Bridging the gap between GLP1-receptor agonists and cardiovascular outcomes: evidence for the role of tirzepatide
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Июль 10, 2024
Abstract
Tirzepatide
is
a
new
drug
targeting
glucagon-like
peptide
1(GLP1)
and
gastric
inhibitory
polypeptide
(GIP)
receptors.
This
has
demonstrated
great
potential
in
improving
the
clinical
outcomes
of
patients
with
type
2
diabetes.
It
can
lead
to
weight
loss,
better
glycemic
control,
reduced
cardiometabolic
risk
factors.
GLP1
receptor
agonists
have
been
proven
effective
antidiabetic
medications
possible
cardiovascular
benefits.
Even
though
they
reduce
major
adverse
events,
their
effectiveness
treating
heart
failure
unknown.
Unlike
traditional
agonists,
tirzepatide
more
selective
for
GIP
receptor,
resulting
balanced
activation
these
review
article
discusses
mechanisms
may
use
improve
health.
That
includes
anti-inflammatory
effect,
ability
cell
death
promote
autophagy,
also
its
indirect
effects
through
blood
pressure,
obesity,
glucose/lipid
metabolism.
Additionally,
benefit
atherosclerosis
lower
cardiac
events.
Currently,
trials
are
underway
evaluate
safety
efficacy
failure.
Overall,
tirzepatide’s
dual
agonism
receptors
appears
provide
encouraging
benefits
beyond
offering
therapeutic
option
diseases
Graphical
abstract
Язык: Английский
The link between diabetes and cardiovascular disease
Atherosclerosis,
Год журнала:
2024,
Номер
394, С. 117607 - 117607
Опубликована: Май 29, 2024
Язык: Английский
Comparison Between SGLT2 Inhibitors and Lactation: Implications for Cardiometabolic Health in Parous Women
Metabolic Syndrome and Related Disorders,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 21, 2024
Sodium-glucose
cotransporter-2
(SGLT2)
inhibition
and
lactation
result
in
the
excretion
of
large
amounts
glucose
urine
or
milk
are
associated
with
a
lower
risk
cardiovascular
events.
The
respective
mechanisms
behind
this
association
protection
not
clear.
This
review
compares
contribution
noninsulin-mediated
transport
during
pharmacologic
SGLT2
terms
implications
for
cardiometabolic
health
parous
women.
search
topics
used
to
obtain
information
on
inhibitors
included
action,
atherosclerosis,
heart
failure.
composition.
Subsequent
reference
searches
retrieved
articles
were
also
used.
Active
treatment
affects
sodium
kidneys
predominantly
protects
against
hospitalization
failure
soon
after
onset
therapy.
stimulates
into
mammary
gland
improves
subclinical
clinical
atherosclerotic
vascular
disease
years
delivery.
Both
have
effects
variety
transporters.
Several
been
proposed
explain
benefits
lactation.
Learning
from
similarities
differences
between
both
processes
will
advance
our
understanding
all
people.
Язык: Английский
Specular microscopy findings in diabetic patients: a systematic review and meta-analysis
Clinical Diabetes and Endocrinology,
Год журнала:
2024,
Номер
10(1)
Опубликована: Дек. 10, 2024
To
evaluate
the
specular
microscopy
findings
in
patients
with
diabetes
mellitus
(DM)
through
a
systematic
review
and
meta-analysis.
Язык: Английский
Impact of baseline FIB-4 score on efpeglenatide benefits on cardiovascular outcomes in people with type 2 diabetes: a participant-level exploratory analysis of the AMPLITUDE-O trial
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Сен. 28, 2024
Язык: Английский