ADVANCES IN BIOLOGICAL THERAPIES FOR NEUROSURGICAL ANESTHESIA: A NARRATIVE REVIEW OF MONOCLONAL ANTIBODIES AND GENE THERAPY APPLICATIONS IN BRAIN TUMOR MANAGEMENT AND NEURODEGENERATIVE DISEASES DOI Creative Commons

Giulia Canello Machado,

Beatriz Viana Souto da Silva,

Elena Antunes de Vasconcelos

et al.

Revista Ibero-Americana de Humanidades, Ciências e Educação, Journal Year: 2024, Volume and Issue: 10(8), P. 2517 - 2523

Published: Aug. 21, 2024

Neurosurgical anesthesia has seen significant progress with the introduction of biological therapies, particularly monoclonal antibodies and gene therapy. These novel treatments hold immense potential in management complex neurological conditions, notably brain tumors neurodegenerative diseases. The promise that target specific antigens as adjuvant therapies for aggressive malignancies like glioblastoma, therapy's objective to correct genetic abnormalities responsible various disorders, are noteworthy. This narrative review aims provide a comprehensive overview current research, challenges, future directions these context neurosurgical anesthesia.

Language: Английский

Targeting Protein Aggregation: the Promising Application of Polyoxometalates in Neurodegenerative Diseases DOI
Junyi Chen,

Wenzhu Yang,

Huilan Chen

et al.

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Recent progress in the therapeutic applications of polyoxometalates (POMs) to target protein aggregates neurodegenerative diseases (NDDs) is reviewed.

Language: Английский

Citations

1
Histaminergic System Activity in the Central Nervous System: The Role in Neurodevelopmental and Neurodegenerative Disorders DOI Open Access
Dariusz Szukiewicz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9859 - 9859

Published: Sept. 12, 2024

Histamine (HA), a biogenic monoamine, exerts its pleiotropic effects through four H1R–H4R histamine receptors, which are also expressed in brain tissue. Together with the projections of HA-producing neurons located within tuberomammillary nucleus (TMN), innervate most areas brain, they constitute histaminergic system. Thus, while remaining mediator inflammatory reaction and immune system function, HA acts as neurotransmitter modulator other systems central nervous (CNS). Although detailed causes still not fully understood, neuroinflammation seems to play crucial role etiopathogenesis both neurodevelopmental neurodegenerative (neuropsychiatric) diseases, such autism spectrum disorders (ASDs), attention-deficit/hyperactivity disorder (ADHD), Alzheimer’s disease (AD) Parkinson’s (PD). Given increasing prevalence/diagnosis these their socioeconomic impact, need develop effective forms therapy has focused researchers’ attention on brain’s activity related signaling pathways. This review presents current state knowledge concerning involvement CNS development disorders. To this end, roles neurotransmission, neuroinflammation, neurodevelopment discussed.

Language: Английский

Citations

1
ADVANCES IN BIOLOGICAL THERAPIES FOR NEUROSURGICAL ANESTHESIA: A NARRATIVE REVIEW OF MONOCLONAL ANTIBODIES AND GENE THERAPY APPLICATIONS IN BRAIN TUMOR MANAGEMENT AND NEURODEGENERATIVE DISEASES DOI Creative Commons

Giulia Canello Machado,

Beatriz Viana Souto da Silva,

Elena Antunes de Vasconcelos

et al.

Revista Ibero-Americana de Humanidades, Ciências e Educação, Journal Year: 2024, Volume and Issue: 10(8), P. 2517 - 2523

Published: Aug. 21, 2024

Neurosurgical anesthesia has seen significant progress with the introduction of biological therapies, particularly monoclonal antibodies and gene therapy. These novel treatments hold immense potential in management complex neurological conditions, notably brain tumors neurodegenerative diseases. The promise that target specific antigens as adjuvant therapies for aggressive malignancies like glioblastoma, therapy's objective to correct genetic abnormalities responsible various disorders, are noteworthy. This narrative review aims provide a comprehensive overview current research, challenges, future directions these context neurosurgical anesthesia.

Language: Английский

Citations

0