Опубликована: Янв. 1, 2024
Язык: Английский
European Journal of Neuroscience, Год журнала: 2024, Номер 60(1), С. 3466 - 3490
Опубликована: Май 10, 2024
Abstract In females, Alzheimer's disease (AD) incidences increases as compared to males due estrogen deficiency after menopause. Estrogen therapy is the mainstay for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. plays crucial role amyloid precursor protein (APP) processing overall neuronal health by regulating various factors such brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes apolipoprotein E (ApoE) polymorphisms. All these impact physiology of postmenopausal women. replacement therapies play an important treatment strategy prevent However, use may lead increased risks breast cancer, venous thromboembolism cardiovascular disease. Various therapeutic approaches have used mitigate effects on AD. These include therapy, Selective Receptor Modulators (SERMs), Beta (ERβ)‐Selective Agonists, Transdermal Delivery, Localised Combination Therapies, Metabolism Modulation Alternative Estrogenic Compounds like genistein from soy, notable phytoestrogen plant sources. mechanism via which modulate women not explained earlier thoroughly. Present review will enlighten all molecular mechanisms Along‐with this, association between estrogen, ApoE polymorphisms also be discussed
Язык: Английский
Процитировано
6
Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137233 - 137233
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Diseases, Год журнала: 2025, Номер 13(2), С. 25 - 25
Опубликована: Янв. 21, 2025
Purpose: To assess the presence and quantity of CD34+ hematopoietic stem cells in patients with Alzheimer’s disease (AD) through a meta-analysis. Methods: A systematic search databases identified observational interventional studies reporting baseline cell counts AD patients. The data on mean measures variation were extracted. Standardized differences (SMDs) calculated using common random effects models to compare between controls. Heterogeneity among was evaluated tau2, tau, I2 statistics. risk bias assessed Newcastle–Ottawa Scale ROBINS-I tool. Patients: Five included, comprising four one open-label trial, total 271 participants (139 132 controls). Results: meta-analysis indicated an increase when compared model showed moderate SMD 0.2964 (95% CI:0.0490–0.5437). However, yielded non-significant 0.2326 CI: −0.4832–0.9484). Significant heterogeneity observed (I2 = 87.1%, p < 0.0001). Conclusion: may exhibit higher circulating than controls, but substantial potential biases limit definitive conclusions.
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2025, Номер 95, С. 102818 - 102818
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
NeuroMarkers., Год журнала: 2025, Номер 2(2), С. 100041 - 100041
Опубликована: Март 8, 2025
Язык: Английский
Процитировано
0
GeroScience, Год журнала: 2025, Номер unknown
Опубликована: Март 15, 2025
Abstract Geroscience has helped to usher in a new and exciting era of aging drug development evaluation novel repurposed agents, as well natural compounds purported target one or more hallmarks. Among the latter, curcumin long been pursued promising strategy but failed provide convincing evidence human trials. Oral intake is typical route administration tested for vast majority gerotherapeutic candidates, including curcumin, efficacy dependent upon good oral bioavailability pharmacokinetics. However, unlike FDA-approved medications, many compounds, such have poor bioavailability, which may explain their limited success translation. To overcome these inherent limitations, we solvent-based formulation concentrated (VASCEPTOR®), developed effective skin penetration delivery high amounts bioactive curcuminoids directly circulation on age-related conditions. We demonstrate that short-term topical treatment (7.5 mg per dose) with VASCEPTOR® twice week can improve both vascular health rat model hypertension, while late-life intervention aged mice improves multiple indices span, improved exercise tolerance, motor coordination, diastolic function ( p < 0.05), reduction frailty status 0.05) expression some markers tissues, particular heart kidney. Thus, data suggest therapeutic potential potentially be dramatically enhanced by and, along other should prioritized further development, testing deployment manifestations humans.
Язык: Английский
Процитировано
0
Frontiers in Aging, Год журнала: 2025, Номер 6
Опубликована: Март 21, 2025
Background and objective Alzheimer’s disease (AD) presents profound challenges, significantly impairing quality of life (QOL) for patients increasing the burden on caregivers. This study aims to investigate effectiveness a tailored 12-week yoga intervention in improving individuals with mild moderate AD reducing caregiver (CB). Methods is interventional healthy controls enrolled 30 participants (18 males, 12 females) diagnosed by an expert neurologist. Participants were aged 60 years or older recruited from old age home. A program, including specific postures (asanas), pranayama (breathing exercises), meditation, was conducted 1 hour daily, 6 days week. Neurocognitive assessments performed pre- post-intervention using Geriatric Depression Scale (GDS), Montreal Cognitive Assessment (MoCA), Caregiver Burden (CB) Scale. MoCA scores analyzed across domains, language, memory, attention, visuospatial ability, delayed recall, abstraction, orientation. Results The led significant improvements quality-of-life measures. GDS decreased 8.36 ± 2.79 5.13 3.07 (P < 0.01; 95% CI: −3.98 −2.31), while total improved 18.23 4.90 21.10 5.09 2.17–3.89). Domain-specific also showed enhancements, particularly recall. burden, measured CB Scale, demonstrated notable reductions following −2.54 −1.23). Conclusion underscores depression cognitive function, overall AD. Additionally, alleviated highlighting its potential as effective mind-body approach management.
Язык: Английский
Процитировано
0
Bioorganic Chemistry, Год журнала: 2025, Номер unknown, С. 108502 - 108502
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(12), С. 9833 - 9844
Опубликована: Июнь 26, 2024
Abstract Diabetes is one of the most common endocrine metabolic diseases and associated with accumulation beta-amyloid plaques in brain. Amyloid beta (Aβ) abnormal tau proteins are effective development Alzheimer’s disease. The aim this study to investigate therapeutic protective effects curcumin on protein expression levels, as well biochemical oxidative changes streptozotocin-induced diabetes rats. comprised five groups, each consisting eight rats: control, diabetic, curcumin, during diabetic induction, post-diabetic induction. Groups 2 4 were administered a single dose 45 mg/kg streptozotocin day 1, while group 5 received it 28. Curcumin was orally via gavage at 100 mg/kg/day for 35 days third, fourth, fifth groups. At end trial (day 35), blood sugar levels insulin resistance similar between control curcumin-treated groups but significantly higher ( P < 0.05). effect tested induction active diabetes. results indicated that rats displayed increased Aβ, protein, total oxidant capacity (TOS) compared Additionally, antioxidant (TAS) lower Aβ both serum brain treated > In addition, TAS following than pre-induction TOS prior However, no significant difference observed above show has an reducing stress caused by increasing activity.
Язык: Английский
Процитировано
3
Nutrients, Год журнала: 2024, Номер 16(21), С. 3751 - 3751
Опубликована: Окт. 31, 2024
Fructus (SCF) is a traditional medicinal herb containing lignans that improves glucose metabolism by mitigating insulin resistance. We aimed to investigate the therapeutic potential and action mechanism of SCF for Alzheimer's disease (AD) using network pharmacology analysis, followed experimental validation in an AD rat model.
Язык: Английский
Процитировано
3