Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Окт. 13, 2023

Aging is a progressive and irreversible pathophysiological process that manifests as the decline in tissue cellular functions, along with significant increase risk of various aging-related diseases, including metabolic diseases. While advances modern medicine have significantly promoted human health extended lifespan, diseases such obesity type 2 diabetes among older adults pose major challenge to global public societies age. Therefore, understanding complex interaction between factors crucial for promoting well-being healthy aging. This review article explores environmental behavioral associated their impact on The environment, an obesogenic environment exposure toxins, strongly correlated rising prevalence its comorbidities. Behavioral factors, diet, physical activity, smoking, alcohol consumption, sleep patterns, influence throughout Public interventions targeting modifiable can effectively promote healthier lifestyles prevent Collaboration government agencies, healthcare providers community organizations essential implementing these creating supportive environments foster

Язык: Английский

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Physical performance and negative events in very old adults: a longitudinal study examining the ilSIRENTE cohort

Aging Clinical and Experimental Research, Год журнала: 2024, Номер 36(1)

Опубликована: Фев. 12, 2024

Declining physical performance in old age is associated with a wide range of negative health-related outcomes. However, it unclear which capabilities should be prioritized to obtain prognostic information older adults.

Язык: Английский

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The role of myokines in cancer: crosstalk between skeletal muscle and tumor

BMB Reports, Год журнала: 2023, Номер 56(7), С. 365 - 373

Опубликована: Июнь 1, 2023

Loss of skeletal muscle mass is a primary feature sarcopenia and cancer cachexia. In patients, tumor-derived inflammatory factors promote atrophy via tumor-to-muscle effects, which closely associated with poor prognosis. During the past decade, has been considered to function as an autocrine, paracrine, endocrine organ by releasing numerous myokines. The circulating myokines can modulate pathophysiology in other organs, well tumor microenvironment, suggesting muscleto-tumor signaling molecules. Here, we highlight roles tumorigenesis, particularly terms crosstalk between tumor. Better understanding muscle-to-tumor effects will shed light on novel strategies for diagnosis treatment cancer. [BMB Reports 2023; 56(7): 365-373].

Язык: Английский

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New advances of adiponectin in regulating obesity and related metabolic syndromes

Journal of Pharmaceutical Analysis, Год журнала: 2023, Номер 14(5), С. 100913 - 100913

Опубликована: Дек. 13, 2023

Obesity and related metabolic syndromes have been recognized as important disease risks, in which the role of adipokines cannot be ignored. Adiponectin (ADP) is one key with various beneficial effects, including improving glucose lipid metabolism, enhancing insulin sensitivity, reducing oxidative stress inflammation, promoting ceramides degradation, stimulating adipose tissue vascularity. Based on those, it can serve a positive regulator many syndromes, such type 2 diabetes (T2D), cardiovascular diseases, non-alcoholic fatty liver (NAFLD), sarcopenia, neurodegenerative certain cancers. Therefore, promising therapeutic approach for treating diseases may involve elevating ADP levels or activating receptors. The modulation genes, multimerization, secretion covers main processes generation, providing comprehensive orientation development more appropriate strategies. In order to deeper understanding ADP, this paper will provide an all-encompassing review ADP.

Язык: Английский

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Association of Obesity and Bariatric Surgery on Hair Health

Medicina, Год журнала: 2024, Номер 60(2), С. 325 - 325

Опубликована: Фев. 14, 2024

Obesity and obesity-related conditions today constitute a public health problem worldwide. is an "epidemic" chronic disorder, which defined by the WHO as normal or excessive fat accumulation that may impair health. It also for adults BMI greater than equal to 30. The most common diseases are type 2 diabetes mellitus, cardiovascular diseases, metabolic syndrome, kidney disease, hyperlipidemia, hypertension, nonalcoholic fatty liver certain types of cancer. has been proven obesity can have negative effect on hair. lead hair thinning. Patients with undergo bariatric surgery if they meet inclusion criteria. four weight loss include duodenal switch biliopancreatic diversion, laparoscopic adjustable gastric banding, Roux-en-Y bypass, sleeve gastrectomy. Bariatric affect skin associated telogen effluvium due loss, microelement deficiency, anesthesia, low calorie intake, protein intake. who experience post-bariatric depression. Hair major impact self-esteem, negatively affecting one's self-image. purpose this narrative review critically how obesity, in general development cycle, influence loss.

Язык: Английский

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Current knowledge and scientific trends in myokines and exercise research in the context of obesity

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 23, 2024

The relationship between exercise and obesity has attracted increasing attention from researchers worldwide in recent years. aim of the present study was to analyze current knowledge scientific trends research into myokines context provide ideas for future strategies prevent obesity. conducted a comprehensive bibliometric analysis 300 publications related myokines, exercise, 2004 2024. Applying VOSviewer tool, revealed significant increase over time number on these topics, with total 1,142 keywords identified. Key themes identified included molecular processes, new organokines, skeletal muscle research, model organism studies, human studies based sex age differences. highlighted growing interest mechanisms role myokines. Results showed substantial 2014 2024, focus organokines (myokines, adipokines) animal models. underscored importance modulating metabolic processes their potential therapeutic implications managing non-communicable diseases such as Furthermore, close myokine production, regulation metabolism, stress response, inflammation. In conclusion, last years, been focused benefits probably will be set released during contraction. A newly emerged promising marker prevention control

Язык: Английский

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The Effect of Exercise on Spexin and Follistatin in Elderly Individuals

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 1, 2025

ABSTRACT Background In adipose tissue–muscle crosstalk mechanisms, the interaction of adipokines and myokines is known to be critical for maintaining body's metabolic balance in age‐related disorders. The aim study investigate effects 12 weeks aerobic resistance exercise training on spexin follistatin their relationship with each other. Methods This was a multicentre, randomized controlled conducted at two assisted living facilities participants aged ≥ 65. Among 66 subjects, 33 were allocated group (E) control (C). administered 50 min by expert physiotherapists 1 day week weeks. Participants intervention groups performed assignments extra days week, tailored specific circumstances supervised institution's physiotherapists. Spexin, measurements syndrome parameters beginning after Results mean age 62 who completed (E n = 31, C 31) 73.25 ± 6.44 years, 62.9% female. While 1090.94 533.66, 1142.91 550.68 pg/mL, p > 0.05) 50.52 24.35, 50.00 23.52 ng/mL, values similar baseline, 1311.32 513.66, 1033.27 486.48, < 0.0001; η 2 0.387) 64.79 32.35, 48.16 26.27, 0.267) higher than 12. At 12th neck circumference (38.32 3.41, 37.16 3.15, 0.002), waist (102.64 13.38, 98.54 14.47, 0.0001), hip (105.70 15.43, 102.93 13.48, body fat mass (22.69 7.39, 20.45 6.22, 0.0001) systolic diastolic blood pressure (137.19 13.80, 124.9 15.18, 0.0001, 77.38 12.10, 72.61 9.26, 0.043) decreased, muscle (46.32 8.43, 49.03 8.58, increased compared baseline. A correlation observed between change level ( r 0.438, 0.001). negative found amount decrease −0.380, 0.005). positive increase 0.431, 0.001; 0.490, respectively). Conclusions It that spexin, which provides homeostasis, follistatin, expresses mass, implementation 12‐week program elderly individuals, these increases associated Trial Registration ClinicalTrials.gov identifier: NCT05251597

Язык: Английский

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Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management

Metabolites, Год журнала: 2025, Номер 15(2), С. 85 - 85

Опубликована: Фев. 1, 2025

The ‘Body Mass Index’ (BMI) is an anachronistic and outdated ratio that used as internationally accepted diagnostic criterion for obesity, to prioritise, stratify, outcome-assess its management options. On individual level, the BMI has potential mislead, including inaccuracies in cardiovascular risk assessment. Furthermore, places excessive emphasis on a reduction overall body weight (rather than optimised composition) contributes towards misunderstanding of quiddity obesity dispassionate societal perspective response global problem. objective this review provide overview transitions away from novel vista: viewing skeletal muscle (SM). We resurrect SM tissue hidden plain sight key role plays influencing metabolic health efficiency. discuss complex interlinks between adipose (AT) through myokines adipokines, argue rather two separate tissues, AT should be considered single entity: ‘Adipo–Muscle Axis’. vicious circle sarcopenic which aging- obesity-related decline mass worsened status insulin resistance, turn further compounds function. approaches can mitigate against context negative energy balance, optimisation dietary protein intake resistance physical exercises, molecules development target SM, will play important future obesity. Finally, we Adipo–Muscle Ratio (AMR) would more clinically meaningful descriptor definition help shift our focus regarding effective merely inducing loss optimising AMR with proper attention maintenance augmentation

Язык: Английский

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Liraglutide improves senescence and ameliorating diabetic sarcopenia via the YAP-TAZ pathway

Journal of Diabetes and its Complications, Год журнала: 2025, Номер 39(3), С. 108975 - 108975

Опубликована: Фев. 19, 2025

Язык: Английский

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Monocyte CCL2 signaling possibly contributes to increased asthma susceptibility in type 2 diabetes

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 28, 2025

In recent years, the respiratory system has been increasingly recognized as a key target organ in diabetes. Although observational studies have established significant clinical associations between type 2 diabetes (T2D), antidiabetic medication use, and asthma, causal relationships underlying molecular mechanisms remain unclear. This study employed bidirectional two-sample Mendelian randomization (MR) approach combined with bioinformatics analysis to explore T2D asthma subtypes complications, focus on immune-regulatory mechanisms. The MR utilized inverse-variance weighted (IVW) meta-analysis methods evaluate overall effects, sensitivity analyses confirming robustness of findings. Bioinformatics focused differential gene expression pathway enrichment identify potential networks. showed that positive effect (P < 0.05), severe autoimmune showing strong specific (eosinophilic mixed asthma) complications (e.g., acute infections pneumonia) 0.05). identified monocyte-CCL2 signaling axis mechanism linking where hyperglycemia-induced monocyte activation may promote development. These findings reveal shared inflammatory pathways deepen our understanding these two chronic diseases.

Язык: Английский

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