blagosklonny's insights predict rapamycin's ability decelerate modulating signaling, supported empirical evidence across multiple physiological systems, including immune, cardiovascular, cognitive, oncologic health. His forward-thinking approach, advocating cautious clinical use rapamycin suggesting personalized, preventive, combination therapy strategies, catalyzed interest translational geroscience. synthesizes legacy, presenting foundational pharmacological intervention with potential managing decline extending healthspan, underlines impact shifting research from theoretical frameworks actionable interventions. work remains enduring inspiration, paving way toward treating modifiable condition.

Язык: Английский

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Aging and Dynamics of Information: The Deeper Side of Biology (An Interdisciplinary Commentary)

Advances in Aging Research, Год журнала: 2025, Номер 14(01), С. 22 - 36

Опубликована: Янв. 1, 2025

Язык: Английский

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Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments

Aging Cell, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

ABSTRACT The developmental theory of ageing proposes that age‐specific decline in the force natural selection results suboptimal levels gene expression adulthood, leading to functional senescence. This explicitly predicts optimising adulthood can ameliorate senescence and improve fitness. Reduced insulin/IGF‐1 signalling (rIIS) extends reproductive lifespan Caenorhabditis elegans at cost reduced reproduction. Here, we show adulthood‐only rIIS improves late‐life reproduction without any detrimental effects on other life‐history traits both benign stressful conditions. Remarkably, additively when animals are exposed a fluctuating food environment—intermittent fasting (IF)—resulting intake early adulthood. Full factorial genome‐wide RNA‐Seq across life course demonstrated IF modulate pro‐longevity genes. IF, combined + treatment downregulated genes involved biosynthesis differentially regulated immunity later life. Importantly, uniquely large cluster mid‐life associated with immune response. These suggest decelerate increase

Язык: Английский

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Challenges in Experimental Gerontology: Are Solutions Possible? On the Calculation of Xenobiotic Doses

Ageing & Longevity, Год журнала: 2025, Номер 2. 2025, С. 101 - 110

Опубликована: Фев. 27, 2025

The assessment of resistance to toxic compounds, the capacity biological systems adapt diverse external factors, and specific effects pharmaceutical agents on animals different ages constitute a crucial area research in experimental gerontology. present essay aims analyse endogenous age-dependent structural functional characteristics liver kidneys, which influence metabolism xenobiotics, as well potential methodological errors that may arise addressing this critical issue. study presents evidence indicating pronounced age-related changes relative mass structural-functional properties which, turn, affect organism's response xenobiotic exposure both young old animals. Failure account for these designs inevitably leads erroneous conclusions. To address fundamental issues aging biology, authors propose algorithm consisting four key steps. Implementing studies could facilitate at least partial standardization subjects, enable identification baseline states individual organisms through preliminary longitudinal assessments, allow precise calculation dosages by considering conditions kidneys. suggest such an approach help reduce likelihood findings Keywords: aging, gerontology, methodology science, exposome, metabolism, homeostasis

Язык: Английский

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The Association of Body Temperature with Longevity: Insights from Historical Cohorts

Anthropological Review, Год журнала: 2025, Номер 88(1), С. 61 - 77

Опубликована: Март 28, 2025

Effective thermoregulation is crucial for maintaining homeostasis. Previous research has suggested a link between lower steady-state body temperature and longevity, particularly in physically healthy, nonobese older adults. However, the exact mechanisms behind this relationship remain unclear. Despite physiological insights gained from studies on temperature, limited attention been given to its potential role as biomarker of longevity healthy populations. This study aimed evaluate using historical data two cohorts. The longitudinal cohort consisted 142 individuals, followed 25 years beginning at age 45, while cross-sectional included 204 individuals stratified into four lifespan categories. To examine agerelated trends Page’s test was employed, ordinal regression used. analysis revealed significant decrease women with age, men showed no change. indicated trend toward temperatures longer lifespans. Lower may reflect reduced metabolic rate, thereby mitigating oxidative stress molecular damage, both which are known drive aging limit lifespan. Furthermore, signal favorable inflammatory profile, could translate slower increased survival. observed sex-specific differences thermoregulatory patterns raise important questions about hormonal influences, such estrogen levels. Overall, these findings suggest that lifetime be warranting further exploration mechanistic underpinnings.

Язык: Английский

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Responsible and Sustainable Beauty Consumption for Wellbeing of Older Adults

Journal of Macromarketing, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Research on ageing explains the coping patterns adopted by adults once they face a decline in their physical, financial, and social status with contemplation of life expectancy. In response to changing global trends about longevity, healthy ageing, wellbeing, United Nations (UN) initiated this debate. They referred it as debate 2021–2030 decade ageing. Different from traditional disease-focused research, field has emerged significant area therapeutic inquiry, offering science-based strategies for better management wellbeing. Considering gap highlighted review literature impact era media its consumption beauty subjective personal wellbeing older consumers, research model be tested future researchers is conceptualised. The overarching goal study was influence scientifically responsible sustainable products when offered consumers perspective socially communications.

Язык: Английский

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Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102456 - 102456

Опубликована: Авг. 15, 2024

Understanding mechanisms of ageing remains a complex challenge for biogerontologists, but recent adaptations evolutionary theories offer compelling lens in which to view both age-related molecular and physiological deterioration. Ageing is commonly associated with progressive declines biochemical processes resulting from damage accumulation, yet the role continued developmental gene activation less appreciated. Natural selection pressures are at their highest youthful periods modify expression towards maximising reproductive capacity. After sexual maturation, selective pressure diminishes, subjecting individuals maladaptive pleiotropic functions that were once beneficial growth become pathogenic later life. Due this 'shadowing' ageing, counter such hyper/hypofunctional genes unlikely evolve. Interventions aimed targeting hyper/hypofunction during might, therefore, represent an attractive therapeutic strategy. The nematode Caenorhabditis elegans offers strong model post-reproductive mechanistic investigations, studies examining of, countermeasures against, decline largely intervene larval stages onwards. Importantly, however, lifespan extending conditions frequently impair early-life fitness fail correspondingly increase healthspan. Here, we consolidate multiple discuss data supporting changes global functional level C. elegans, how classical lifespan-extension mutations alter these dynamics. relevance mutant models exploring discussed, highlighting optimisation represents more translatable approach research not constrained by trade-offs. Where some genetic promote late-life health map accordingly healthy humans, other widely used extend worm life-limiting pathologies people. Lifespan has also gold standard quantifying 'ageing', argue gerospan compression (i.e., 'healthier' ageing) appropriate goal anti-ageing research, appear distinct those regulating alone. There is, evident need re-evaluate experimental approaches study elegans.

Язык: Английский

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