The Potential Role of C-Reactive Protein in Metabolic-Dysfunction-Associated Fatty Liver Disease and Aging DOI Creative Commons

Zheng Ding,

Yuqiu Wei,

Jing Peng

и другие.

Biomedicines, Год журнала: 2023, Номер 11(10), С. 2711 - 2711

Опубликована: Окт. 5, 2023

Nonalcoholic fatty liver disease (NAFLD), recently redefined as metabolic-dysfunction-associated (MASLD), is liver-metabolism-associated steatohepatitis caused by nonalcoholic factors. NAFLD/MASLD currently the most prevalent in world, affecting one-fourth of global population, and its prevalence increases with age. Current treatments are limited; one important reason hindering drug development insufficient understanding onset pathogenesis NAFLD/MASLD. C-reactive protein (CRP), a marker inflammation, has been linked to NAFLD aging recent studies. As conserved acute-phase protein, CRP widely characterized for host defense functions, but link between remains unclear. Herein, we discuss available evidence involvement MASLD identify areas where further research needed. We hope this review can provide new insights into aging-associated biomarkers suggest that modulation signaling potential therapeutic target.

Язык: Английский

Cell senescence in liver diseases: pathological mechanism and theranostic opportunity DOI
David Sanfeliu-Redondo, Albert Gibert‐Ramos, Jordi Gracia‐Sancho

и другие.

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2024, Номер 21(7), С. 477 - 492

Опубликована: Март 14, 2024

Язык: Английский

Процитировано

19
Autophagy and the unfolded protein response shape the non-alcoholic fatty liver landscape: decoding the labyrinth DOI
Zahra Dashti, Zeynab Yousefi,

Pouria Kiani

и другие.

Metabolism, Год журнала: 2024, Номер 154, С. 155811 - 155811

Опубликована: Фев. 2, 2024

Язык: Английский

Процитировано

17
Development and validation of machine learning models for MASLD: based on multiple potential screening indicators DOI Creative Commons
Hao Chen, Jingjing Zhang,

Xueqin Chen

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 21, 2025

Background Multifaceted factors play a crucial role in the prevention and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to utilize multifaceted indicators construct MASLD risk prediction machine learning models explore core within these models. Methods were constructed based on seven algorithms using all variables, insulin-related demographic characteristics other indicators, respectively. Subsequently, partial dependence plot(PDP) method SHapley Additive exPlanations (SHAP) utilized explain roles important variables model filter out optimal for constructing model. Results Ranking feature importance Random Forest (RF) eXtreme Gradient Boosting (XGBoost) found that both homeostasis assessment insulin resistance (HOMA-IR) triglyceride glucose-waist circumference (TyG-WC) first second most variables. The with top 10 was superior previous PDP SHAP methods further screen best (including HOMA-IR, TyG-WC, age, aspartate aminotransferase (AST), ethnicity) model, mean area under curve value 0.960. Conclusions HOMA-IR TyG-WC are predicting risk. Ultimately, our AST, ethnicity.

Язык: Английский

Процитировано

2
Natural products in non-alcoholic fatty liver disease (NAFLD): Novel lead discovery for drug development DOI Creative Commons
Lu Wang,

Yonghuan Yan,

Linfang Wu

и другие.

Pharmacological Research, Год журнала: 2023, Номер 196, С. 106925 - 106925

Опубликована: Сен. 13, 2023

With changing lifestyles, non-alcoholic fatty liver disease (NAFLD) has become the most prevalent worldwide. A substantial increase in incidence, mortality, and associated burden of NAFLD-related advanced is expected. Currently, initial diagnosis NAFLD still based on ultrasound there no approved treatment method. Lipid-lowering drugs, vitamin supplementation, lifestyle improvement treatments are commonly used clinical practice. However, lipid-lowering drugs can produce poor patient compliance specific adverse effects. Therefore, exploration bio-diagnostic markers active lead compounds for development innovative urgently needed. More more studies have reported anti-NAFLD effects mechanisms natural products (NPs), which an important source new drug to treat due their high activity low side At present, berberine silymarin been by US FDA enter phase IV studies, demonstrating potential NPs against NAFLD. Studies found that regulation lipid metabolism, insulin resistance, oxidative stress, inflammation-related pathways may play roles process. continuous updating technical means scientific theories, in-depth research targets provide possibilities find drugs. As we know, FXR agonists, PPARα dual CCR2/5 inhibitors gradually coming stage Whether exert regulating these or some unknown remains be further studied. study reviewed targets. Some works discovery docking were also discussed. It hoped this review reference values non-invasive diagnostic clinic.

Язык: Английский

Процитировано

26
Adherence to an antioxidant diet and lifestyle is associated with reduced risk of cardiovascular disease and mortality among adults with nonalcoholic fatty liver disease: evidence from NHANES 1999–2018 DOI Creative Commons
Yingzi Li, Yipin Liu

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Апрель 8, 2024

Background Nonalcoholic fatty liver disease (NAFLD) stands a prevalent chronic condition significantly influenced by oxidative stress. We investigated the unclear relationship between antioxidant-rich diet and lifestyle cardiovascular (CVD) prevalence rate mortality in adult patients with NAFLD. Methods This study utilized data from National Health Nutrition Examination Survey (NHAENS) spanning 1999 to 2018 investigate association adherence an The employed Oxidative Balance Score (OBS) define antioxidant lifestyle. Results Including 8,670 NAFLD, revealed inverse OBS of most CVD conditions. Fully adjusted models demonstrated that each unit increase OBS, overall corresponded 2, 7, 2% reduction all-cause mortality, respectively. In findings Q2 Q3 were linked reduced cancer whereas did not exhibit association. Additionally, Stratified analysis age (<45 years) education level (> high school) CVD. Conclusion These results underscore protective link diminished adults particularly among younger higher-educated populations.

Язык: Английский

Процитировано

10
From MASH to HCC: the role of Gas6/TAM receptors DOI Creative Commons
Daria Apostolo, Luciana Louzada Ferreira,

Federica Vincenzi

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Янв. 17, 2024

Metabolic dysfunction-associated steatohepatitis (MASH) is the replacement term for what used to be called nonalcoholic (NASH). It characterized by inflammation and injury of liver in presence cardiometabolic risk factors may eventually result development hepatocellular carcinoma (HCC), most common form primary cancer. Several pathogenic mechanisms are involved transition from MASH HCC, encompassing metabolic injury, inflammation, immune dysregulation fibrosis. In this context, Gas6 (Growth Arrest-Specific 6) TAM (Tyro3, Axl, MerTK) receptors play important roles. The Gas6/TAM family modulation lipid metabolism, fibrosis, tumor progression metastasis, processes which an role pathophysiology acute chronic diseases. review, we discuss MASH-associated HCC potential involvement system disease progression. addition, since therapeutic strategies limited, also speculate regarding possible future treatments involving targeting or receptors.

Язык: Английский

Процитировано

9
Inflammation, nutrition, and biological aging: The prognostic role of Naples prognostic score in nonalcoholic fatty liver disease outcomes DOI
Yuntao Feng, Wei Xu,

Sijing Tang

и другие.

Diabetes Research and Clinical Practice, Год журнала: 2024, Номер 213, С. 111749 - 111749

Опубликована: Июнь 19, 2024

Язык: Английский

Процитировано

8
Autophagy and Senescence: The Molecular Mechanisms and Implications in Liver Diseases DOI Open Access

Li Qiao,

Yan Lin,

Guangyu Liang

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 16880 - 16880

Опубликована: Ноя. 28, 2023

The liver is the primary organ accountable for complex physiological functions, including lipid metabolism, toxic chemical degradation, bile acid synthesis, and glucose metabolism. Liver function homeostasis essential stability of bodily functions involved in regulation balance between cell proliferation death. Cell proliferation-halting mechanisms, autophagy senescence, are implicated development several diseases, such as cholestasis, viral hepatitis, nonalcoholic fatty disease, fibrosis, hepatocellular carcinoma. Among various death a highly conserved self-degradative cellular process that recycles damaged organelles, debris, proteins. This also provides substrate further A defect machinery can lead to premature accelerated aging, inflammatory state, tumorigenesis, senescence. Senescence, another type, an active player eliminating premalignant cells. At same time, senescent cells affect neighboring by secreting senescence-associated secretory phenotype induce paracrine Autophagy promote delay senescence under different contexts. review decodes roles multiple diseases achieve better understanding regulatory mechanisms implications diseases.

Язык: Английский

Процитировано

18
The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective DOI Creative Commons

Nikolaus Bresgen,

Melanie Kovacs,

Angelika Lahnsteiner

и другие.

Biomolecules, Год журнала: 2023, Номер 13(6), С. 912 - 912

Опубликована: Май 30, 2023

It is widely accepted that nine hallmarks-including mitochondrial dysfunction, epigenetic alterations, and loss of proteostasis-exist describe the cellular aging process. Adding to this, a well-described cell organelle in metabolic context, namely, lipid droplets, also accumulates with increasing age, which can be regarded as further aging-associated Independently their essential role fat stores, droplets are able control integrity by mitigating lipotoxic proteotoxic insults. As we will show this review, numerous longevity interventions (such mTOR inhibition) lead strong accumulation

Язык: Английский

Процитировано

17
Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease DOI

Chaowen Fan,

Anli Ling-Hu,

Dali Sun

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(50), С. 20105 - 20117

Опубликована: Дек. 11, 2023

Nobiletin (NOB), a flavonoid with significant antioxidant potential, holds promise for treating nonalcoholic fatty liver disease (NAFLD). In this work, we aim to assess the effects and investigate molecular mechanisms of NOB on NAFLD. After using methionine choline-deficient diet induce C57BL/6J mice, as well oleic acid HepG2 L02 cells, administered an intervention. The results indicated that significantly ameliorated lipid deposition, oxidative stress, inflammation in NAFLD both models. Its mechanism may involve Nrf2, SREBP-1c, NF-κB signaling pathways. Furthermore, Nrf2 is not only direct target improve damage but also indirectly involved lipid-lowering anti-inflammatory processes By inhibiting found regulatory role metabolism related SREBP-1c closely associated terms inflammation. Our suggest one most critical targets against multiple aspects.

Язык: Английский

Процитировано

16