Revista Ibero-Americana de Humanidades, Ciências e Educação,
Год журнала:
2024,
Номер
10(8), С. 2517 - 2523
Опубликована: Авг. 21, 2024
Neurosurgical
anesthesia
has
seen
significant
progress
with
the
introduction
of
biological
therapies,
particularly
monoclonal
antibodies
and
gene
therapy.
These
novel
treatments
hold
immense
potential
in
management
complex
neurological
conditions,
notably
brain
tumors
neurodegenerative
diseases.
The
promise
that
target
specific
antigens
as
adjuvant
therapies
for
aggressive
malignancies
like
glioblastoma,
therapy's
objective
to
correct
genetic
abnormalities
responsible
various
disorders,
are
noteworthy.
This
narrative
review
aims
provide
a
comprehensive
overview
current
research,
challenges,
future
directions
these
context
neurosurgical
anesthesia.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9859 - 9859
Опубликована: Сен. 12, 2024
Histamine
(HA),
a
biogenic
monoamine,
exerts
its
pleiotropic
effects
through
four
H1R–H4R
histamine
receptors,
which
are
also
expressed
in
brain
tissue.
Together
with
the
projections
of
HA-producing
neurons
located
within
tuberomammillary
nucleus
(TMN),
innervate
most
areas
brain,
they
constitute
histaminergic
system.
Thus,
while
remaining
mediator
inflammatory
reaction
and
immune
system
function,
HA
acts
as
neurotransmitter
modulator
other
systems
central
nervous
(CNS).
Although
detailed
causes
still
not
fully
understood,
neuroinflammation
seems
to
play
crucial
role
etiopathogenesis
both
neurodevelopmental
neurodegenerative
(neuropsychiatric)
diseases,
such
autism
spectrum
disorders
(ASDs),
attention-deficit/hyperactivity
disorder
(ADHD),
Alzheimer’s
disease
(AD)
Parkinson’s
(PD).
Given
increasing
prevalence/diagnosis
these
their
socioeconomic
impact,
need
develop
effective
forms
therapy
has
focused
researchers’
attention
on
brain’s
activity
related
signaling
pathways.
This
review
presents
current
state
knowledge
concerning
involvement
CNS
development
disorders.
To
this
end,
roles
neurotransmission,
neuroinflammation,
neurodevelopment
discussed.
Revista Ibero-Americana de Humanidades, Ciências e Educação,
Год журнала:
2024,
Номер
10(8), С. 2517 - 2523
Опубликована: Авг. 21, 2024
Neurosurgical
anesthesia
has
seen
significant
progress
with
the
introduction
of
biological
therapies,
particularly
monoclonal
antibodies
and
gene
therapy.
These
novel
treatments
hold
immense
potential
in
management
complex
neurological
conditions,
notably
brain
tumors
neurodegenerative
diseases.
The
promise
that
target
specific
antigens
as
adjuvant
therapies
for
aggressive
malignancies
like
glioblastoma,
therapy's
objective
to
correct
genetic
abnormalities
responsible
various
disorders,
are
noteworthy.
This
narrative
review
aims
provide
a
comprehensive
overview
current
research,
challenges,
future
directions
these
context
neurosurgical
anesthesia.
