ADVANCES IN BIOLOGICAL THERAPIES FOR NEUROSURGICAL ANESTHESIA: A NARRATIVE REVIEW OF MONOCLONAL ANTIBODIES AND GENE THERAPY APPLICATIONS IN BRAIN TUMOR MANAGEMENT AND NEURODEGENERATIVE DISEASES DOI Creative Commons

Giulia Canello Machado,

Beatriz Viana Souto da Silva,

Elena Antunes de Vasconcelos

и другие.

Revista Ibero-Americana de Humanidades, Ciências e Educação, Год журнала: 2024, Номер 10(8), С. 2517 - 2523

Опубликована: Авг. 21, 2024

Neurosurgical anesthesia has seen significant progress with the introduction of biological therapies, particularly monoclonal antibodies and gene therapy. These novel treatments hold immense potential in management complex neurological conditions, notably brain tumors neurodegenerative diseases. The promise that target specific antigens as adjuvant therapies for aggressive malignancies like glioblastoma, therapy's objective to correct genetic abnormalities responsible various disorders, are noteworthy. This narrative review aims provide a comprehensive overview current research, challenges, future directions these context neurosurgical anesthesia.

Язык: Английский

Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review DOI Creative Commons
Maroua Jalouli, Md. Ataur Rahman, Partha Biswas

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Янв. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Язык: Английский

Процитировано

7

Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders DOI Creative Commons
Guangming Zhang,

Huayuan Wei,

Anliu Zhao

и другие.

Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)

Опубликована: Фев. 7, 2025

Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.

Язык: Английский

Процитировано

3

Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies DOI
Azhagu Madhavan Sivalingam

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102519 - 102519

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

5

Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities DOI
Yuqing Liu, Lei Wu, Weijun Peng

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 104, С. 102638 - 102638

Опубликована: Дек. 12, 2024

Язык: Английский

Процитировано

5

The role of inflammation in neurological disorders: a brief overview of multiple sclerosis, Alzheimer’s, and Parkinson’s disease’ DOI Creative Commons
Yahveth Cantero‐Fortiz, Merçé Boada

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Окт. 29, 2024

Neuroinflammation is a central feature in the pathophysiology of several neurodegenerative diseases, including MS, AD, and PD. This review aims to synthesize current research on role inflammation these conditions, emphasizing potential inflammatory biomarkers for diagnosis treatment. We highlight recent findings mechanisms neuroinflammation, utility disease differentiation, implications therapeutic strategies. Advances understanding pathways offer promising avenues developing targeted interventions improve patient outcomes. Future should focus validating larger cohorts integrating them into clinical practice enhance diagnostic accuracy efficacy.

Язык: Английский

Процитировано

4

Core-shell structured nanomembrane with sequential immune and vascular isolation effects followed by chondrogenic induction to promote stable stem cell-based subcutaneous cartilage regeneration in large animals DOI
Erji Gao, Ziming Wang, Shaohua Zhao

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 154878 - 154878

Опубликована: Авг. 15, 2024

Язык: Английский

Процитировано

3

Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease DOI Creative Commons
Xiaowei Sun,

Rou Gu,

Jie Bai

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Авг. 17, 2024

Parkinson's disease (PD) is the second most common neurodegenerative disease, and its hallmark pathological features are loss of dopaminergic (DA) neurons in midbrain substantia nigra pars compacta (SNpc) accumulation alpha-synuclein (α-syn). It has been shown that integrity blood-brain barrier (BBB) damaged PD patients, a large number infiltrating T cells inflammatory cytokines have detected cerebrospinal fluid (CSF) brain parenchyma patients animal models, including significant change proportion different CD4

Язык: Английский

Процитировано

3

Neutrophils: Linking Inflammation to Thrombosis and Unlocking New Treatment Horizons DOI Open Access
Haokun Li, Wei Shan, Xi Zhao

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1965 - 1965

Опубликована: Фев. 25, 2025

Neutrophils play a key role in inflammatory responses and thrombosis, but their complex interactions disease pathogenesis are not fully understood. This review examines the multifaceted roles of neutrophils, focusing on activation, cytokine release, formation neutrophil extracellular traps (NETs), which contribute to host defense thrombosis. We discuss interaction between inflammation coagulation, direct effect neutrophils thrombus stability, involvement pathological thrombotic diseases. The therapeutic potential drug loading treatment as well clinical implications future research directions, highlighted. aim this is gain insight into critical neutrophil-inflammation-thrombus axis its target for diseases suggest possible directions neutrophil-loaded therapy

Язык: Английский

Процитировано

0

Nature's Neuroprotector: Honokiol and Its Promise for Alzheimer's and Parkinson's DOI Creative Commons
Ahsas Goyal,

Anshika Kumari,

Aanchal Verma

и другие.

Brain Disorders, Год журнала: 2025, Номер unknown, С. 100208 - 100208

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Identification of housekeeping gene for future studies exploring effects of cryopreservation on gene expression in shrimp DOI Creative Commons

Yen-Po Chen,

Chenming Hu,

Sujune Tsai

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 1, 2025

Abstract Few studies have investigated the subcellular effects of low temperature on gene expression in shrimp and most other crustaceans. Before analysis is conducted, suitable housekeeping genes (HKGs) must be confirmed to account for differences reverse transcription process efficiency among samples. Thus, this study aimed verify five frequently used HKGs, namely 18S ribosomal RNA (18S rRNA), ATPase, histone 3, β-actin, glyceraldehyde 3-phosphate dehydrogenase (gapdh) use experiments assessing molecular-scale cryopreservation coral banded ( Stenopus hispidus ) embryos. To conduct chilling studies, we subjected S. embryos incubation at either 26 °C (control) or 5 0, 4, 8, 16, 32 h. The software tools GeNorm, NormFinder, Bestkeeper were employed identify HKG. GeNorm identified 3 rRNA as stable genes. By contrast, NormFinder determined that a eye-formation pre-hatch stage Finally, gapdh β-actin are This first HKGs studying temperatures. Its findings can aid future research evaluating

Язык: Английский

Процитировано

0