Association between different skeletal muscle mass indices, physical function, and inflammation in obese pre-frail older adults

Archives of Gerontology and Geriatrics, Год журнала: 2023, Номер 118, С. 105289 - 105289

Опубликована: Ноя. 26, 2023

Язык: Английский

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Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Дек. 19, 2023

Background Aging is a significant risk factor for many neurodegenerative diseases and neurological tumors. Previous studies indicate that the frailty index, facial aging, telomere length (TL), epigenetic aging clock acceleration are commonly used biological proxy indicators. This study aims to comprehensively explore potential relationships between tumors by integrating various indicators, employing Mendelian randomization (MR) analysis. Methods Two-sample bidirectional MR analyses were conducted using genome-wide association (GWAS) data. Summary statistics tumors, along with obtained from extensive meta-analyses of GWAS. Genetic single-nucleotide polymorphisms (SNPs) associated exposures as instrumental variables, assessing causal three (Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis), two benign (vestibular schwannoma meningioma), one malignant tumor (glioma), four indicators (frailty TL, acceleration). Sensitivity also performed. Results Our analysis revealed genetically predicted longer TL reduces Alzheimer’s disease but increases vestibular glioma (All Glioma, GBM, non-GBM). In addition, there suggestive relationship some (PD GBM) DNA methylation GrimAge acceleration. Causal other not observed. Conclusion Building upon prior investigations into telomeres our validates these findings larger GWAS data demonstrates, first time, GBM may promote age research provides new insights evidence

Язык: Английский

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Impact of Gut Microbiota on Aging and Frailty: A Narrative Review of the Literature

Geriatrics, Год журнала: 2024, Номер 9(5), С. 110 - 110

Опубликована: Авг. 31, 2024

Aging is a natural, complex, and individual process that focuses on the progressive decay of body decrease in cell function begins approximately sixth decade life ends with death. Current scientific evidence shows aging mostly related to genetic load varies because environment. Therefore, can be adjusted through intervention factors control homeostasis genetic, biochemical, immunological processes, including those involving gut microbiota. Indeed, diversity microbiota decreases during aging, based presence modifications hormonal, immunological, operational processes gastrointestinal tract. These lead state dysbiosis. However, altering bacterial communities remains complicated due great influence their modification. Alterations caused by are known foster dysbiosis correspond conditions determine degree frailty senior citizens. Consequently, microbial structure used as biomarker for geriatric care promotion healthy aging.

Язык: Английский

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Heterogeneity and Differentiation of the Human Arterial Tree: Focus on microRNA Expression in Vascular Disease

Biomolecules, Год журнала: 2024, Номер 14(3), С. 343 - 343

Опубликована: Март 12, 2024

Human arteries show structural and functional peculiarities according to the nutrient oxygen needs of a specific vascular district. This architectural heterogeneity is reflected in pathological setting cardiovascular diseases (CVDs). Indeed, responsiveness risk factors, morphological molecular patterns are discriminating factors among CVDs affecting different beds. MicroRNAs (miRNAs) endogenous regulators gene expression fine-tuners cell differentiation; thus, these non-coding RNAs can modulate arterial heterogeneity. The identification an artery-specific miRNA signature would be promising therapy CVDs, especially patients who frail elderly. In present review, we will provide concise description tree on cellular basis, mainly context. Secondly, address potential as crucial mediators heterogeneity, focusing abdominal aorta femoral artery, with final goal strengthening search for more targeted therapies stratification approaches

Язык: Английский

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Elevated circulating procathepsin L as a potential biomarker of inflamm-aging

Medical Hypotheses, Год журнала: 2024, Номер 186, С. 111322 - 111322

Опубликована: Март 14, 2024

Inflamm-aging is a condition of low-grade and chronic systemic inflammation characterized by increase in multiple inflammatory biomarkers such as tumor necrosis factor (TNF), interleukin 6 (IL-6), C-reactive protein (CRP), CXCL9 (MIG) experimental clinical settings. However, despite the recent identification extracellular procathepsin L (pCTS-L) novel mediator diseases sepsis, its possible role inflamm-aging was previously not investigated. In present study, we compared blood levels pCTS-L other 62 cytokines chemokines between young aged Balb/C mice Western blotting Cytokine Antibody Arrays. light surprising finding marked mice, propose that may serve another biomarker inflamm-aging. Given capacity inducing various (e.g., TNF IL-6), it will be important to test hypothetic under conditions.

Язык: Английский

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Invariances in relations between aging, exposure to external hazards, and mortality reflected in life table aging rate (LAR) patterns examined through the lens of generalized Gompertz–Makeham law

Biogerontology, Год журнала: 2024, Номер 25(6), С. 1079 - 1096

Опубликована: Июль 22, 2024

Язык: Английский

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Wound healing: insights into autoimmunity, ageing, and cancer ecosystems through inflammation and IL-6 modulation

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 29, 2024

Wound healing represents a complex and evolutionarily conserved process across vertebrates, encompassing series of life-rescuing events. The runs in three main phases: inflammation, proliferation, maturation/remodelling. While acute inflammation is indispensable for cleansing the wound, removing infection, eliminating dead tissue characterised by prevalence neutrophils, proliferation phase transition into inflammatory cell profile, shifting towards macrophages. involves development granulation tissue, comprising fibroblasts, activated myofibroblasts, endothelial cells. Communication among these cellular components occurs through intercellular contacts, extracellular matrix secretion, as well paracrine production bioactive factors proteolytic enzymes. intricately regulated particularly interleukin-6. Prolonged results dysregulations during formation may lead to chronic wounds or hypertrophic/keloid scars. Notably, pathological processes such autoimmune organ fibrosis, tumour microenvironment, impaired repair following viral infections notably share morphological functional similarities with tissue. Consequently, wound emerges prototype understanding diverse processes. prospect gaining comprehensive holds potential furnish fundamental insights modulation intricate dialogue between cancer cells non-cancer within ecosystem. This knowledge pave way innovative approaches diagnostics, disease monitoring, anticancer therapy.

Язык: Английский

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Exceeding the Limits with Nutraceuticals: Looking Towards Parkinson’s Disease and Frailty

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 122 - 122

Опубликована: Дек. 26, 2024

One of the most pressing challenges facing society today is rising prevalence physical and cognitive frailty. This geriatric condition makes older adults more vulnerable to disability, illness, a heightened risk mortality. In this scenario, Parkinson’s disease (PD) frailty, which share several common characteristics, are becoming increasingly prevalent worldwide, underscoring urgent need for innovative strategies. Nutraceuticals naturally occurring bioactive compounds contained in foods, offering health benefits over above essential nutrition. By examining literature from past decade, review highlights how nutraceuticals can act as complementary therapies, addressing key processes, such oxidative stress, inflammation, neuroprotection. Notably, antioxidant action appears particularly beneficial regard PD For instance, antioxidant-rich may mitigate damage linked levodopa therapy PD, potentially reducing side effects enhancing treatment sustainability. Similarly, amplify activity, muscle function, health, resilience, thereby proposes holistic approach integrating with exercise, pharmacotherapy, lifestyle adjustments. It promises transform management ARD, prolong life, improve quality life well-being people.

Язык: Английский

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Invariances in relations between the rates of mortality and aging captured by a generalization of the Gompertz-Makeham law: Lessons from Caucasus

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 12, 2024

Abstract Among scarce biological relations qualifiable as laws, the Gompertz-Makeham law (GML) stands out being directly related to life-and-death issues. GML may be written as: -[d n ( t )/ )]/d ≡ µ ) = e^(- v + γt C )*e^( gt 0 *e^( , where is mortality rate (MR), captures vitality (resistance mortality), g aging-associated decrease, 1/e^ initial MR, and MR part attributable external (background) hazards irresistible at any age. status questionable since, upon common assumptions that decreases linearly constant, MR-vs-age trajectories violate GML, especially later ages. A generalized (GGML) )+ *e^[ f )] suggests increases exponentially IF linearly, i.e. 0. GGML produces changes from by exponentiation and, background hazardousness changes, in a linear way. Thus, deduced ), provided treated properly. Based on this, it shown hump of aging revealed through lens ages 65 90 years low countries featuring high life expectancies discerned also taking into account there increased mostly middle age span, North Caucasus some other Russian Federation regions. relational invariants inherent animate nature discernable even beneath such multifactorial phenomena human its diverse manifestations kinetics. These constrain advances expectancy.

Язык: Английский

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The Association between Circulating Cytokines and Body Composition in Frail Patients with Cardiovascular Disease

Nutrients, Год журнала: 2024, Номер 16(8), С. 1227 - 1227

Опубликована: Апрель 20, 2024

The burden of cardiovascular disease and the percentage frail patients in aging population will increase. This study aims to assess circulating levels several cytokines patients. is an ancillary analysis FRAPICA trial. ratio men/women changed from robust through groups 3:1 1:2. are comparable terms age body measurements (weight, height, BMI), yet have significantly reduced fat-free mass, more often been diagnosed with diabetes. Frail higher fibroblast growth factor basic (FGF basic) follistatin (borderline significance). In multiple linear regression modeling we identified FGF basic, osteopontin, stem cell factor, soluble suppression tumorigenicity 2, epidermal receptor, human receptor follistatin, prolactin, interleukin 6 alfa, platelet endothelial adhesion molecule 1, vascular leptin, angiopoietin/tyrosine kinase granulocyte colony-stimulating factor. We a few that correlate hallmark frailty. They comprise kinins implicated bone muscle metabolism, fibrosis, wall function, inflammation, endocrine or regulation marrow integrity.

Язык: Английский

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