Trend in prevalence, associated risk factors, and longitudinal outcomes of sarcopenia in China: A national cohort study

Journal of Internal Medicine, Год журнала: 2024, Номер 296(2), С. 156 - 167

Опубликована: Май 27, 2024

Abstract Aims To estimate the contemporary trend in prevalence of sarcopenia and evaluate its risk factors longitudinal associations with multiple chronic conditions mortality among Chinese middle‐aged older adults. Methods This was a nationwide, prospective cohort study using data from China Health Retirement Longitudinal Study. The definition based on Asian Working Group for Sarcopenia 2019 algorithm. In cross‐sectional analysis, we estimated weighted 2011 to 2015 examined associated severity 2011. assessed between 14 during 9‐year follow‐up. Results remained consistently high overall population (15.9%, 95% confidence intervals [CI]: 15.1, 16.6) (15.0%, CI: 14.3, 15.6; p = 0.075). A range were independently sarcopenia, including age, female sex, lower socioeconomic status, smoking malnutrition, several conditions. Possible sarcopenic individuals had higher odds (i.e., heart disease, lung memory‐related disease) increased risks (possible sarcopenia: ratios (OR): 1.66, 1.37, 2.00; OR: 1.69, 1.36, 2.11) 9 years Conclusions investigated population. Various significantly sarcopenia. Sarcopenic mortality, highlighting that urgent need dedicated efforts improve management patients.

Язык: Английский

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Using CT imaging to identify sarcopenia as a risk factor for severe falls in older adults

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 1, 2025

Abstract Background Sarcopenia is a skeletal muscle disease primarily associated with ageing and progressive decline increases the risk of falls. The purpose present study was to investigate factors, including sarcopenia, for severe falls compared non-severe In addition, we wanted explore possible associations between bone mineral density (BMD), adipose tissue as well clinical scores assessing frailty, nutritional status, fall risk. Methods This retrospective cohort included 101 older patients that had experienced incident during in-patient care at geriatric ward 2018 2020. incidents were categorized into or Clinical data, assessment retrospectively obtained from participants’ medical records. Body composition, quantity (SKM), tissues, BMD assessed abdominal CT-scans performed any reason maximal 6 months before after fall. Skeletal index ratio (SMI-ratio) calculated using SKM cm 2 /height m divided previous described cut off values sarcopenia. An SMI < 100% indicated Results group showed higher grade sarcopenia (SMI 71% vs. 83%, p = 0.041) lower, though statistically non-significant, BMI subcutaneous (SAT) (BMI 22 [20–24] 24 [22–27] kg/m , 0.108, SAT 95 ± 70 cm² 141 94 cm², 0.124). Overweight more common in than (43% 14%, 0.048). correlated negatively frailty positive following body composition measurements: intramuscular-, subcutaneous, visceral (IMAT, VAT). No correlation other nor spine T-score found. multivariate analysis, level male sex lower BMI, VAT remained factors low ratio. Conclusions These results underscore importance addressing related malnutrition, management prevention elderly population. analyzed could add value this assessment. analysis be conducted opportunistically CT scans purposes.

Язык: Английский

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Nutrition in the prevention and treatment of skeletal muscle ageing and sarcopenia: a single nutrient, a whole food, and a whole diet approach

Proceedings of The Nutrition Society, Год журнала: 2024, Номер unknown, С. 1 - 16

Опубликована: Окт. 17, 2024

Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults associated with an increased risk disability, frailty premature death. Finding cost-effective prevention treatment strategies for sarcopenia the growing ageing population therefore great public health interest. Although nutrition considered important factor aetiology sarcopenia, its potential and/or still being evaluated. Nutrition research utilises three main approaches to understand muscle-nutrition relationships, evaluating: single nutrients, whole foods diet effects - both alone or combined exercise. Applying these approaches, we summarise recent evidence from qualitative quantitative syntheses findings observational intervention studies healthy adults, those sarcopenia. We consider protein supplements, (fruits vegetables) Mediterranean as exemplars. There some beneficial supplementation ≥ 0·8 g/kg body weight/d on when exercise training sarcopenic adults. In contrast, function (strength physical performance) inconclusive. reasonably consistent epidemiological suggesting benefits higher fruits vegetables consumption better performance. Similarly, adherence studies. However, are lacking. This review discusses how current may inform development preventive optimal nutritional policy aimed at combatting

Язык: Английский

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Progress and trends in photodynamic therapy research in oral science: A bibliometric analysis

Photodiagnosis and Photodynamic Therapy, Год журнала: 2024, Номер 48, С. 104261 - 104261

Опубликована: Июнь 27, 2024

Photodynamic therapy is garnering increasing attention in oral science. Despite its promising potential, further exploration warranted to delve into the research paradigms and evolving trends within Therefore, this study aimed conduct a comprehensive bibliometric analysis of photodynamic science (PDTOS), investigating landscapes, identifying key contributors, analyzing collaborative networks, pinpointing emerging directions, exploring factors influencing high citations.

Язык: Английский

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Mapping Theme Trends and Research Frontiers in Dexmedetomidine Over Past Decade: A Bibliometric Analysis

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 3043 - 3061

Опубликована: Июль 1, 2024

Dexmedetomidine, an α

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Sarcopenia and frailty as predictor of outcome in critically ill elderly patients with multiple comorbidities

The Egyptian Journal of Internal Medicine, Год журнала: 2025, Номер 37(1)

Опубликована: Янв. 6, 2025

Abstract Background Frailty and sarcopenia are important conditions that grow more common as people age. Frailty, a multi-system illness linked to heightened vulnerability stresses, sarcopenia, loss of muscle mass function, both raise the likelihood unfavorable health outcomes including disability or death. This work’s objective was study clinical utility frailty in critically ill elderly patients with multiple comorbidities. Patients methods Clinical scale SARC-F questionnaire were done 70 admitted geriatric ICU hospital. Results There highly significant effect on primary whether present not (which means is prominent than sarcopenia). The associated factors admission cause, type comorbidities, outcome (mortality, prolonged hospital stay, long-term care) found be important. presence regarding mean age, degree frailty, higher percentage for need noradrenaline treatment patients, relation patient mortality. Conclusions risk death critical increased by frailty. examinations should routinely identify sarcopenia. By providing appropriate therapies, medical professionals intensive care units may able improve outcomes. Clinicians get prognostic information survival recovery their frail unit assessing at time admission. Crucially, this might assist families making well-informed choices course while they condition. investigation needed ascertain there modifiable elements enhance prognosis sick fragile people.

Язык: Английский

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Evolutionary patterns and research frontiers in autophagy in podocytopathies: a bibliometric analysis

Frontiers in Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 9, 2025

Podocytopathies are a uniquely renal disease syndrome, in which direct or indirect podocyte injury leads to proteinuria nephrotic syndrome. Of the many factors that contribute podocytopathies, abnormal regulation of autophagy, such insufficient excessive autophagy levels, have been proposed play significant role occurrence and development podocytopathies. However, there still has lack systematic comparative research elucidate exact podocytopathies its current status. This study aims utilize bibliometric analysis clarify pathogenesis analyze focus this area, as well explore future trends. We retrieved original articles review papers with respect published between year 2008 2022 from Web Science Core Collection (WOSCC). Then, VOSviewer CiteSpace software were employed reveal leading subjects generate visual maps countries/regions, organizations, authors, journals, keyword networks field. A total 825 publications regarding included, China contributing most followed by United States Japan. Professor Koya Daisuke, He Qiang, Jin Juan prolific researchers Oxidative stress, NLRP3 inflammasome, therapeutic targets knowledge base for special Taken together, helps us hotspots guide directions, provides reference scholars further investigate conduct clinical trial regulators

Язык: Английский

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Sarcopenia As a Predictor of Survival and Complications of Patients With Cirrhosis After Liver Transplantation: A Systematic Review and Meta‐Analysis

Clinical Transplantation, Год журнала: 2025, Номер 39(2)

Опубликована: Янв. 28, 2025

ABSTRACT Introduction This systematic review/meta‐analysis evaluated the impact of sarcopenia in patients with cirrhosis before liver transplantation (LT) on outcomes after LT. Methods A search was conducted six medical databases until February 2022. The primary outcome overall mortality LT, while several secondary including graft survival and rejection, need for transfusions, length intensive care unit (ICU) hospital stay, surgical complications were evaluated. Sub‐group analyses meta‐regression also performed. Results Fifty‐three studies review, which 30, 5875 patients, included meta‐analysis. All cohort good/high quality Newcastle‐Ottawa scale (NOS), our analysis no publication bias found, although there substantial heterogeneity between studies. Muscle mass assessed using skeletal muscle index (SMI) 14 studies, psoas area (PMA) seven (PMI) four prevalence pre‐LT ranged from 14.7% to 88.3%. Pre‐LT significantly associated post‐LT (Relative Risk [RR] = 1.84, 95% CI:1.41,2.39), as well a high risk infections post‐LT, complications, fresh frozen plasma (FFP) ICU stay (LOS). Conclusions is strong factor clinically meaningful adverse Assessment may help identify at highest poor who benefit targeted interventions.

Язык: Английский

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Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian randomization study

Nature and Science of Sleep, Год журнала: 2025, Номер Volume 17, С. 271 - 284

Опубликована: Фев. 1, 2025

Observational studies have demonstrated a strong association between sleep disturbances and frailty. However, the causality remains inconclusive. We aimed to investigate bidirectional causal relationships frailty measures employing two-sample Mendelian randomization (MR) analysis. Two-sample MR analyses were performed based on large-scale genome-wide (GWAS) of European population for index (FI) (N = 175,226), Fried Frailty Score (FFS) 386,565), insomnia 283,595), duration 445,966) apnea 523,366). conducted estimates using inverse variance-weighted method (IVW), with sensitivity MR-Egger, weighted median, mode, pleiotropy residual sum outlier (MR-PRESSO) Cochran's Q test was assess heterogeneity. found that genetically predicted FI associated shorter apnea. The FFS insomnia, duration, In reverse direction analysis, genetic liability short long an increase in FI. Genetic FFS. Our study provided evidence supporting disturbances. findings contribute prevention management

Язык: Английский

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Trends in the immunotherapy for glioblastoma: A two-decade bibliometric analysis

Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)

Опубликована: Фев. 14, 2025

Glioblastoma is a life-threatening primary malignant brain tumor with an unfavorable prognosis. Contributing factors to its poor outcome include heterogeneity, low mutational burden, and immunosuppression within the microenvironment. Recognizing these challenges, immunotherapeutic strategies have emerged as promising avenue for glioblastoma treatment. Although several dynamic research scientific trend increasingly taken pace in approaches glioblastoma, systematic bibliometric studies on such trends are few. On this note, study explores analysis of hotspots immunotherapy. We conducted search Web Science Core Collection database articles immunotherapy published between 2004 2024. Using VOSviewer CiteSpace software, we analyzed collected explore aspects country origin, journal publication, affiliated institute, authorship, keywords, citation patterns. As May 1, 2024, retrieved 3,729 papers Immunotherapy. In field immunotherapy, United States stands out leading contributor, 1,708 publications substantial 90,590 citations. Following closely, China has made significant contributions through 926 publications, earning 17,533 citations, while Germany adds body knowledge 349 16,355 Furthermore, Authoritative journals Clinical Cancer Research Neuro-Oncology. The top five keywords during period were temozolomide, radiotherapy, dendritic cell, cytotoxic T lymphocyte, vaccination. Moreover, Hotspots immune checkpoint inhibitors chimeric antigen receptor cell therapy.

Язык: Английский

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