Physical exercise for brain plasticity promotion an overview of the underlying oscillatory mechanism
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Авг. 8, 2024
The
global
recognition
of
the
importance
physical
exercise
(PE)
for
human
health
has
resulted
in
increased
research
on
its
effects
cortical
activity.
Neural
oscillations,
which
are
prominent
features
brain
activity,
serve
as
crucial
indicators
studying
PE
function.
Existing
studies
support
idea
that
modifies
various
types
neural
oscillations.
While
EEG-related
literature
science
exists,
a
comprehensive
review
specifically
healthy
populations
not
yet
been
conducted.
Given
demonstrated
influence
plasticity,
particularly
oscillatory
it
is
imperative
to
consolidate
this
phenomenon.
Therefore,
aims
summarize
numerous
neuromodulatory
mechanisms
over
past
decade,
covering
(1)
resistance
and
aerobic
training
via
oscillations;
(2)
how
mind-body
affects
activity
cognitive
functioning;
(3)
age-Related
neurodegenerative
disease
rehabilitation
oscillation
mechanisms;
(4)
conclusion
future
direction.
In
conclusion,
effect
multifaceted
process,
seeks
comprehensively
examine
existing
studies'
understanding
regulates
brain,
providing
more
scientific
theoretical
foundation
development
personalized
programs
further
research.
Язык: Английский
Research progress on resistance exercise therapy for improving cognitive function in patients with AD and muscle atrophy
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Апрель 8, 2025
Alzheimer's
disease
(AD)
significantly
reduces
the
quality
of
life
patients
and
exacerbates
burden
on
their
families
society.
Resistance
exercise
enhances
overall
cognitive
function
elderly
with
AD
while
positively
improving
memory,
executive
function,
muscle
strength,
reducing
fall
risks,
alleviating
psychological
symptoms.
As
is
a
neurodegenerative
disorder,
some
nerve
factors
are
readily
activated
released
during
exercise.
Therefore,
several
prior
studies
have
concentrated
exploring
molecular
mechanisms
resistance
impact
brain
neural
plasticity.
Recent
investigations
identified
an
intrinsic
relationship
between
individuals
pathological
skeletal
atrophy,
establishing
correlation
level
content.
primarily
targets
muscle,
which
improves
impairment
in
by
vascular
neuroinflammatory
further
restoring
structural
muscle.
Furthermore,
effects
training
vary
among
distinct
subgroups
impairment.
Individuals
exhibiting
lower
demonstrate
more
pronounced
adaptive
responses
physical
performance
over
time.
Consequently,
investigation
warranted
to
determine
whether
tailored
guidelines—such
as
variations
frequency
duration
exercise—should
be
established
for
varying
levels
dementia,
order
optimize
benefits
those
experiencing
This
study
aimed
review
atrophy
cognition,
mechanism
cognition
through
improvement,
optimal
mode
elucidate
additional
advantages
treating
atrophy.
Язык: Английский
Resistance Exercise Training as a New Trend in Alzheimer’s Disease Research: From Molecular Mechanisms to Prevention
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7084 - 7084
Опубликована: Июнь 27, 2024
Alzheimer's
disease
is
a
pathology
characterized
by
the
progressive
loss
of
neuronal
connections,
which
leads
to
gray
matter
atrophy
in
brain.
most
prevalent
type
dementia
and
has
been
classified
into
two
types,
early
onset,
associated
with
genetic
factors,
late
environmental
factors.
One
greatest
challenges
regarding
high
economic
cost
involved,
why
number
studies
aimed
at
prevention
treatment
have
increased.
possible
approach
use
resistance
exercise
training,
given
that
it
shown
neuroprotective
effects
disease,
such
as
increasing
cortical
hippocampal
volume,
improving
neuroplasticity,
promoting
cognitive
function
throughout
life
cycle.
However,
how
training
specifically
prevents
or
ameliorates
not
fully
characterized.
Therefore,
aim
this
review
was
identify
molecular
basis
could
prevent
treat
disease.
Язык: Английский
The Potential Related Genes and Mechanisms Involved in Improving the Treadmill Exercise Ability of APP/PS1 Mice
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10244 - 10244
Опубликована: Сен. 24, 2024
Alzheimer’s
disease
(AD)
causes
a
decline
in
skeletal
muscle
function,
which
can
further
exacerbate
the
cognitive
dysfunction
of
patients
with
AD.
It
has
been
widely
established
that
exercise
improves
AD
brain
pathology,
but
role
is
still
poorly
understood.
In
this
study,
we
investigated
effects
treadmill
on
ability
APP/PS1
transgenic
mice
and
explored
potential
gene
expression
changes
their
muscle.
The
were
subjected
to
for
12
weeks,
followed
by
Morris
water
maze
open
field
test.
After
behavioral
experiments,
morphology,
area,
collagen
fiber
deposition,
ultrastructure
determined;
balance
protein
synthesis
decomposition
was
analyzed;
using
RNA-Seq.
We
found
strategy
promote
learning
memory
abilities
mice,
reduce
anxiety-like
behavior,
improve
ability,
alleviate
atrophy,
optimize
microstructure.
also
enhance
several
signaling
pathways,
such
as
JAK–STAT,
Wnt,
NOD-like
receptors
while
decreasing
calcium,
cAMP,
cGMP–PKG,
other
pathways.
Six
KEGG
enrichment
pathways
downregulated
five
upregulated
compared
wild-type
these
precisely
reversed
after
exercise.
transcription
factors
Fosb
Egr1
decreased,
decrease
regulated
target
genes
Socs1,
Srrm4,
Il1b,
trend
following
intervention.
exercise,
exhibited
similar
indicating
enhanced
ability.
regulatory
related
identified
study
provide
valuable
insights
clinical
management
treatment
Язык: Английский