Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review

Nutrients, Год журнала: 2024, Номер 16(1), С. 177 - 177

Опубликована: Янв. 4, 2024

Marginal vitamin B6 (B6) deficiency is a widespread global concern. Inadequate levels have been linked to an increased risk of age-related chronic diseases such as cardiovascular and cancers. In recent years, the growing concern over sarcopenia (the loss muscle mass strength) frailty (a decline in physiological resilience vulnerability associated with aging) particularly relevant due emergence super-aged societies developed countries. Notably, among thirty-one studies included this review, twenty-five showed significant association status sarcopenia, frailty, all-cause mortality adults (p < 0.05), while six no association. Emerging suggested novel mechanisms underlying These involve P2X7 receptor-mediated NLRP3 inflammasome signaling, AMPK PD-L1 satellite cell-mediated myogenesis. Furthermore, modulation PLP-dependent enzymes impaired metabolic processes, affecting energy utilization, imidazole peptide production, hydrogen sulfide well kynurenine pathway, all which play vital roles skeletal health pathophysiology. This narrative review provides up-to-date assessment our current understanding potential role nutritional combating mortality.

Язык: Английский

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Possible sarcopenia, Sarcopenic obesity phenotypes and their association with diabetes: Evidence from LASI wave-1 (2017-18)

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2025, Номер 19(2), С. 103185 - 103185

Опубликована: Янв. 11, 2025

Язык: Английский

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Relationship Between Body Mass Index and Low Skeletal Muscle Mass in Adults Based on NHANES 2011–2018

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 21, 2025

Sarcopenia, a syndrome characterized by declining muscle mass and function, is associated with various adverse health outcomes. While body index (BMI) fundamental indicator, its relationship sarcopenia complex remains inadequately explored. Low BMI has been linked to loss, but the role of other demographic clinical factors in this unclear. This cross-sectional study analyzed data from NHANES 2011–2018 cohort, including 7,455 adults aged ≥ 20 years. was diagnosed based on appendicular skeletal using DXA criteria. categorized into quartiles for analysis. Weighted multivariable logistic regression assessed associations between low mass, adjusting confounders such as age, gender, ethnicity, income-to-poverty ratio, chronic diseases (e.g., diabetes hypertension). Variance inflation (VIF) confirmed absence multicollinearity. Lower significantly higher odds (adjusted OR: 0.508, 95% CI: 0.483–0.533, p < 0.001), while exhibited protective effect. Age (OR: 1.035, 1.025–1.045, 0.001) female gender 1.570, 1.267–1.949, were independent risk factors. Racial disparities noted, non-Hispanic Black individuals at lower compared Whites 0.242, 0.152–0.384, 0.001). Other significant included alcohol consumption, education smoking status not associated. inversely prevalence, posing odds. The findings underscore importance monitoring addressing multifactorial profiles management prevention.

Язык: Английский

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Sarcopenic obesity and the risk of atrial fibrillation in non-diabetic older adults: a prospective cohort study

Clinical Nutrition, Год журнала: 2025, Номер 47, С. 282 - 290

Опубликована: Март 4, 2025

Язык: Английский

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Reverse epidemiology of obesity paradox: Fact or fiction?

Physiological Reports, Год журнала: 2024, Номер 12(21)

Опубликована: Окт. 29, 2024

Abstract Obesity paradox refers to the clinical observation that when acute cardiovascular decompensation occurs, patients with obesity may have a survival benefit. This apparently runs counter epidemiology of obesity, which increase risk for non‐communicable diseases (NCDs). The scientific community is split on paradox, some supporting it, while others call it BMI paradox. review: (a) defines and its proposed role in overall mortality NCDs; (b) delineates evidence against paradox; (c) presents importance using different indices body mass assess (d) examines metabolically healthy emerging cardio‐respiratory fitness (CRF) as an independent predictor CVD all‐cause with/without obesity. Evidence suggests development insulin resistance are influenced by genetic (or ethnic) make up dietary habits (culture) individuals. Hence, this review lean diabetes, has higher total non‐CVD compared diabetics possibility maternal factors programming cardiometabolic during fetal development, lead paradigm shift our understanding

Язык: Английский

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Association between sarcopenic obesity and risk of frailty in older adults: a systematic review and meta-analysis

Age and Ageing, Год журнала: 2024, Номер 54(1)

Опубликована: Дек. 22, 2024

Abstract Background Age-related changes in body composition such as muscle loss can lead to sarcopenia, which is closely associated with frailty. However, the effect of fat accumulation on frailty old age remains unclear. In particular, association between combination these two conditions, known sarcopenic obesity, and older adults Objective To synthesise obesity risk investigate role age. Methods Six databases were searched from inception 29 September 2024. Two reviewers independently extracted data assessed bias for included observational studies using adapted Newcastle–Ottawa scale. The control groups consisted robust, obese individuals. Meta-analyses performed examine due amongst adults. Results Sixteen eligible meta-analyses 1098 records. Compared robust individuals, more vulnerable [odds ratio (OR), 3.76; 95% confidence interval (CI), 2.62 5.39; I2 = 79.3%; P &lt; .0001]. Obesity was not (OR, 1.23; CI, 0.99 1.53; 0.0%; .501) Conclusions Sarcopenic a high Sarcopenia may have synergistic effects

Язык: Английский

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The diagnosis and treatment of sarcopenia and sarcopenic obesity

Deutsches Ärzteblatt international, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Sarcopenia is a progressive, generalized disease of skeletal muscle characterized by loss strength and mass. The combination obesity sarcopenia called sarcopenic obesity. Because the aging population in many countries around world, are challenge for global health policy. This review based on pertinent publications retrieved selective literature search. effects quality life far-reaching include difficulty coping with everyday life, an increased risk falling, frequent hospitalization, mortality. A population-based study Germany revealed 7% prevalence adults aged 65 above. was 4.5%. Persons above who at should be screened, e.g., SARC-F questionnaire. If screening yields suggestive finding (SARC-F ≥ 4 points), diagnosis confirmed or ruled out measurements (e.g. hand-grip strength, reference values: women <16 kg, men <27 kg) appendicular mass (women <5.5 kg/m2, <7.0 kg/m2). demonstration reduced sufficient to initiate treatment. For obesity, fat additionally required. goal treatment improve mobility reduce negative outcomes. consists resistance training nutritional interventions. targeted structured approach detection can make major contribution maintenance improvement these patients' functionality life.

Язык: Английский

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Systemic Inflammation and Disruption of the Local Microenvironment Compromise Muscle Regeneration: A Critical Pathogenesis of Autoimmune-associated Sarcopenia (Preprint)

Interactive Journal of Medical Research, Год журнала: 2025, Номер 14, С. e64456 - e64456

Опубликована: Фев. 25, 2025

Abstract Sarcopenia is defined by age-related reductions in muscle mass, strength, and physiological function, it especially prevalent among individuals with autoimmune diseases. Autoimmune disorders, characterized immune dysregulation, cause systemic inflammation damage to multiple tissues through unregulated activity. Research indicates that diseases negatively impact skeletal functions may worsen the progression of sarcopenia. This viewpoint comprehensively discusses pathogenesis potential mechanism sarcopenia 3 diseases: inflammatory bowel disease, rheumatoid arthritis, type 1 diabetes mellitus. Mechanistically, chronic microenvironment alterations induce compartment-specific redistribution leukocyte subsets cytokine networks. These perturbations disrupt critical signaling pathways governing protein synthesis, satellite cell activation, mitochondrial bioenergetics, leading impaired regeneration accelerated progression. By delineating shared distinct pathomechanisms across these models, this analysis reframes our understanding immune-mediated wasting. Beyond mechanistic insights, establishes a translational framework for targeted therapies highlights emerging research directions bridging immunology musculoskeletal decline.

Язык: Английский

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Adipositas im Alter – Auswirkungen auf Kraft und -Funktion der Skelettmuskulatur

Adipositas - Ursachen Folgeerkrankungen Therapie, Год журнала: 2025, Номер 19(01), С. 8 - 17

Опубликована: Фев. 28, 2025

Zusammenfassung Die zentrale Bedeutung der Muskelmasse, -kraft und -funktion im Alter ist eindeutig wissenschaftlich belegt. Frage, wie sich eine Adipositas auf die Kraft Funktion Skelettmuskulatur auswirkt, wurde jedoch lange Zeit kaum systematisch untersucht. Diese Arbeit gibt Übersicht über Kohortenstudien zum Zusammenhang von mit Muskelkraft diskutiert zugrundeliegende Ursachen Fettinfiltration, subklinische Inflammation mitochondriale Dysfunktion. zeigen, dass trotz Zunahme des Muskelvolumens negativ beeinflusst, was zu Aktivitätseinschränkungen einem höheren Risiko für Invalidität führen kann. Neue Daten weisen darauf hin, Fettinfiltration Skelettmuskel geringerer Muskelqualität Leistungsfähigkeit assoziiert ist. Weitere Mechanismen Dysfunktion tragen ebenfalls zur Verschlechterung bei.

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Probable and confirmed sarcopenia are still better predictors of disability than sarcopenic obesity following ESPEN/EASO consensus steps

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 15, 2025

Abstract Background Studies comparing different operational definitions of sarcopenia (S) and sarcopenic obesity (SO) defined according to the ‘’European Society for Clinical Nutrition Metabolism European Association Study Obesity’’ (ESPEN/EASO) criteria with functionality are scarce. Our aim is investigate whether SO or S skeletal muscle mass (SMM) adjustments better associated functional disability. Methods This retrospective study was carried out in older individuals ≥ 65 years age a geriatric outpatient clinic. Probable confirmed were evaluated revised Working Group on Sarcopenia Older People (EWGSOP2) criteria, ESPEN/EASO consensus steps. For SMM component both SO, (weight, body index, height square (W, BMI, H 2 respectively)) used. Functional disability examined activities daily living (ADL), instrumental ADL (IADL). Receiver operating characteristic (ROC) curves drawn area under ROC curve (AUC) calculated find which definition best predicts Results Data from 1477 adults screened. 408 participants (median age; 73 (65–101), 65% female) included. Prevelance 6.9%. sarcopenia, BMI-adjusted W-adjusted significantly impaired IADL ( p < 0.001), showed fair accuracy predicting Sarcopenic did not show significant associations didn’t predict Only by BMI predicted poor accuracy. Among probable had highest sensitivity (83.6%) negative predictive value (NPV) (94.2%) Conclusion We found that (with NPV) (BMI-adjusted higher NPV than W-adjusted) most relevant disability, but their diagnostic limited. Confirmed Other definitions, including our study. Future studies need refine its distinct impact impairment compared alone.

Язык: Английский

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