The EPMA Journal, Год журнала: 2024, Номер 16(1), С. 95 - 111
Опубликована: Дек. 18, 2024
Язык: Английский
European Journal of Pharmacology, Год журнала: 2025, Номер 993, С. 177413 - 177413
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1
Molecular Nutrition & Food Research, Год журнала: 2024, Номер 68(10)
Опубликована: Май 1, 2024
Abstract Skeletal muscle can undergo detrimental changes in various diseases, leading to dysfunction and atrophy, thus severely affecting people's lives. Along with exercise, there is a growing interest the potential of nutritional support against atrophy. This review provides brief overview molecular mechanisms driving skeletal atrophy summarizes recent advances interventions for preventing treating The supplements include amino acids their derivatives (such as leucine, β‐hydroxy, β‐methylbutyrate, creatine), antioxidant (like Coenzyme Q10 mitoquinone, resveratrol, curcumin, quercetin, Omega 3 fatty acids), minerals magnesium selenium), vitamins vitamin B, C, D, E), well probiotics prebiotics Lactobacillus, Bifidobacterium, 1‐kestose). Furthermore, study discusses impact combined approach involving physical therapy prevent suggests appropriate multi‐nutritional multi‐modal based on individual conditions optimize treatment outcomes, enhances recovery function patients. By understanding behind implementing interventions, it possible enhance improve patients' quality life.
Язык: Английский
Процитировано
7
Nutrients, Год журнала: 2024, Номер 16(11), С. 1635 - 1635
Опубликована: Май 27, 2024
The acceleration of aging is a risk factor for numerous diseases, and diet has been identified as an especially effective anti-aging method. Currently, research on the relationship between dietary nutrient intake accelerated remains limited, with existing studies focusing small number individual nutrients. Comprehensive single mixed effects nutrients not conducted. This study aimed to comprehensively explore intakes, both singly in combination, aging. Data this were extracted from 2015–2018 National Health Nutrition Examination Surveys (NHANES). was measured by phenotypic age acceleration. Linear regression (linear), restricted cubic spline (RCS) (nonlinear), weighted quantile sum (WQS) (mixed effect) models used association A total 4692 participants aged ≥ 20 included study. In fully adjusted models, intakes 16 negatively associated (protein, vitamin E, A, beta-carotene, B1, B2, B6, K, phosphorus, magnesium, iron, zinc, copper, potassium, fiber, alcohol). Intakes sugars, C, caffeine, alcohol showed significant nonlinear associations Additionally, Single well may mitigate Moderately increasing specific maintaining balance be key strategies prevent
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1967 - 1967
Опубликована: Фев. 25, 2025
Water-soluble B vitamins, mainly obtained through dietary intake of fruits, vegetables, grains, and dairy products, act as co-factors in various biochemical processes, including DNA synthesis, repair, methylation, energy metabolism. These vitamins include B1 (Thiamine), B2 (Riboflavin), B3 (Niacin), B5 (Pantothenic Acid), B6 (Pyridoxine), B7 (Biotin), B9 (Folate), B12 (Cobalamin). Recent studies have shown that besides their fundamental physiological roles, influence oncogenic metabolic pathways, glycolysis (Warburg effect), mitochondrial function, nucleotide biosynthesis. Although deficiencies these are associated with several complications, emerging evidence suggests excessive specific may also contribute to cancer progression interfere therapy due impaired genetic functions. This review discusses the tumor-suppressive tumor-progressive roles cancer. It explores recent on a comprehensive understanding relationship between vitamin metabolism underscores need for further research determine optimal balance prevention therapy.
Язык: Английский
Процитировано
0
Food Science & Nutrition, Год журнала: 2025, Номер 13(1)
Опубликована: Янв. 1, 2025
ABSTRACT Sarcopenia (SP), an age‐associated condition marked by muscle weakness and loss has been strongly connected with metabolic factors according to substantial evidence. Nevertheless, the causal correlation between SP serum metabolites, biological signaling pathways involved, is still not well understood. We performed a bidirectional two‐sample Mendelian randomization (MR) analysis examine relationships 1091 levels 309 ratios of metabolites traits, alongside investigating relevant pathways. Additionally, we explored differential expression plasma potential in animal model SP. When was utilized as outcome, identified 11 robust associations seven metabolite levels/ratios SP‐related traits using Bonferroni's correction (threshold: p < 0.05). verified stable association glycine validation. As for reverse MR analysis, there were strong remaining after multiple contrast correction. pathway showed that metabolism, insulin resistance, cAMP may contribute connection validation various datasets observations metabolomics suggests metabolism Our results indicate biosignaling could serve important circulatory biomarkers screening prevention clinical settings. they represent molecules future exploration mechanisms selection drug targets.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Frailty is an age-related geriatric syndrome, for which the mechanisms remain largely unknown. We performed a longitudinal study of aging female (n = 40) and male 47) C57BL/6NIA mice, measured frailty index derived metabolomics data from plasma samples. identify differentially abundant metabolites related to aging, determine via machine learning approach, generate union set features, both in whole cohort sex-stratified subgroups. Using we perform association build metabolomics-based clock. find that are enriched amino acid metabolism cofactors vitamins, include ergothioneine, tryptophan, alpha-ketoglutarate, present sex dimorphism. B vitamin flavin adenine dinucleotide pyridoxate as female-specific biomarkers, lipid sphingomyelins, glycerophosphoethanolamine glycerophosphocholine male-specific biomarkers. These associations confirmed validation cohort, with ergothioneine perfluorooctanesulfonate identified robust In summary, our results sex-specific metabolite biomarkers shed light on potential involved frailty.
Язык: Английский
Процитировано
0
Clinical Nutrition, Год журнала: 2025, Номер 47, С. 21 - 27
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
0
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Июнь 4, 2024
Background Sarcopenia is associated with oxidative stress. The Oxidative Balance Score (OBS) commonly used to assess dietary and lifestyle exposure However, few studies in the literature have assessed correlation between sarcopenia OBS. Aim This study aimed association OBS among young middle-aged adults United States using data from National Health Nutrition Examination Survey (NHANES). Method Weighted logistic regression analysis was investigate based on NHANES 2011–2018. Subgroup analyses were performed observe consistency of outcomes, stability results tested sensitivity analyses. Result final sample included 5,525 American adults. A higher a lower risk sarcopenia. In fully adjusted model, second (odds ratio [OR]: 0.62, 95% confidence interval [CI]: 0.41, 0.94; p = 0.023), third (OR: 0.50; CI: 0.34, 0.74; < 0.001), highest quartiles 0.18; 0.11, 0.28; 0.001) risks when compared lowest quartile. consistent across both scores. Our subgroup revealed no significant differences subgroups variables interaction analysis. Sensitivity similar results. Conclusion showed that antioxidant may decrease developing Higher scores indicate greater protection against sarcopenia; however, further clinical are warranted confirm these findings.
Язык: Английский
Процитировано
1
Diagnostics, Год журнала: 2024, Номер 14(14), С. 1507 - 1507
Опубликована: Июль 12, 2024
The aims of this study were to examine the effects pyridoxine administration on activities cardiac antioxidant stress enzymes superoxide dismutase (SOD) and catalase (CAT) enzyme indicators cardiometabolic status, lactate malate dehydrogenase (LDH, MDH), as well LDH MDH isoforms' distribution in tissue healthy diabetic Wistar male rats. Experimental animals divided into five groups: C1-control (0.9% sodium chloride-NaCl-1 mL/kg, intraperitoneally (i.p.), 1 day); C2-second control NaCl i.p., 28 days); DM-diabetes mellitus (streptozotocin 100 mg/kg 0.9% NaCl, P-pyridoxine (7 mg/kg, DM + P-diabetes day 7 days). Pyridoxine treatment reduced CAT activity In rats, increased LDH1 decreased LDH4 isoform activities, peroxisomal mitochondrial activities. Our findings highlight positive complex interplay between oxidative stress, enzymes, metabolic changes cardiomyopathy.
Язык: Английский
Процитировано
1
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Апрель 11, 2024
Pyridoxal 5′-phosphate (PLP) is highly valuable in food and medicine. However, achieving the efficient biosynthesis of PLP remains challenging. Here, a salvage pathway using acid phosphatase from Salmonella typhi (StAPase) pyridoxine oxidase Escherichia coli (EcPNPO) as enzymes was established for first time to synthesize (PN) pyrophosphate (PPi). StAPase identified rate-limiting enzyme. Two protein modification strategies were developed based on PN phosphorylation mechanism: (1) improving binding into (2) enhancing hydrophobicity StAPase's substrate pocket. The kcat/Km optimal mutant M7 4.9 times higher than that wild type. detailed mechanism performance improvement analyzed. Under catalysis EcPNPO, high-yielding strain 14.5 ± 0.55 g/L engineered with productivity 1.0 0.02 g/(L h) (the highest date). study suggests promising method industrial-scale production.
Язык: Английский
Процитировано
0