Journal of Alzheimer s Disease, Год журнала: 2024, Номер 98(3), С. 1017 - 1027
Опубликована: Март 14, 2024
Lifestyle factors are linked to differences in brain aging and risk for Alzheimer's disease, underscored by concepts like 'cognitive reserve' 'brain maintenance'. The Resilience Index (RI), a composite of 6 (cognitive reserve, physical cognitive activities, social engagement, diet, mindfulness) provides such holistic measure.
Язык: Английский
Biomedicines, Год журнала: 2024, Номер 12(3), С. 574 - 574
Опубликована: Март 5, 2024
Neurodegeneration poses a significant challenge for the fields of neuroscience and medicine, as it is underlying cause development advancement numerous neurodegenerative psychiatric disorders [...]
Язык: Английский
Процитировано
25
Brain Sciences, Год журнала: 2023, Номер 13(8), С. 1197 - 1197
Опубликована: Авг. 12, 2023
Fear is characterized by distinct behavioral and physiological responses that are essential for the survival of human species. conditioning (FC) serves as a valuable model studying acquisition, extinction, expression fear. The serotonin (5-hydroxytryptamine, 5-HT) system known to play significant role in emotional motivational aspects behavior, including fear learning expression. Accumulating evidence from both animal studies suggests brain regions involved FC, such amygdala, hippocampus, prefrontal cortex, possess high density 5-HT receptors, implicating crucial involvement aversive learning. Additionally, exploring gene polymorphisms have indicated their potential influence on FC. Therefore, objective this work was review existing linking with memory humans. Through comprehensive screening PubMed Web Science databases, 29 relevant were included final review. These investigated relationship between using drug manipulations or 5-HT-related polymorphisms. results suggest elevated levels enhance learning, indicating modulation 5-HT2A receptors regulates Understanding neurochemical messenger associative can provide insights into psychiatric disorders anxiety post-traumatic stress disorder (PTSD), among others.
Язык: Английский
Процитировано
35
Ageing Research Reviews, Год журнала: 2023, Номер 90, С. 102001 - 102001
Опубликована: Июль 5, 2023
Язык: Английский
Процитировано
26
Biomedicines, Год журнала: 2023, Номер 11(5), С. 1464 - 1464
Опубликована: Май 17, 2023
Aging is commonly associated with a decline in motor control and neural plasticity. Tuning cortico–cortical interactions between premotor areas essential for controlling fine manual movements. However, whether plasticity premotor–motor circuits predicts hand abilities young elderly humans remains unclear. Here, we administered transcranial magnetic stimulation (TMS) over the ventral cortex (PMv) primary (M1) using paired-associative (ccPAS) protocol to manipulate strength of PMv-to-M1 connectivity 14 healthy adults. We assessed changes motor-evoked potentials (MEPs) during ccPAS as an index PMv-M1 network tested magnitude MEP might predict interindividual differences performance two tasks that rely on premotor-motor circuits, i.e., nine-hole pegboard test choice reaction task. Results show lower decreased Critically, slope accurately predicted at across age groups, larger slopes (i.e., increase) predicting better baseline both participants. These findings suggest physiological indices could provide neurophysiological marker age-groups.
Язык: Английский
Процитировано
22
Ageing & Longevity, Год журнала: 2025, Номер 1.2025, С. 37 - 45
Опубликована: Фев. 11, 2025
Normal brain ageing is associated with a varying degree of cognitive impairment. One the early hypotheses proposed to explain such changes was “Ca2+ hypothesis ageing”. This review revisits this and uses Ca2+ dependency neuronal excitability as an integrator discuss age-dependent in activity various systems mechanisms that control homeostasis. Amongst these systems, special attention given mitochondrial involvement regulation Ca2+, fact functions induced during process might represent fulcrum between normal, physiological neurodegenerative processes. However, it important understand process, its effects on function, multifactorial, results from high interactions at cellular but also tissular level. Thus, homeostasis are just one element multifactorial fabric underlies ageing. Keywords: central nervous system; ageing, signalling; mitochondria; ageing; neurodegeneration
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 27, 2025
Background For years, diets and natural extracts have been explored for boosting cognition, but limited evidence challenges their recommendation widespread use. Objective Our study aimed to perform a network meta-analysis evaluate effects of on cognitive function in healthy adults. Methods: Researchers reviewed randomized controlled trials from Embase, PubMed, Cochrane Library, Web Science (up 7 September 2024). Study quality was assessed with the Risk Bias Tool, node-splitting analysis ensured consistency (p > 0.05). SUCRA values were calculated using parametric bootstrapping 10,000 resamples. Primary outcomes included global attention, memory, executive function, flexibility, efficacy ranked by probabilities. Results From 27 studies 2,334 samples 19 extract treatments, RPTW showed greatest improvement overall cognition (SUCRA: 95.9%). No significantly outperformed placebo attention. CG (Cistanche + Ginkgo biloba) most effective memory 89.3%), 96.9%), flexibility 98.0%). Conclusion improve adults, while enhances flexibility. Systematic Review Registration https://inplasy.com/inplasy-2024-11-0007 /, identifier INPLASY (INPLASY2024110007).
Язык: Английский
Процитировано
0
Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102356 - 102356
Опубликована: Май 31, 2024
Язык: Английский
Процитировано
4
Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102509 - 102509
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 25, 2025
Язык: Английский
Процитировано
0
Cell Death and Differentiation, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
0