International Journal of Cosmetic Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
The
hair
shaft
is
often
exposed
to
shampoo
and
haircare
products
that
have
unknown
or
varying
pH
levels.
These
contain
a
combination
of
surfactants
other
active
ingredients
treat
the
scalp.
As
amphoteric
proteins,
keratins
limited
buffering
capacity,
so
variations
in
can
multifaceted
impacts
on
them.
However,
there
knowledge
about
how
affects
keratin-associated
proteins
(KAPs).
Therefore,
this
study
aims
examine
effects
levels
(pH
3-pH
12)
structure
analyse
consequent
alterations
proteome
using
mass
spectrometry-based
proteomics.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 21, 2025
Hair
follicles
are
essential
appendages
of
human
skin
that
function
in
protection,
sensation,
thermoregulation
and
social
interactions.
The
multicellular
components,
particularly
the
dermal
papilla,
matrix
bulge
housing
stem
cells,
enable
cyclic
hair
growth
postnatally.
However,
miniaturization
loss
can
occur
context
ageing,
trauma
various
alopecia-related
diseases.
Conventional
treatments
involve
redistribution
existing
follicles,
which
may
not
be
viable
patients
lacking
follicular
resources.
Recent
progress
comprehension
morphogenesis
development
biomaterials
has
significantly
advanced
follicle
reconstruction,
incorporating
organ
germ
assembling,
cell
induction
bioprinting
techniques.
Despite
these
advancements,
fully
restoring
remains
challenging
due
to
complexities
replicating
embryonic
signals
sustaining
cycles.
Identifying
suitable
sources
for
clinical
applications
also
presents
a
hurdle.
Here,
we
retrospect
made
field
regeneration,
aiming
offer
an
exhaustive
analysis
on
benefits
limitations
methods,
foster
innovative
solutions.
GeroScience,
Год журнала:
2024,
Номер
46(3), С. 3105 - 3122
Опубликована: Янв. 6, 2024
Abstract
Hair
graying,
also
known
as
canities
or
achromotrichia,
is
a
natural
phenomenon
associated
with
aging
and
influenced
by
external
factors
such
stress,
environmental
toxicants,
radiation
exposure.
Understanding
the
mechanisms
underlying
hair
graying
an
ideal
approach
for
developing
interventions
to
prevent
reverse
age-related
changes
in
regenerative
tissues.
induced
ionizing
(γ-rays
X-rays)
has
emerged
valuable
experimental
model
investigate
molecular
pathways
involved
this
process.
In
review,
we
examine
existing
evidence
on
radiation-induced
particular
focus
potential
role
of
cellular
senescence.
We
explore
current
understanding
aging,
delve
into
mechanisms,
highlight
unique
advantages
using
ionizing-irradiation–induced
research
model.
By
elucidating
involved,
aim
deepen
our
potentially
identify
novel
therapeutic
targets
address
phenotypic
change.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 4, 2025
Hair
loss
has
long
been
a
significant
concern
for
many
individuals.
Recent
studies
have
indicated
that
mitochondria
play
more
crucial
role
in
hair
than
previously
recognized.
This
review
summarizes
the
connection
between
mitochondrial
dysfunction
and
follicle
development,
outlines
links
diseases
related
to
disorders
issues,
highlights
influence
of
on
androgenetic
alopecia.
We
discuss
cellular
signaling
mechanisms
associated
with
examine
how
dysfunction,
such
as
insufficient
energy
supply,
irregularities,
protein/gene
abnormalities,
programmed
cell
death,
can
hinder
normal
proliferation,
differentiation,
growth
cells.
Furthermore,
we
current
treatment
approaches
potential
innovative
therapies,
including
mitochondrion-targeting
drugs
advanced
techniques
directly
target
cells,
providing
fresh
insights
into
maintaining
health
managing
disorders.
this
explores
future
therapeutic
strategies
proposes
research
could
lead
groundbreaking
treatments
loss,
thus
optimism
new
avenues
individuals
experiencing
loss.
not
only
underscores
central
importance
but
also
emphasizes
advancing
field.
ABSTRACT
The
insulin‐like
growth
factor‐1
(IGF‐1)
signaling
pathway
is
known
as
a
potent
aging
modifier,
disruption
of
which
consistently
associates
with
lifespan
extension
across
diverse
species.
Despite
this
established
association,
the
mechanisms
by
IGF‐1
modulates
organ
remain
poorly
understood.
In
study,
we
assessed
age‐related
changes
in
expression
multiple
organs
mice
and
identified
more
prominent
increase
skin
levels
aging—a
phenomenon
also
observed
human
skin.
To
explore
consequences
elevated
IGF‐1,
developed
transgenic
ectopically
expressing
epidermis,
driven
bovine
keratin
5
promoter
(IGF‐1
Tg).
These
exhibited
premature
hair
follicles,
evidenced
accelerated
graying
loss.
Single‐cell
RNA
sequencing
analyses
dorsal
highlighted
an
upsurge
cellular
senescence
markers
senescence‐associated
secretory
phenotype
(SASP)
follicle
stem
cells
(HFSCs),
alongside
decline
HFSC
exhaustion.
Our
findings
indicate
that
excessive
triggers
senescence,
thereby
disrupting
homeostasis.
Remarkably,
interventions
via
downstream
mechanisms—specifically
blocking
Ac‐p53
activation
SIRT1
overexpression
or
senolytic
treatment
for
senescent
cell
clearance,
reducing
through
dietary
restriction—significantly
reduced
markers,
mitigated
phenotypes,
restored
pool.
provide
fundamental
insights
into
biological
processes
highlight
therapeutic
promise
targeted
to
rejuvenate
aged
HFSCs
promote
health.
Skin Research and Technology,
Год журнала:
2024,
Номер
30(4)
Опубликована: Март 28, 2024
Hair
and
scalp
disorders
present
a
significant
challenge
in
dermatology
due
to
their
clinical
diversity
overlapping
symptoms,
often
leading
misdiagnoses.
Traditional
diagnostic
methods
rely
heavily
on
expertise
are
limited
by
subjectivity
accessibility,
necessitating
more
advanced
accessible
tools.
Artificial
intelligence
(AI)
deep
learning
offer
promising
solution
for
accurate
efficient
diagnosis.
