Emerging Vistas for the Nutraceutical Withania somnifera in Inflammaging

Pharmaceuticals, Год журнала: 2024, Номер 17(5), С. 597 - 597

Опубликована: Май 7, 2024

Inflammaging, a coexistence of inflammation and aging, is persistent, systemic, low-grade seen in the geriatric population. Various natural compounds have been greatly explored for their potential role preventing treating inflammaging. Withania somnifera has used thousands years traditional medicine as nutraceutical its numerous health benefits including regenerative adaptogenic effects. Recent preclinical clinical studies on active inflammation, oxidative stress shown promise use healthy aging. We discuss chemistry somnifera, etiology inflammaging protective role(s) key organ systems brain, lung, kidney, liver well mechanistic underpinning these Furthermore, we elucidate beneficial effects stress/DNA damage, immunomodulation, COVID-19, microbiome. also delineate putative protein–protein interaction network biomarkers modulated by In addition, review safety/potential toxicity global trials somnifera. Taken together, this synthetic highlights improving health-related quality life (HRQoL) aging population worldwide.

Язык: Английский

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Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19

Regenerative Therapy, Год журнала: 2024, Номер 27, С. 319 - 328

Опубликована: Апрель 16, 2024

The severe respiratory effects of the coronavirus disease 2019 (COVID-19) pandemic have necessitated immediate development novel treatments. majority COVID-19-related fatalities are due to acute distress syndrome (ARDS). Consequently, this virus causes massive and aberrant inflammatory conditions, which must be promptly managed. Severe disorders, notably ARDS lung injury (ALI), may treated safely effectively using cell-based treatments, mostly employing mesenchymal stem cells (MSCs). Since high potential these was identified, a great deal research has been conducted on their use in regenerative medicine complementary medicine. Multiple investigations demonstrated that MSCs products, especially exosomes, inhibit inflammation. Exosomes serve critical function intercellular communication by transporting molecular cargo from donor receiver cells. derived exosomes (MSCs/MSC-exosomes) improve permeability, microbial alveolar fluid clearance, epithelial endothelial repair, according recent studies. This review focuses clinical studies involving MSCs/MSC-exosomes. We also investigated utilization Nano-delivery strategies for MSCs/MSC-exosomes anti-inflammatory agents enhance COVID-19 treatment.

Язык: Английский

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Approach to COVID-19 in older adults and indications for improving the outcomes

Annals of Medicine, Год журнала: 2023, Номер 55(2)

Опубликована: Окт. 15, 2023

Background: COVID-19 continues to present challenges in the care of older adults with frailty and/or comorbidities and very old patients, who can be hospitalized severe despite full vaccination. Frailty is a heterogeneous syndrome characterized by an increased aging-related vulnerability due reduced physiological reserve function systemic organs, associated impairment activities daily living. Frail remain at elevated risk mortality from compared without frailty, some pre-existing factors such as malnutrition, prolonged bed rest, association aggravate SARS-CoV-2 infection. Furthermore, severity impact on long-term functioning patients surviving Persistent symptoms are another emerging problem post-vaccination phase pandemic, most suffer chronic which become debilitating affect routine. Aim this review: In complex relationship, evaluation vulnerable categories still matter high interest personalized plans based comprehensive geriatric assessment, tailored interventions; specific therapeutic algorithms among thus recommended order improve outcomes.

Язык: Английский

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Risk factors associated with COVID‐19 pneumonia in Chinese patients with pre‐existing interstitial lung disease during the SARS‐CoV‐2 pandemic

Journal of Medical Virology, Год журнала: 2023, Номер 95(9)

Опубликована: Сен. 1, 2023

Abstract In China, the emergence of a nationally widespread epidemic infection severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) has appeared within month since December 7, 2022. To evaluate risk factors for suffering from disease 2019 (COVID‐19) pneumonia due to with SARS‐CoV‐2 in different kinds interstitial lung (ILD) patients diverse immunizations, we conducted this retrospective study on 525 ILDs who underwent regular follow‐up our ILD clinic. Among them, 128 (24.4%) suffered COVID‐19 after infection. Patients were older male predominance group than nonpneumonia (65.0 ± 10.0 years vs. 56.4 11.7 years, p < 0.001, 55.5% 39.5%, = 0.002, respectively). Connective tissue disease‐associated (CTD‐ILD) (25%), idiopathic pulmonary fibrosis (23.4%), and autoimmune features (21.1%) main pre‐existing group. Cox multivariable analysis, only sex corticosteroid use Two or three doses vaccination protective factor pneumonia. More two strongly recommended patients, particularly males administered corticosteroids.

Язык: Английский

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Senescent T Cells in Age-Related Diseases

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Age-induced alterations in human immunity are often considered deleterious and referred to as immunosenescence. The immune system monitors the number of senescent cells body, while immunosenescence may represent initiation systemic aging. Immune cells, particularly T most impacted involved age-related function deterioration, making older individuals more prone different diseases. T-cell senescence can impact effectiveness immunotherapies that rely on system's function, including vaccines adoptive therapies. research practice using therapeutic targets intervene diseases their nascent stages. Therefore, this review, we summarize recent related literature investigate characteristics well formation mechanisms, relationship with various aging-related diseases, means intervention. primary objective article is explore prospects possibilities therapeutically targeting serving a valuable resource for development immunotherapy treatment

Язык: Английский

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Changes in the innate immune response to SARS-CoV-2 with advancing age in humans

Immunity & Ageing, Год журнала: 2024, Номер 21(1)

Опубликована: Март 21, 2024

Abstract Background Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations mortality. recent COVID-19 pandemic has highlighted this as elderly subjects have emerged vulnerable populations that display increased susceptibility severity SARS-CoV-2. There an urgent need identify the probable mechanisms underlying protect against future outbreaks of such nature. Innate immunity first line defense viruses its decline impacts downstream immune responses. This because dendritic cells (DCs) macrophages key cellular elements innate system can sense respond by producing inflammatory mediators priming CD4 CD8 T-cell Results We investigated changes in responses SARS-CoV-2 function age. Our results using human PBMCs from aged, middle-aged, young indicate activation DCs monocytes response compromised with impairment most apparent pDCs where both aged middle-aged reduced secretion IL-29 confers protection also decreased subjects. In contrast, associated severe including CXCL-8, TREM-1 gene expression data pathways related host dependent decrease concomitant increase pathways. Not only after stimulation but at homeostasis. keeping DC activation, induction cytotoxic T impaired However, baseline accordance enhanced inflammation. Conclusions demonstrate protective anti-viral damaging indicating dysregulated play significant role COVID-19. Furthermore, dysregulation develops early on several these changes. Graphical abstract

Язык: Английский

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Special Issue “Molecular Advances and Perspectives of Lung Disease”

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 946 - 946

Опубликована: Янв. 23, 2025

Respiratory diseases represent a significant global public health challenge, contributing to high mortality and morbidity rates worldwide [...]

Язык: Английский

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Impact of the COVID-19 Pandemic and Vaccination Coverage on the Global Burden of Guillain–Barré Syndrome: A Cross-Sectional Study in 204 Countries and Territories

Опубликована: Янв. 1, 2025

Язык: Английский

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Insights from antiaging-related X discussions: A six-year #Longevity hashtag analysis study

Current Research in Biotechnology, Год журнала: 2025, Номер 9, С. 100280 - 100280

Опубликована: Янв. 1, 2025

Язык: Английский

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Regulatory cytokines modulate early isotype-specific response associated with COVID-19 survival

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 24, 2025

Identifying immune markers driving early and effective antibody response in patients with severe coronavirus disease 2019 (COVID-19) is critical due to the threat of future pandemics, incomplete global vaccination, suboptimal booster coverage. Patients life-threatening acute respiratory syndrome 2 (SARS-CoV-2) infection are characterized by dysregulated thromboinflammation cytokine storm that could influence isotype virus-specific subsequent clinical outcome. We investigated association between COVID-19-related mortality dynamics, magnitude, relative avidity nucleoprotein (N), spike (S), receptor-binding domain (RBD)-specific IgM, IgA, IgG circulation. also assessed relationship responses patterns, as well systemic pulmonary markers. This multicenter study included COVID-19 hospitalized pandemic, classified survivors (n=62) non-survivors (n=17). developed indirect enzyme-linked immunosorbent assays (ELISAs) evaluate each using well-characterized outpatient (n=180) pre-pandemic cohorts (n=111). The pro-inflammatory interleukin (IL)-6 tumor necrosis factor (TNF)-α, regulatory IL-10, transforming growth (TGF)-β1, soluble receptor I (sTNFRI) levels were evaluated. ELISAs performed highly for all isotypes, although modest IgM-N. Non-survivors increased N-specific, but no S-specific, IgM IgA throughout course and, more notably, a delayed class switching IgG-S IgG-RBD compared survivors. No differences observed avidity. Survivors exhibited an proportional degree thromboinflammation, whereas showed those dissociated because their uncontrolled thromboinflammation. Only dominant pattern phase (&lt;10 days after symptoms onset), which strongly correlated developing protective antibodies. easy-to-use enable patient monitoring identify at-risk populations low- middle-income regions. displayed ineffective N-mediated response, marked inability control inflammation compromised time-dependent toward S RBD-specific IgG. axis, including TGF-β1, maybe correlate antibody-mediated immunity COVID-19.

Язык: Английский

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