The
thesis
provides
an
overview
and
tries
to
explain
the
nationwide
trends
variations
of
primary
radiotherapy
use
in
non-metastatic
stages
cancer
types
often
seen
at
radiotherapeutic
facilities:
lung
–
both
non-small
cell
(NSCLC)
small
(SCLC),
breast
ductal
carcinoma
in-situ
(DCIS)
invasive
cancer,
prostate
rectal
cancer.
utilization
rates
were
investigated
broader
context
multidisciplinary
treatment
these
tumor
types.
Data
from
Netherlands
Cancer
Registry
used
provide
insights.
Respirology,
Год журнала:
2020,
Номер
25(S2), С. 49 - 60
Опубликована: Июль 30, 2020
Surgical
resection
remains
the
only
effective
means
of
cure
in
vast
majority
patients
with
early-stage
lung
cancer.
It
can
be
performed
via
a
traditional
open
approach
(particularly
thoracotomy)
or
minimally
invasive
approach.
VATS
is
'keyhole'
surgery
chest,
and
was
first
used
for
cancer
early
1990s.
Since
then,
large
volume
evolving
clinical
evidence
has
confirmed
that
offered
proven
safety
feasibility,
better
patient-reported
post-operative
outcomes,
less
surgical
trauma
as
quantified
by
objective
outcome
measures
equivalent
survival
than
surgery.
This
firmly
established
choice
today.
Although
impressive
new
non-surgical
therapies
have
emerged
recent
years,
also
being
constantly
rejuvenated
development
'next
generation'
techniques,
refinement
sublobar
selected
patients,
utilization
bespoke
recovery
programmes
synthesis
into
multi-modality
therapy.
There
little
doubt
will
remain
gold
standard
foreseeable
future.
Translational Lung Cancer Research,
Год журнала:
2021,
Номер
10(4), С. 1608 - 1622
Опубликована: Апрель 1, 2021
Microwave
ablation
of
lung
nodules
may
provide
a
faster,
larger
and
more
predictable
zone
than
other
energy
sources,
while
bronchoscopic
transbronchial
has
theoretical
advantage
fewer
pleural-based
complications
percutaneous
approach.
Our
study
aims
to
determine
whether
the
novel
combination
approach
microwave
in
management
is
technically
feasible,
safe
effective.This
retrospective
analysis
single
center
experience
electromagnetic
navigation
bronchoscopy
hybrid
operating
room.
Patients
had
high
surgical
risks
were
either
proven
malignant
or
radiologically
suspicious.
Primary
endpoints
include
technical
feasibility
safety.Total
30
from
25
patients
treated.
Mean
nodule
size
was
15.1
mm,
bronchus
directly
leads
(bronchus
sign
positive)
only
half
them.
Technical
success
rate
100%,
although
some
required
double
for
adequate
coverage.
minimal
margin
5.51
mm.
The
mean
actual
volume
-21.4%
compared
predicted,
likely
due
significant
tissue
contraction
ranging
0-43%.
There
no
heat
sink
effect.
hospital
stay
1.73
days,
1
patient
stayed
3
days.
Complications
included
pain
(13.3%),
pneumothorax
requiring
drainage
(6.67%),
post-ablation
reaction
pleural
effusion
(3.33%)
hemoptysis
(3.33%).
After
median
follow
up
12
months,
none
evidence
progression.Bronchoscopic
feasible
treatment
nodules.
Prospective
on
clinical
application
this
technique
warranted.
Journal of Thoracic and Cardiovascular Surgery,
Год журнала:
2018,
Номер
157(1), С. 362 - 373.e8
Опубликована: Сен. 16, 2018
Stereotactic
body
radiation
therapy
is
the
preferred
treatment
modality
for
patients
with
inoperable
early-stage
non-small
cell
lung
cancer.
However,
comparative
outcomes
between
stereotactic
and
surgery
high-risk
remain
controversial.
The
primary
aim
of
present
meta-analysis
was
to
assess
overall
survival
in
matched
unmatched
patient
cohorts
undergoing
or
surgery.
Secondary
end
points
included
cancer-specific
survival,
disease-free
disease
recurrence,
perioperative
outcomes.
Journal of Thoracic Disease,
Год журнала:
2019,
Номер
11(6), С. 2628 - 2638
Опубликована: Июнь 1, 2019
Lung
cancer
is
the
leading
cause
of
cancer-related
death
worldwide
and
lobectomy
remains
standard
care
for
patients
with
early-stage
non-small
cell
lung
(NSCLC).
The
combination
an
aging
population
implementation
low-dose
CT
screening
to
increase
in
diagnosis
early
stage
NSCLC
medically
"inoperable"
patients.
recommended
treatment
this
latter
group
stereotactic
body
radiation
therapy
(SBRT).
However,
many
cannot
undergo
SBRT
because
they
have
received
prior
or
tumor
located
next
vital
structures.
Percutaneous
ablative
therapies
become
alternative
but,
unfortunately,
all
violate
pleura
are
associated
high
rate
pneumothorax.
With
a
more
favorable
safety
profile
ability
provide
also
nodal
staging,
bronchoscopic
ablation
hence
emerging
as
potential
future
therapeutic
these
Herein
we
review
current
state
art
including
animal
human
data
that
exists
thus
far.
We
discuss
technical
research
challenges
well
directions
exciting
new
technology
may
take.
