Biomolecules,
Год журнала:
2024,
Номер
15(1), С. 18 - 18
Опубликована: Дек. 26, 2024
The
biological
process
of
aging
is
influenced
by
a
complex
interplay
genetic,
environmental,
and
epigenetic
factors.
Recent
advancements
in
the
fields
epigenetics
senolytics
offer
promising
avenues
for
understanding
addressing
age-related
diseases.
Epigenetics
refers
to
heritable
changes
gene
expression
without
altering
DNA
sequence,
with
mechanisms
like
methylation,
histone
modification,
non-coding
RNA
regulation
playing
critical
roles
aging.
Senolytics,
class
drugs
targeting
eliminating
senescent
cells,
address
accumulation
dysfunctional
cells
that
contribute
tissue
degradation
chronic
inflammation
through
senescence-associated
secretory
phenotype.
This
scoping
review
examines
intersection
senolytic
therapies
aging,
focusing
on
their
combined
potential
therapeutic
interventions.
Senescent
display
distinct
signatures,
such
as
hypermethylation
modifications,
which
can
be
targeted
enhance
efficacy.
Epigenetic
reprogramming
strategies,
induced
pluripotent
stem
may
further
complement
rejuvenating
aged
cells.
Integrating
modulation
therapy
offers
dual
approach
improving
healthspan
mitigating
pathologies.
narrative
underscores
need
continued
research
into
molecular
underlying
these
interactions
suggests
future
directions
development,
including
clinical
trials,
biomarker
discovery,
combination
synergistically
target
processes.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Predicting
health
trajectories
and
accurately
measuring
aging
processes
across
the
human
lifespan
remain
profound
scientific
challenges.
Assessing
effectiveness
impact
of
interventions
targeting
is
even
more
elusive,
largely
due
to
intricate,
multidimensional
nature
aging-a
process
that
defies
simple
quantification.
Traditional
biomarkers
offer
only
partial
perspectives,
capturing
limited
aspects
landscape.
Yet,
over
past
decade,
groundbreaking
advancements
have
emerged.
Epigenetic
clocks,
derived
from
DNA
methylation
patterns,
established
themselves
as
powerful
biomarkers,
capable
estimating
biological
age
assessing
rates
diverse
tissues
with
remarkable
precision.
These
clocks
provide
predictive
insights
into
mortality
age-related
disease
risks,
effectively
distinguishing
chronological
illuminating
enduring
questions
in
gerontology.
Despite
significant
progress
epigenetic
clock
development,
substantial
challenges
remain,
underscoring
need
for
continued
investigation
fully
unlock
their
potential
science
aging.
American Journal of Clinical Nutrition,
Год журнала:
2024,
Номер
120(5), С. 1143 - 1155
Опубликована: Окт. 11, 2024
DNA
methylation
(DNAm)
has
unique
properties
which
makes
it
a
potential
biomarker
for
lifestyle-related
exposures.
Epigenetic
clocks,
particularly
DNAm-based
biological
age
predictors
[epigenetic
(EA)],
represent
an
exciting
new
area
of
clinical
research
and
deviations
EA
from
chronological
acceleration
(EAA)]
have
been
linked
to
overall
health,
age-related
diseases,
environmental
Clinical Epigenetics,
Год журнала:
2024,
Номер
16(1)
Опубликована: Окт. 18, 2024
DNA
methylation
profiling
may
provide
a
more
accurate
measure
of
the
smoking
status
than
self-report
and
be
useful
in
guiding
clinical
interventions
forensic
investigations.
In
current
study,
blood
profiles
nearly
800
Polish
individuals
were
assayed
using
Illuminia
EPIC
inference
from
epigenetic
data
was
explored.
addition,
we
focused
on
role
AHRR
gene
as
top
marker
for
investigated
its
responsiveness
to
other
lifestyle
behaviors.
