Ophthalmology Science, Год журнала: 2024, Номер 5(2), С. 100657 - 100657
Опубликована: Ноя. 22, 2024
Язык: Английский
Machine Learning and Knowledge Extraction, Год журнала: 2024, Номер 6(1), С. 464 - 505
Опубликована: Фев. 21, 2024
Alzheimer’s disease (AD) is a pressing global issue, demanding effective diagnostic approaches. This systematic review surveys the recent literature (2018 onwards) to illuminate current landscape of AD detection via deep learning. Focusing on neuroimaging, this study explores single- and multi-modality investigations, delving into biomarkers, features, preprocessing techniques. Various models, including convolutional neural networks (CNNs), recurrent (RNNs), generative are evaluated for their performance. Challenges such as limited datasets training procedures persist. Emphasis placed need differentiate from similar brain patterns, necessitating discriminative feature representations. highlights learning’s potential limitations in detection, underscoring dataset importance. Future directions involve benchmark platform development streamlined comparisons. In conclusion, while learning holds promise accurate refining models methods crucial tackle challenges enhance precision.
Язык: Английский
Процитировано
27
Aging and Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Age-related macular degeneration (AMD) is a progressive neurodegeneration disease that causes photoreceptor demise and vision impairments. In AMD pathogenesis, the primary death of retinal neurons always leads to activation resident microglia. The migration activated microglia ongoing lesion their morphological transformation from branching ameboid-like are recognized as hallmarks pathogenesis. Activated send signals Müller cells promote them react correspondingly damaging stimulus. type neuroglia maintain normal function neurons, modulating innate inflammatory responses, stabilize structure. can accelerate progression by blood vessels. Therefore, crosstalk between plays homeostatic role in maintaining environment, this interaction complicatedly modulated. particular, mechanism mutual regulation two glia populations complex under pathological conditions. This paper reviews recent findings on during pathology process, with special emphasis its therapeutic potentials.
Язык: Английский
Процитировано
12
Aging and Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Age-related macular degeneration (AMD) is a prevalent degenerative disorder of the central retina, which holds global significance as fourth leading cause blindness. The condition characterized by multifaceted pathophysiology that involves aging, oxidative stress, inflammation, vascular dysfunction, and complement activation. complex interplay these factors contributes to initiation progression AMD. Current treatments primarily address choroidal neovascularization (CNV) in neovascular However, approval novel drug therapies for atrophic more gradual variant, known geographic atrophy (GA), has recently occurred. In light substantial impact AMD on affected individuals' quality life strain it places healthcare systems, there pressing need innovative medications. This paper aims provide an updated comprehensive overview advancements our understanding etiopathogenesis Special attention will be given influence aging altered redox status mitochondrial dynamics, cell death pathways, intricate between stress system, specifically context GA. Additionally, this review shed newly approved explore emerging alternative treatment strategies field. objective contribute ongoing dialogue surrounding AMD, offering insights into latest developments may pave way effective management intervention approaches.
Язык: Английский
Процитировано
12
Ageing Research Reviews, Год журнала: 2024, Номер 99, С. 102407 - 102407
Опубликована: Июль 6, 2024
Aging is the greatest risk factor for chronic human diseases, including many eye diseases. Geroscience aims to understand effects of aging process on these genetic, molecular, and cellular mechanisms that underlie increased disease over lifetime. Understanding increases general knowledge physiology impacted by processes at various biological extremes. Two major age-related cataract macular degeneration (AMD) are caused dysfunction lens retina, respectively. Lens transparency light refraction mediated fiber cells lacking nuclei other organelles, which provides a unique opportunity study single hallmark, i.e., loss proteostasis, within an environment limited metabolism. In AMD, local photoreceptors/retinal pigmented epithelium/Bruch's membrane/choriocapillaris complex in macula leads photoreceptors eventually central vision, driven nearly all hallmarks shares features with Alzheimer's disease, Parkinson's cardiovascular diabetes. The can function as model studying basic and, vice versa, well-defined be used tools disease.
Язык: Английский
Процитировано
12
Ageing Research Reviews, Год журнала: 2024, Номер 97, С. 102308 - 102308
Опубликована: Апрель 12, 2024
Язык: Английский
Процитировано
7
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10776 - 10776
Опубликована: Июнь 28, 2023
The retinal pigment epithelium (RPE) performs a range of necessary functions within the neural layers retina and helps ensure vision. regulation pro-oxidative antioxidant processes is basis for maintaining RPE homeostasis preventing degenerative processes. Long-term stable changes in redox balance under influence endogenous or exogenous factors can lead to oxidative stress (OS) development number pathologies associated with dysfunction, eventually vision loss. Reparative autophagy, ubiquitin–proteasome utilization, repair damaged proteins, maintenance their conformational structure are important interrelated mechanisms defense system that protects against damage. Antioxidant protection cells realized as result activity specific transcription factors, large group enzymes, chaperone etc., which form many signaling pathways retina. Here, we discuss role key components (ADS) cellular response OS. Understanding interactions OS mediators ADS contributes formation ideas about subtle prospects experimental approaches restore functions.
Язык: Английский
Процитировано
15
Investigative Ophthalmology & Visual Science, Год журнала: 2023, Номер 64(11), С. 19 - 19
Опубликована: Авг. 14, 2023
This study aimed to investigate the age-dependent anti-angiogenic capability of melatonin in choroidal neovascularization (CNV) and explore underlying molecular mechanisms.In present study, a laser-induced CNV model was established both young (three months age) old (18 mice, size lesions vascular leakage detected by morphological imaging examination. Next, Western blot immunostaining were used observe levels M2 markers, senescence-related molecules involved IL-10/STAT3 pathway. Additionally, colivelin effect pathway activation on expression markers immunostaining. Finally, effects melatonin-induced reduction mice at different ages assessed using examination.Our results revealed that aging promoted macrophage/microglia polarization, aggravated leakage. Melatonin significantly inhibited polarization senescent reduced area Moreover, markedly suppressed STAT3 activator reversed suppressive mice.Our data demonstrated prevented inhibiting pathway, eventually attenuated senescence-associated CNV. These findings suggested could serve as promising therapeutic agent treat other age-related ocular diseases.
Язык: Английский
Процитировано
14
GeroScience, Год журнала: 2023, Номер 46(2), С. 2697 - 2714
Опубликована: Дек. 28, 2023
Язык: Английский
Процитировано
14
Aging Cell, Год журнала: 2023, Номер 22(9)
Опубликована: Июль 26, 2023
Abstract Alterations in the circadian system are characteristic of aging on Earth. With decline physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise elderly populations. Similar risks reported as “red flag” among astronauts during after a long‐term Space exploration journey. However, little is known about common molecular alterations underlying terrestrial space‐related astronauts, controversial conclusions have been recently reported. In light regulatory role clock maintenance human health, we review here overlapping both Earth spaceflight with focus four most affected systems: visual, cardiovascular, central nervous, musculoskeletal systems. this review, briefly introduce specific cellular followed by those aging. We next summarize associated spaceflight, highlighting involved clock‐regulated genes space flown Drosophila , nematodes, small mammals, astronauts. Finally, discuss that altered terms their expression spaceflight. Altogether, data elaborated strengthen our hypothesis regarding timely need include dysregulation an emerging hallmark beyond.
Язык: Английский
Процитировано
13
Ageing Research Reviews, Год журнала: 2023, Номер 93, С. 102142 - 102142
Опубликована: Ноя. 28, 2023
Язык: Английский
Процитировано
12