Prognostic impact of cachexia in patients undergoing radical resection for colorectal cancer: a retrospective study DOI Creative Commons

Hideki Tanda,

Masatsune Shibutani, Yuki Seki

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

Abstract Background: Host and tumor factors influence progression. Cachexia has attracted considerable attention as a potential host disease, is multifactorial syndrome characterized by skeletal muscle loss; however, it difficult to objectively assess. The cachexia index (CXI) been reported novel marker for assessing cachexia. This study investigated the relationship between long-term prognosis after colorectal cancer surgery using CXI. Methods: We included 299 patients who underwent radical at Osaka City University Hospital January 2017 December 2019. CXI was originally calculated index, serum albumin level, neutrophil-to-lymphocyte ratio. also evaluated P-CXI, which component of psoas instead follows: (cm2/m2) × level (g/dL) / prognostic value P-CXI univariate multivariate Cox hazard regression models adjusting confounders. Results: low group 185 with significantly shorter relapse-free survival (RFS) overall (OS) than high (p=0.002 p=0.005, respectively). analysis showed significant reduction in RFS OS, wherein following were independent poor factors: age >70 years (hazard ratio [HR]: 2.051, 95% confidence interval [CI]: 1.104–3.807, p=0.022 HR: 2.649, CI: 1.172–5.990, p=0.019, respectively), T4 tumors (HR: 4.153, 1.869–9.233, p<0.001 8.797, 3.185–24.29, p<0.001, preoperative carbohydrate antigen 19-9 >37 U/ml 2.827, 1.224–6.532, p=0.014 5.578, 2.043–15.23, 2.629, 1.312–5.266, p=0.006 2.716, 1.064–6.933, p=0.036, Conclusion: shown have impact resection, where may be useful marker.

Язык: Английский

Exercise training mode effects on myokine expression in healthy adults: A systematic review with meta-analysis DOI Creative Commons
Francesco Bettariga, Dennis R. Taaffe, Daniel A. Galvão

и другие.

Journal of sport and health science/Journal of Sport and Health Science, Год журнала: 2024, Номер 13(6), С. 764 - 779

Опубликована: Апрель 10, 2024

The benefits of exercise are well known; however, many the underlying molecular mechanisms not fully understood. Skeletal muscle secretes myokines, which mediate muscle-organ crosstalk. Myokines regulate satellite-cell proliferation and migration, inflammatory cascade, insulin secretion, angiogenesis, fatty oxidation, cancer suppression. To date, effects different modes (namely, aerobic resistance exercise) on myokine response remain to be elucidated. This is crucial considering clinical implementation enhance general health wellbeing as a medical treatment.

Язык: Английский

Процитировано

14
Age-related and cancer-related sarcopenia: is there a difference? DOI
Federico Bozzetti

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2024, Номер 27(5), С. 410 - 418

Опубликована: Март 15, 2024

The aim of this review is the attempt to differentiating pathophysiologic and clinical features aging-related sarcopenia from cancer-related sarcopenia. In fact, there some controversy among experts mainly regarding two points: always sarcopenia, even that one, expression a generalized disease or may exist independently without major alteration muscle function? Are completely separated entities?

Язык: Английский

Процитировано

5
Skeletal muscle quality predicts overall survival in advanced liver hepatocellular carcinoma treated with SIRT and sorafenib: A subanalysis of the SORAMIC trial DOI Creative Commons
Alexey Surov, Andreas Wienke, Jan Borggrefe

и другие.

United European Gastroenterology Journal, Год журнала: 2024, Номер 12(8), С. 1016 - 1027

Опубликована: Июль 15, 2024

Our purpose was to assess the impact of muscle quality on overall survival (OS) in patients with advanced HCC.

Язык: Английский

Процитировано

5
Secretome from Magnetically Stimulated Muscle Exhibits Anticancer Potency: Novel Preconditioning Methodology Highlighting HTRA1 Action DOI Creative Commons
Yee Kit Tai, Jan Nikolas Iversen,

Karen Ka Wing Chan

и другие.

Cells, Год журнала: 2024, Номер 13(5), С. 460 - 460

Опубликована: Март 5, 2024

Briefly (10 min) exposing C2C12 myotubes to low amplitude (1.5 mT) pulsed electromagnetic fields (PEMFs) generated a conditioned media (pCM) that was capable of mitigating breast cancer cell growth, migration, and invasiveness in vitro, whereas the harvested from unexposed myotubes, representing constitutively released secretome (cCM), less effective. Administering pCM microtumors engrafted onto chorioallantoic membrane chicken eggs reduced tumor volume vascularity. Blood serum collected PEMF-exposed or exercised mice allayed invasiveness. A preconditioning methodology is presented accentuates graded anticancer potencies both cCM demonstrating an adaptive response administered during early myogenesis emulated secretome-based exercise adaptations observed vivo. HTRA1 shown be upregulated demonstrated necessary sufficient for potency pCM; recombinant added basal recapitulated effects antibody-based absorption precluded its effects. Brief non-invasive PEMF stimulation may represent method commandeer muscle, vitro vivo, clinical exploitation other cancers.

Язык: Английский

Процитировано

4
Impact of Changes in Skeletal Muscle Mass Index on Prognosis During Alternating Chemoradiotherapy in Nasopharyngeal Carcinoma DOI

Mariko Ichinose,

Kazuhira Endo,

Nobuyuki Hirai

и другие.

Nutrition and Cancer, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Фев. 18, 2025

Sarcopenia is common in patients with head and neck cancer suggested to be associated decreased survival. This study aimed investigate the relationship between changes skeletal muscle mass during alternating chemoradiotherapy (CRT) prognosis of nasopharyngeal carcinoma (NPC). retrospective included 64 NPC who had undergone CRT at our institution 2005 2022. The index (SMI) was measured using pre- post-treatment computed tomography. SMI 58 (90.6%), a mean change −6.1%. Using cutoff value −6.0% for change, 32 (50.0%) were categorized into loss group. group significantly lower overall survival (OS) than maintenance (122.6 vs. 153.0 months; p = 0.021). Multivariate analysis identified prognostic nutritional (PNI) as independent predictors poor OS (p < 0.05). They used construct nomogram OS. In conclusion, factor. These findings suggest that preserving may improve merits further investigation.

Язык: Английский

Процитировано

0
MEGF6 knockdown ameliorates lenvatinib-induced muscle differentiation suppression and enhances the antitumor effect of lenvatinib on hepatocellular carcinoma DOI
Na Qiang, Junjie Ao, Masato Nakamura

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116829 - 116829

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Prognostic potential of neutrophil-to-lymphocyte ratio for appendicular skeletal muscle mass reduction in males aged 70 and older DOI Creative Commons

Ying‐Jen Chen,

Chieh‐Li Yen, C H Lee

и другие.

Aging, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Inflammation plays a pivotal role in the age-related decline of skeletal muscle mass, leading to sarcopenia elderly. The prevalence notably increases among males aged ≥ 70. However, it remains unclear whether inflammatory indexes are associated with reduction mass elderly population. Thirty-one 70, without severe diseases or dementia, were enrolled study. They underwent measurements, physical and hematological tests at onset study after one-year follow-up. Twenty-eight participants successfully followed for one year. Appendicular index (ASMI) decreased by 3.30 ± 2.41% 14 increased 2.66 1.61% other compared baseline levels. neutrophil-to-lymphocyte ratio (NLR) was 2.14 0.56 ASMI-decreased group 1.66 0.62 ASMI-increased group. A statistically significant negative correlation found between NLR change ASMI linear regression analyses. area under curve (AUC) predicting 0.724, an optimal sensitivity 64.3% specificity 78.6% cut-off value 1.94. emerged as potential prognostic marker males. further studies necessary assess its clinical utility.

Язык: Английский

Процитировано

0
The contribution of the nervous system in the cancer progression DOI Creative Commons
Hongryeol Park, Chan Hee Lee

BMB Reports, Год журнала: 2024, Номер 57(4), С. 167 - 175

Опубликована: Апрель 3, 2024

Cancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME).The TME comprises of diverse cell types, such as cancer cells, immune stromal neuronal cells.These cells mutually influence each other through various including cytokines, vascular perfusion, matrix stiffness.In initial or developmental stage cancer, neurotrophic factors nerve growth factor, brain-derived glial line-derived factor are associated with poor prognosis cancers communicating peripheral nerves TME.Over past decade, research has been conducted to prevent controlling activation tumors, exhibiting a novel attemt in treatment promising results.More recently, focusing on regulation autonomic nervous system, sympathetic parasympathetic systems, gained significant attention.Sympathetic signaling predominantly promotes progression, while role varies among different types.Neurotransmitters released from these signalings can directly indirectly affect TME.Additionally, sensory significantly progression.In advanced cancer-associated cachexia occurs, characterized tissue wasting reduced quality life.This process involves pathways via brainstem differentiation 15-glial receptor alpha-like hypothalamic proopiomelanocortin neurons.Our review highlights critical well central system offering avenues for targeted therapeutic strategies.BMB Rep. www.bmbreports.

Язык: Английский

Процитировано

2
Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review DOI Creative Commons

Amirhossein Ahmadi Hekmatikar,

André R. Nelson, Aaron C. Petersen

и другие.

BMC Cancer, Год журнала: 2023, Номер 23(1)

Опубликована: Сен. 20, 2023

Abstract Background Exerkines are all peptides, metabolites, and nucleic acids released into the bloodstream during after physical exercise. liberated from skeletal muscle (myokines), heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown (batokines), neurons (neurokines) may benefit health wellbeing. Cancer-related cachexia is a highly prevalent disorder characterized by weight loss with specific loss. Many studies have sought to provide exercise strategies for managing cachexia, focusing on musculoskeletal changes. Therefore, understanding responses of other exerkines acute chronic novel insight recommendations training counteract cancer-related cachexia. Methods For purpose conducting this study review, we made efforts gather relevant thoroughly discuss them create comprehensive overview. To achieve this, conducted searches using appropriate keywords in various databases. Studies that were deemed irrelevant current research, not available English, or lacking full-text access excluded. Nevertheless, it important acknowledge limited amount research field. Results In order obtain findings, prioritized human results closely align scope present study. However, instances where additional analysis was required draw more robust conclusions, also incorporated animal studies. Finally, 295 studies, discussed review. Conclusion Our underlying physiological mechanisms related significance investigating cancer currently quite basic. Nonetheless, demonstrated resistance aerobic can contribute reduction control disease individuals as well survivors, inducing changes exerkines.

Язык: Английский

Процитировано

4
Association between Immune Checkpoint Inhibitor Treatment Outcomes and Body Composition Factors in Metastatic Renal Cell Carcinoma Patients DOI Open Access

Kohei Takei,

Toshiki Kijima,

Naoya Ookubo

и другие.

Cancers, Год журнала: 2023, Номер 15(23), С. 5591 - 5591

Опубликована: Ноя. 26, 2023

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of metastatic renal cell carcinoma (mRCC); however, validating body composition-related biomarkers for their efficacy remains incomplete. We evaluated association between markers and prognosis patients with mRCC who received ICI-based first-line therapies.We retrospectively investigated 60 underwent therapy as 2019 2023. Body composition variables, including skeletal muscle, subcutaneous fat, visceral fat indices, were calculated using baseline computed tomography scans. Sarcopenia was defined according to sex-specific cut-off values mass index. The associations indices objective response rate (ORR), disease control (DCR), progression-free survival (PFS), overall (OS) evaluated.Patients sarcopenia had lower ORR DCR than those without (33.3% vs. 61.1%, p = 0.0436 52.4% 94.4%, 0.0024, respectively). Patients a significantly shorter median PFS (14 months not reached, 0.0020) OS (21 0.0023) did. significant predictor (hazard ratio [HR], 4.31; 95% confidence interval [CI], 1.65-14.8; 0.0018) (HR, 5.44; CI, 1.83-23.4; 0.0013) along poor IMDC risk. No found subcutaneous, visceral, total therapeutic effect therapy.Sarcopenia associated rates in therapy.

Язык: Английский

Процитировано

4