In Silico Pharmacology, Год журнала: 2025, Номер 13(2)
Опубликована: Апрель 16, 2025
Язык: Английский
Antioxidants, Год журнала: 2025, Номер 14(4), С. 372 - 372
Опубликована: Март 21, 2025
Mitochondria are of great importance in cell biology since they major sites adenosine triphosphate (ATP) production and widely involved different cellular pathways the response to stress. During ATP production, reactive oxygen species (ROS) can be produced. While a small amount ROS may important for regulation physiological processes, at elevated levels turn into harmful agents leading damage. From pathological perspective, it could particularly interesting focus on mitochondrial function endothelial cells development aging onset diseases, including renal, cardio-metabolic, liver neurodegenerative ones. However, date, there no surveys which address above issues. To fill this gap, valuable collect recent findings about role mitochondria function, not only increase knowledge but also clinical applications. Here, we overview most issues view characterizing as an innovative potential target prevention aging, well treatment conditions.
Язык: Английский
Процитировано
0
Foods, Год журнала: 2025, Номер 14(7), С. 1091 - 1091
Опубликована: Март 21, 2025
Resveratrol is the most important biopotential phytoalexin of stilbene group (natural polyphenolic secondary metabolites), synthesized naturally by action biotic and abiotic factors on plant. The yield individual bioactive compounds isolated from grapevine components, products by-products directly dependent conditions synthesis, extraction identification techniques used. Modern methods synthesis extraction, as well techniques, are centred use non-toxic solvents that have advantages realisation rapid extractions, maintenance optimal parameters, low energy consumption; this a challenge with promising results for various industrial applications. Actionable advances in identifying analysing stilbenes consist coupling synthesis/extraction/identification proven accurate, reproducible efficient. main remains to keep resveratrol compositionally unaltered while increasing its microbiome solubility stability nutraceutical food industry.
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(4), С. 393 - 393
Опубликована: Март 27, 2025
Background: Autophagy, a catabolic process essential for maintaining cellular homeostasis, declines with age and unhealthy lifestyles, contributing to neurodegenerative diseases. Probiotics, including Milmed yeast, have demonstrated anti-inflammatory antioxidant properties. This study evaluated the activity of on BV-2 microglial cells in vitro vivo model Caenorhabditis elegans (C. elegans) restoring autophagic processes. Methods: were incubated S. cerevisiae (Milmed treated yeast or untreated yeast) then stimulated lipopolysaccharide (LPS). mRNAs factors enzymes assessed by qPCR; mTOR NRF2 ELISA. pNRF2 compared cytosolic was immunofluorescence. The longevity, body size, reactive oxygen species (ROS) levels C. measured fluorescence microscopy. Results: Treatment YPD cultured dried powder obtained from it promoted flux, as shown increased expression Beclin-1, ATG7, LC3, p62 inhibition mTOR, It also enhanced response increasing NRF2, SOD1, GPX; moreover, enhanced, dietary supplementation prolonged survival reduced age-related ROS accumulation without changing gst-4. pro-longevity effect found be dependent SKN-1/Nrf2 activation, absence benefit skn-1 mutants. Conclusions: demonstrates significant pro-autophagy effects elegans, thereby extending lifespan improving stress resistance, which, together previously activity, highlights its role highly effective probiotic beneficial health effects. Activation SKN-1/NRF2 pathway modulation autophagy support therapeutic potential neuroprotection healthy aging.
Язык: Английский
Процитировано
0
In Silico Pharmacology, Год журнала: 2025, Номер 13(2)
Опубликована: Апрель 16, 2025
Язык: Английский
Процитировано
0