Unraveling the Complexity of Human Brain: Structure, Function in Healthy and Disease States

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102414 - 102414

Опубликована: Июль 14, 2024

Язык: Английский

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Trends and hotspots in non-motor symptoms of Parkinson’s disease: a 10-year bibliometric analysis

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Янв. 17, 2024

Non-motor symptoms are prevalent among individuals with Parkinson’s disease (PD) and seriously affect patient quality of life, even more so than motor symptoms. In the past decade, an increasing number studies have investigated non-motor in PD. The present study aimed to comprehensively analyze global literature, trends, hotspots research investigating PD through bibliometric methods. Studies addressing Web Science Core Collection (WoSCC), published between January 2013 December 2022, were retrieved. Bibliometric methods, including R package “Bibliometrix,” VOS viewer, CiteSpace software, used investigate visualize parameters, yearly publications, country/region, institution, authors, collate quantify information. Analysis keywords co-cited references explored trends hotspots. There was a significant increase publications PD, total 3,521 articles United States ranked first terms ( n = 763) citations 11,269), maintaining its leadership position all countries. King’s College London (United Kingdom) most active institution 133) K Ray Chaudhuri author 131). Parkinsonism & Related Disorders articles, while Movement cited journal. Reference explosions shown that early diagnosis, biomarkers, novel magnetic resonance imaging techniques, deep brain stimulation become “hotspots” recent years. Keyword clustering revealed alpha-synuclein is largest cluster for keyword heatmap appeared frequently 1,104), followed by life 502), dementia 403), depression 397). Results provide objective, comprehensive, systematic analysis these identifies “hot” developments this field research. This work will inform investigators worldwide help them conduct further develop new therapies.

Язык: Английский

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Optimal dose and type of exercise improve walking velocity in adults with Parkinson’s disease: a systematic review and Bayesian network meta-analysis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 17, 2025

To examine the dose-response relationship between specific types of exercise for improving walking velocity in Parkinson's disease (PD). This systematic review and network meta-analysis included searches PubMed, Medline, Embase, PsycINFO, Cochrane Library, Web Science were searched from inception until February 18th, 2024. Data analysis was performed using R software with MBNMA RJAGS packages. Outcome indicators measured as mean standard deviation (SMD) along 95% confidence intervals (95% CrI). The network's risk bias independently evaluated by two reviewers employing ROB2 tool. Our encompassed 54 studies 2,828 PD patients, examining effects different exercises on velocity. Aerobic Exercise (AE) demonstrated greatest improvement at an optimal dose 1,400 METs-min/week (SMD:1.215, Crl: 0.113 to 2.306). Both Multicomponent (Mul) (SMD: 1.202, 0.193 2.231) Sensory (SE) 0.649, 0.139 1.183) showed outcomes a 1,000 METs-min/week. Resistance Training (RT) most effective 750 (SMD:0.778, 0.062 1.549), while Mind-Body (MBE) yielded significant improvements lower 500 0.580, 0.218 1.137), offering valuable insights prescription management. Various benefits corresponding doses, among which AE speed patients Mets*min/week.Trial registration: PROSPERO (CRD42024506919).

Язык: Английский

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Parkin, a Parkinson's disease-associated protein, mediates the mitophagy that plays a vital role in the pathophysiology of major depressive disorder

Neurochemistry International, Год журнала: 2024, Номер 179, С. 105808 - 105808

Опубликована: Июль 22, 2024

Язык: Английский

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Melatonin alleviates LPS-induced depression-like behavior in mice by inhibiting ferroptosis by regulating RNA methylation-mediated SIRT6/Nrf2/HO-1 pathway

European Journal of Nutrition, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Язык: Английский

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Depression and Parkinson’s disease

Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery), Год журнала: 2024, Номер 8, С. 982 - 991

Опубликована: Авг. 17, 2024

Parkinson's disease is a progressive neurodegenerative with motor symptoms and non-motor impairments, including depression, observed in 2.7-90% of cases. Depression frequently underestimated diagnosed late due to its similarity disease, such as fatigue, sleep disturbances, hypomimia, etc. In approximately 25% patients, depression precedes symptoms, which may indicate connection the pathogenesis disease. The purpose study was analyze current data on pathophysiology, diagnosis, treatment patients results have demonstrated that pathophysiological mechanisms include neurodegeneration dopaminergic, noradrenergic, serotonergic neurons, neuroinflammation, impaired neuroplasticity. For timely treatment, especially those changes or should be regularly examined. Treatment based multimodal approach includes use supportive psychotherapy pharmacotherapy. Alternative methods exercise, cognitive behavioral therapy, transcranial magnetic stimulation, electroconvulsive therapy are also being explored. Thus, requires an individualized approach. Further research into this problem crucial develop improve patient management algorithms.

Язык: Английский

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Exploring Parkinson’s Disease-Associated Depression: Role of Inflammation on the Noradrenergic and Serotonergic Pathways

Brain Sciences, Год журнала: 2024, Номер 14(1), С. 100 - 100

Опубликована: Янв. 20, 2024

Parkinson’s disease (PD) is a multifactorial disease, with genetic and environmental factors contributing to the onset. Classically, PD movement disorder characterized by loss of dopaminergic neurons in nigrostriatal pathway intraneuronal aggregates mainly constituted protein α-synuclein. However, patients also display non-motor symptoms, including depression, which have been linked functional abnormalities non-dopaminergic neurons, serotonergic noradrenergic ones. Thus, through this comprehensive literature review, we shed light on impairment depression PD, focusing putative involvement inflammatory mechanisms.

Язык: Английский

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Effect of Transcranial Direct Current Stimulation (tDCS) on Depression in Parkinson’s Disease—A Narrative Review

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(3), С. 699 - 699

Опубликована: Янв. 25, 2024

Introduction: Depression is the most prevalent comorbid neuropsychiatric condition in individuals with Parkinson’s disease (PD), and its underlying mechanisms are not yet fully understood. Current treatment methods characterised by moderate effectiveness possible side effects, prompting search for new non-invasive safe methods. Methods: This narrative review explores use of transcranial direct current stimulation (tDCS) depression PD, based on neuropsychological measures. Searches were conducted PubMed/Medline, Research Gate, Cochrane databases. Results: Nine relevant studies identified, where scores served as either primary or secondary outcomes. Stimulation protocols displayed heterogeneity, especially concerning choice site. Patient samples also heterogeneous. The majority incorporated anodal targeting left dorsolateral prefrontal cortex (DLPFC). results revealed a reduction among PD patients following tDCS. Potential through which tDCS may alleviate discussed recommendations future research made. Conclusions: Preliminary evidence suggests that applied anodally to DLPFC reduces people PD; however, due heterogeneity analysed, this field should be approached caution warrants further validation confirmation.

Язык: Английский

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New insights into the effects of serotonin on Parkinson's disease and depression through its role in the gastrointestinal tract

Spanish Journal of Psychiatry and Mental Health, Год журнала: 2024, Номер unknown

Опубликована: Июль 1, 2024

Neuropsychiatric and neurodegenerative disorders are frequently associated with gastrointestinal (GI) co-pathologies. Although the central enteric nervous systems (CNS ENS, respectively) have been studied separately, there is increasing interest in factors that may contribute to conditions affecting both systems. There compelling evidence serotonin (5-HT) play an important role several gut–brain disorders. It well known 5-HT essential for development functioning of CNS. However, most body's produced GI tract. A deeper understanding specific effects on provide basis new therapeutic targets. This review summarizes current data focusing ENS motility, particular emphasis novel aspects signaling where CNS comorbidities common, such as Parkinson's disease depressive

Язык: Английский

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Can exercise benefits be harnessed with drugs? A new way to combat neurodegenerative diseases by boosting neurogenesis

Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Июль 25, 2024

Adult hippocampal neurogenesis (AHN) is affected by multiple factors, such as enriched environment, exercise, ageing, and neurodegenerative disorders. Neurodegenerative disorders can impair AHN, leading to progressive neuronal loss cognitive decline. Compelling evidence suggests that individuals engaged in regular exercise exhibit higher production of proteins are essential for AHN memory. Interestingly, specific molecules mediate the effects have shown effectiveness promoting cognition different transgenic animal models. Despite these advancements, precise mechanisms which mimetics induce remain partially understood. Recently, some novel been tested underlying proposed, involving intercommunications between organs muscle-brain crosstalk, liver-brain gut-brain crosstalk. In this review, we will discuss current regarding potential on various neurological Opportunities, challenges, future directions research field also discussed.

Язык: Английский

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