Robotic bronchoscopy for pulmonary lesions: a review of existing technologies and clinical data

Journal of Thoracic Disease, Год журнала: 2020, Номер 12(6), С. 3279 - 3286

Опубликована: Июнь 1, 2020

Bronchoscopic interventions are preferred for sampling suspicious pulmonary lesions as they have lower complications and can achieve diagnosis staging in one single procedure. Limitations existing guided bronchoscopy platforms has led to developments robotic assisted technologies. These devices may allow the bronchoscopist more precisely maneuver scope instruments into periphery of lungs under direct visualization while also ensuring stability during target lesions. potential improve diagnostic yield peripheral lung play a role treatment non-operable or oligometastatic tumors using bronchoscopic ablative therapies. In this article, we review technologies summarize available pre-clinical clinical data supporting their use.

Язык: Английский

---

Bioengineering a Light-Responsive Encapsulin Nanoreactor: A Potential Tool for In Vitro Photodynamic Therapy

ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(7), С. 7977 - 7986

Опубликована: Фев. 15, 2021

Encapsulins, a prokaryotic class of self-assembling protein nanocompartments, are being re-engineered to serve as "nanoreactors" for the augmentation or creation key biochemical reactions. However, approaches that allow encapsulin nanoreactors be functionally activated with spatial and temporal precision lacking. We report construction light-responsive nanoreactor "on demand" production reactive oxygen species (ROS). Herein, encapsulins were loaded fluorescent flavoprotein mini-singlet generator (miniSOG), biological photosensitizer is by blue light generate ROS, primarily singlet (1O2). established nanocompartments stably encased miniSOG in response able mediate photoconversion molecular into ROS. Using an vitro model lung cancer, we showed ROS generated triggered photosensitized oxidation reactions which exerted toxic effect on tumor cells, suggesting utility photodynamic therapy. This thus represents platform light-controlled initiation and/or modulation ROS-driven processes biomedicine biotechnology.

Язык: Английский

---

Malignant Central Airway Obstruction

Clinics in Chest Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

---

Microwave ablation of lung tumors: A probabilistic approach for simulation‐based treatment planning

Medical Physics, Год журнала: 2021, Номер 48(7), С. 3991 - 4003

Опубликована: Май 9, 2021

Microwave ablation (MWA) is a clinically established modality for treatment of lung tumors. A challenge with existing application MWA, however, local tumor progression, potentially due to failure establish an adequate margin. This study presents robust simulation-based planning methodology assist operators in comparatively assessing thermal profiles and likelihood achieving specified minimum margin as function candidate applied energy parameters.We employed biophysical probabilistic evaluate the parameters (i.e., power duration given applicator position within tumor). set simulations varying tissue properties was evaluated each considered combination duration, four different scenarios contrast between normal lung. graph then assembled, where distributions achieved zone margins collateral damage volumes can be assessed combinations. For chosen time combination, operator also visualize histogram boundaries overlaid on target volumes. We assembled graphs generic 1, 2, 2.5 cm diameter spherically shaped tumors illustrated impact heterogeneity delivered plans resulting histograms. Finally, we two example patient-specific cases irregular shapes.The indicate that 30 W, 6 min ablations achieve 5-mm across all simulated 1-cm spherical tumors, 70 10 3-mm 90% 2.5-cm tumor. Different revealed 2 overall difference order reliably 4-mm or larger 2-cm tumor.An approach microwave account specific geometry site, property uncertainty,

Язык: Английский

---

Advances in Diagnostic Bronchoscopy

Diagnostics, Год журнала: 2021, Номер 11(11), С. 1984 - 1984

Опубликована: Окт. 26, 2021

The increase in incidental discovery of pulmonary nodules has led to more urgent requirement tissue diagnosis. peripheral are especially challenging for clinicians. There various modalities diagnosis and sampling lesions, but most these have their own limitations. This the development many advanced technical modalities, which empowered pulmonologists reach periphery lung safely effectively. These techniques include thin/ultrathin bronchoscopes, radial probe endobronchial ultrasound (RP-EBUS), navigation bronchoscopy—including virtual bronchoscopy (VNB) electromagnetic (ENB). Recently, newer technologies—including robotic-assisted (RAB), cone-beam CT (CBCT), augmented fluoroscopy (AF)—have been introduced aid nodules. Technological advances will also enable precise smaller local ablative other therapies cancers future. However, we still need overcome CT-to-body divergence, among In this review, our aim is summarize recent diagnostic technology.

Язык: Английский

---

Overview of malignant central airway obstruction

Mediastinum, Год журнала: 2023, Номер 7, С. 32 - 32

Опубликована: Ноя. 22, 2023

Abstract: Malignant central airway obstruction (MCAO) impacts many patients with advanced primary lung cancers and metastatic disease to the thorax may cause substantial symptoms functional limitations in those affected. Making diagnosis be challenging as are often non-specific but identification is improved a heightened level of suspicion newer thoracic imaging modalities. Bronchoscopy plays crucial role management MCAO therapeutic interventions lifesaving result palliation symptoms. This ultimately improve patient's candidacy receive additional systemic or local cancer therapies potential tumor resection. After initial stabilization, it important that undergo prompt evaluation treatment. Multiple bronchoscopic instruments available for depending on characteristics, location obstruction, viability distal airways, utilized combination during procedures. These modalities include dilation, endobronchial stent placement, thermal non-thermal ablation, mechanical debulking, novel therapies. While these procedures not without risk, there ample evidence showing improvements patient symptoms, quality life, survival following bronchoscopy. review article provides general overview focus interventions.

Язык: Английский

---

Novel diagnostic processes and challenges in bronchoscopy

Pathology & Oncology Research, Год журнала: 2024, Номер 30

Опубликована: Май 21, 2024

Diagnostic bronchoscopy is a minimally invasive procedure that plays crucial role in the diagnosis and management of various respiratory conditions. This paper explores advancements technology have revolutionized field focuses on new diagnostic procedures emerged recent years. These innovative techniques expanded capabilities bronchoscopy, allowing for more accurate comprehensive evaluation will also discuss challenges process with bronchoscope.

Язык: Английский

---

Endobronchial Therapies for Diagnosis, Staging, and Treatment of Lung Cancer

Surgical Clinics of North America, Год журнала: 2022, Номер 102(3), С. 393 - 412

Опубликована: Апрель 21, 2022

Язык: Английский

---

Current diagnosis and treatment of salivary gland-type tumors of the lung

Japanese Journal of Clinical Oncology, Год журнала: 2023, Номер 54(3), С. 229 - 247

Опубликована: Ноя. 28, 2023

Abstract Salivary gland-type tumors of the lung are thought to originate from submucosal exocrine glands large airways. Due their rare occurrence, reports study limited small-scale or case reports. Therefore, daily clinical practices often require a search for previous In last 20 years, several genetic rearrangements have been identified, such as MYB::NF1B in adenoid cystic carcinoma, CRTC1::MAML2 mucoepidermoid EWSR1::ATF1 hyalinizing clear cell carcinoma and EWSR1 locus FUS (TLS) myoepithelioma myoepithelial carcinoma. These molecular alterations useful diagnosing these tumors, although they not yet linked molecularly targeted therapies. The morphologic, immunophenotypic, characteristics similar those counterparts extrapulmonary origin, so radiologic differential diagnosis is required distinguish between primary metastatic disease other sites. However, can be differentiating them cancer histologic types. management requires broad knowledge latest diagnostics, surgery, radiotherapy, bronchoscopic interventions, chemotherapy, immunotherapy well therapeutic agents development, including agents. This review provides comprehensive overview current treatment pulmonary salivary gland with focus on which two most common subtypes.

Язык: Английский

---

Interventional Pulmonology: Diagnostic and Therapeutic Advances in Bronchoscopy

American Journal of Therapeutics, Год журнала: 2021, Номер 28(2), С. e204 - e216

Опубликована: Фев. 9, 2021

Background: Interventional pulmonology is a rapidly evolving subspecialty of pulmonary medicine that offers advanced consultative and procedural services to patients with airway diseases, pleural as well in the diagnosis management thoracic malignancy. Areas Uncertainty: The institution lung cancer screening modalities search additional minimally invasive diagnostic treatment for other chronic diseases has led an increased focus on field interventional pulmonology. Rapid advancements over last 2 decades development various new bronchoscopic approaches techniques diseases. Data Sources: A review literature was performed using PubMed database identify all articles published up till October 2020 relevant bronchoscopy. reference list each article searched look articles, were included article. Therapeutic Advances: Newer technologies are now available such navigation platforms diagnose possibly treat peripheral nodules, endobronchial ultrasound mediastinal hilar adenopathy cryobiopsy diffuse In addition, flexible rigid bronchoscopy continues provide expanding ability manage benign malignant central obstruction. Interventions also asthma, bronchitis, obstructive disease, emphysema traditionally treated medical alone. Conclusions: With continued high quality research increasing body evidence, enormous potential both safe effective options variety

Язык: Английский

---