Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong DOI Creative Commons
Reena Rajasuriar,

Syaza Fatnin Binti Hisham,

Justin Heejoon Lim

и другие.

Journal of the International AIDS Society, Год журнала: 2024, Номер 28(1)

Опубликована: Дек. 26, 2024

Abstract Introduction WHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age‐associated vulnerabilities. Assessments IC may be useful address evolving, non‐HV care needs ageing people HIV (PWH). However, date, its utility within context has not been assessed. Methods Participants included 200 PWH attending out‐patient (2021−2023) in Universiti Malaya Medical Centre, Malaysia 101 community controls aged 35 years above. The ICOPE framework was adapted derive aggregate scores (ranging 0–6) encompassing five domains cognition, sensory (hearing vision), mobility, mood vitality. Multivariable analyses were used explore association multiple health outcomes including frailty, difficulties performing instrumental activities daily living (IADL) inflammatory markers. Area under receiver operator characteristic (AUC‐ROC) calculated predict frailty IADL deficits current cohort an independent 275 from Hong Kong (HK). Results Median (interquartile range, IQR) age among 50 (42−56) (39−59) years, respectively. There more males (83% vs. 56%, p <0.001). All received antiretroviral therapy (ART) a median duration 11 (8−14) years. Aggregate lower but significantly different compared controls, (5.4 5.6, = 0.093) performed worse than only cognitive domain. independently associated (OR 0.17 95% CI 0.07−0.42, <0.001), 0.25 0.14−0.46, <0.001) all other patient‐reported correlated IL‐6 sCD14 sCD163 levels. well identifying (AUC‐ROC ≥ 0.80) HK Malaysian cohorts modestly 0.64) deficits. Conclusions is good composite non‐HIV, physical social vulnerabilities on ART should complement disease‐based monitoring routine care. validated larger, longitudinal diverse settings.

Язык: Английский

Exercise to Prevent and Manage Frailty and Fragility Fractures DOI Creative Commons
Elsa Dent, Robin M. Daly, Emiel O. Hoogendijk

и другие.

Current Osteoporosis Reports, Год журнала: 2023, Номер 21(2), С. 205 - 215

Опубликована: Март 28, 2023

This review identifies exercise-based recommendations to prevent and manage frailty fragility fractures from current clinical practice guidelines. We also critically assess recently published literature in relation exercise interventions mitigate fractures.

Язык: Английский

Процитировано

35
Frailty: a global health challenge in need of local action DOI Creative Commons
Schenelle Dayna Dlima, Alex Hall, Abodunrin Quadri Aminu

и другие.

BMJ Global Health, Год журнала: 2024, Номер 9(8), С. e015173 - e015173

Опубликована: Авг. 1, 2024

Frailty is a complex, age-related clinical condition that involves multiple contributing factors and raises the risk of adverse outcomes in older people. Given global population ageing trends, growing prevalence incidence frailty pose significant challenges to health social care systems both high-income lower-income countries. In this review, we highlight disproportionate representation research on screening management from countries, despite how countries are projected have larger share people aged ≥60. However, more has been emerging recent years, paving way for context-specific guidelines studies validate assessment tools evaluate interventions population. We then present further considerations contextualising practice First, heterogeneous manifestations call reflects different geographies, populations, systems, community settings policy priorities; can be driven by supportive collaborative between Second, narrative around needs re-evaluation, given negative connotations linked with introduction intrinsic capacity World Health Organization as measure functional reserves throughout life course. Finally, determinants possible majority potential socioeconomic threats national economies warrant proactive these populations.

Язык: Английский

Процитировано

10
Real-life intrinsic capacity screening data from the ICOPE-Care program DOI
Philipe de Souto Barreto, Emmanuel Gonzalez‐Bautista, Heike A. Bischoff‐Ferrari

и другие.

Nature Aging, Год журнала: 2024, Номер 4(9), С. 1279 - 1289

Опубликована: Авг. 9, 2024

Язык: Английский

Процитировано

9
Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults DOI Creative Commons
Reshma Aziz Merchant, Yiong Huak Chan,

Denishkrshna Anbarasan

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Март 6, 2024

Background Decline in intrinsic capacity (IC) has been shown to accelerate progression disability. The study aims explore association of IC composite score with functional ability, sarcopenia and systemic inflammation pre-frail older adults. Methods Cross-sectional adults ≥60 years old recruited from the community primary care centers. Composite scores four domains were measured: locomotion, vitality, cognition psychological. FRAIL scale was used define pre-frailty. Muscle mass measured using bioelectrical impedance analysis. Systemic biomarkers [Interleukin-6 (IL-6), Interleukin-10 (IL-10), Tumor Necrosis Factor Alpha (TNF-α), Growth differentiated factor 15 (GDF-15)] measured. Participants lowest tertile (T1) exhibited greater decline IC. Results A total 398 recruited, mean age 72.7 ± 5.8 years, 60.1% female, education level 7.8 85.2% Chinese ethnicity. 75.1% had 40.5% 53.2% 41.7% psychological domain. 95% at least one T1 significantly associated ADL impairment (aOR 3.36, CI 1.78–6.32), IADL 2.37, 1.36–4.13), poor perceived health 0.96, 0.95–0.98), fall 1.63, 1.05–2.84), cognitive 8.21, 4.69–14.39), depression 101.82, 33.62–308.37), 2.40, 1.60–5.45). significant associations GDF-15, IL-10, IL-10 TNF-α ratio. Conclusion among limitation, sarcopenia, inflammation.

Язык: Английский

Процитировано

6
The assessment and detection rate of intrinsic capacity deficits among older adults: a systematic review and meta-analysis DOI Creative Commons
Fangqin Tan,

Xiaoxia Wei,

Ji Zhang

и другие.

BMC Geriatrics, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 3, 2024

Abstract Background Assessing and monitoring intrinsic capacity (IC) is an effective strategy to promote healthy ageing by intervening early in high-risk populations. This review systematically analyzed the global detection rates of IC deficits explored variations across diverse populations data collection methods. Methods study was preregistered with PROSPERO, CRD42023477315. In this systematic meta-analysis, we searched ten databases from January 2015 October 2023, for peer-reviewed, observational studies or baseline survey trials that assessed among older adults aged 50 above globally following condition, context population approach. The main outcome which could be any tools. Meta-analyses were performed a random-effect model pool subgroup analyses conducted Results Fifty-six 13 countries included 44 meta-analysis. pooled rate 72.0% (65.2%-78.8%) most detected sensory (49.3%), followed locomotion (40.0%), cognition (33.1%), psychology (21.9%), vitality (20.1%). Variations observed studies, higher low- middle-income (74.0%) hyper-aged societies (85.0%). Study measurement tools also explained high heterogeneity studies. Conclusion are common adults, while exists measurement. Early standardized intervention on specific subdomains greatly needed strategies ageing.

Язык: Английский

Процитировано

5
Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach DOI Creative Commons
Kaisa Koivunen, Emiel O. Hoogendijk, L. Schaap

и другие.

Aging Clinical and Experimental Research, Год журнала: 2023, Номер 35(4), С. 815 - 825

Опубликована: Фев. 23, 2023

Intrinsic capacity (IC) defined by the WHO refers to composite of five domains capacities. So far, developing and validating a standardized overall score concept have been challenging partly because its conceptual framework has unclear. We consider that person's IC is determined domain-specific indicators suggesting formative measurement model. To develop an applying approach assess validity. The study sample (n = 1908) consisted 57-88-year-old participants from Longitudinal Aging Study Amsterdam (LASA). used logistic regression models select with 6-year functional decline as outcome. An (range 0-100) was constructed for each participant. examined known-groups' validity comparing groups based on age number chronic diseases. criterion assessed 10-year mortality outcomes. included seven covering all construct. mean 66.7 (SD 10.3). scores were higher among younger those who had lower After adjustment sociodemographic indicators, diseases, BMI, one-point associated 7% decreased risk 2% mortality. developed demonstrated discriminative ability according health status subsequent

Язык: Английский

Процитировано

11
Measurements of Intrinsic Capacity in Older Adults: A Scoping Review and Quality Assessment DOI

Yetian Liang,

Shaomei Shang,

Yaxuan Gao

и другие.

Journal of the American Medical Directors Association, Год журнала: 2022, Номер 24(3), С. 267 - 276.e2

Опубликована: Ноя. 1, 2022

Язык: Английский

Процитировано

16
Intrinsic capacity: an under-researched concept in geriatrics DOI
Emiel O. Hoogendijk, Elsa Dent, Kaisa Koivunen

и другие.

Age and Ageing, Год журнала: 2023, Номер 52(10)

Опубликована: Сен. 8, 2023

In 2015, the World Health Organisation (WHO) introduced concept of intrinsic capacity (IC) as part a new public health model for healthy ageing. IC refers to overall combination an individual's physical and mental capacities, is promoted positive approach wellbeing older adults. However, there still insufficient evidence that implementing leads better care Moreover, current operationalisations lead confusion redundant research. this commentary, we discuss whether has added value geriatrics, describe main issues related its conceptualisation, measurement, application. We argue need clarify validate IC, including independent regarding feasibility acceptance in clinical practice.

Язык: Английский

Процитировано

9
The ICOPE Intrinsic Capacity Screening Tool: Measurement Structure and Predictive Validity of Dependence and Hospitalization DOI Creative Commons
Ángel Rodríguez‐Laso, Francisco J. García‐García, Leocadio Rodríguez‐Mañas

и другие.

The journal of nutrition health & aging, Год журнала: 2023, Номер 27(10), С. 808 - 816

Опубликована: Сен. 1, 2023

To evaluate the measurement structure of ICOPE screening tool (IST) intrinsic capacity and to find out whether IST as a global measure adds explanatory power over above its domains in isolation predict occurrence adverse health outcomes such dependence hospitalization community-dwelling older people. Secondary analysis cohort study, Toledo Study Healthy Ageing. Province Toledo, Spain. Community-dwelling Items equal or similar those were introduced reflective-formative construct Structural Equation Model association with for basic instrumental activities three-year period. A total 1032 individuals analyzed. Mean age was 73.5 years (sd 5.4). The least preserved indicators ability recall three words (18%) perform chair stands (54%). Vision hearing items did not form single sensory domain, so six considered. Several cognition show sufficiently strong univocal associations domain. After pruning ill-behaved items, model fit excellent (Satorra-Bentler scaled chi-square: 10.3, degrees freedom: 11, p=0.501; CFI: 1.000; RMSEA: 0.000, 90% CI: 0.000–0.031, p value RMSEA<=0.05: 1; SRMR: 0.055). In structural model, domain associated expected (p values 0.158 0.293), education 0.190 0.432) 0.654 0.813). included composite individual showed no statistically significant any (dependence activities: 0.162, p=0.167; instrumental: −0.052, p=0.546; hospitalization: 0.145, p=0.167), while only mobility (basic: −0.266, p=0.005; −0.138, p=0.019). last version good 52.1, 52, p=0.469; TLI: 0.01, 0.000–0.02, 0.071). operationalized sum non-impaired after covariate adjustment −0.065, p=0.356; −0.08, p=0.05; −0.003, p=0.949) either. cognitive IST, probably other may need reformulation. does add that constitute it. So far, our results confirm importance checking findings second confirmatory step, described WHO's strategy.

Язык: Английский

Процитировано

8
Investigating resilience through intrinsic capacity networks in older adults DOI Creative Commons
Kaisa Koivunen, Katja Lindeman,

Maija Välimaa

и другие.

The Journals of Gerontology Series A, Год журнала: 2024, Номер 79(10)

Опубликована: Фев. 15, 2024

Abstract Background The network approach may provide a framework for understanding intrinsic capacity (IC) as system’s underlying functioning. resilience to resist functional decline arise from the interrelationships among system components, that is, body functions or capacities. We applied analysis investigate whether interplay between different capacities differs according age and self-rated health (SRH) in older adults. Methods study sample consisted of population-based cohort community-dwelling adults aged 75, 80, 85 years (men n = 356 women 469). quantified 5 IC domains: vitality, locomotion, cognition, psychology, sensory, using performance-based measurements questionnaires, estimated networks 2 (75 vs 80 years) SRH (higher lower) groups separately sexes. Differences global properties (eg, density, overall connectivity) centrality indices were compared groups. Results Intrinsic density (ie, number edges) was higher 80- 85-year-olds 75-year-olds, worse better group both However, differences edge weights strength statistically nonsignificant. Walking speed most central node networks. Conclusions With increasing decline, seems become denser, which indicate loss resilience. is more complex activity than others requiring functioning many subsystems, explain why it connects multiple domains network.

Язык: Английский

Процитировано

2