Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(1), С. 663 - 676
Опубликована: Янв. 11, 2024
This
manuscript
explores
the
role
of
pyroptosis,
an
inflammatory
programmed
cell
death,
in
pathogenesis
two
chronic
dermatoses,
psoriasis
and
hidradenitis
suppurativa
(HS).
The
diseases,
though
clinically
diverse,
share
common
pathogenetic
pathways
involving
unbalanced
interaction
between
adaptive
innate
immune
systems.
review
focuses
on
molecular
changes
psoriatic
HS
skin,
emphasizing
activation
dendritic
cells,
secretion
interleukins
(IL-17,
IL-22,
TNF-α),
involvement
inflammasomes,
particularly
NLRP3.
discusses
caspases,
especially
caspase-1,
driving
pyroptosis
highlights
family
gasdermins
(GSDMs)
as
key
players
formation
pores
leading
to
rupture
release
proinflammatory
signals.
study
delves
into
potential
therapeutic
implications
targeting
HS,
examining
existing
medications
like
biologics
Janus
kinase
inhibitors.
It
also
reviews
current
limitations
challenges
developing
therapies
that
selectively
target
pyroptosis.
Additionally,
various
disorders
associated
with
such
bowel
disease,
diabetes
mellitus,
cardiovascular
disorders.
concludes
by
need
for
further
research
fully
elucidate
pathomechanisms
these
dermatoses
develop
effective,
targeted
therapies.
Medicine in Microecology,
Год журнала:
2024,
Номер
20, С. 100107 - 100107
Опубликована: Апрель 10, 2024
The
microbiota
based
dietary
interventions
have
emerged
as
an
unconventional
bacteriotherapeutic
approach
for
the
treatment
of
a
plethora
pathological
conditions
including
inflammatory
bowel
disease.
potential
side
effects
associated
with
use
probiotics
include
systemic
infections,
deleterious
metabolic
activities,
excessive
immune
stimulation
in
susceptible
individuals
and
gene
transfer.
Moreover,
probiotic
strains
are
not
very
specific
offering
health
benefits
it
is
generally
considered
that
group
such
bacteria
more
effective
than
single
strain.
Based
on
this
assumption,
fecal
matter
transplantation
was
proposed
better
alternative.
Despite
proving
to
be
certain
diseases,
has
found
wide
acceptability
because
its
poor
aesthetic
appeal,
risk
infection
transmission,
challenges
standardization
regulation
policies.
Bacterial
consortia,
however,
emerge
multi-strain,
biotherapeutic
agents
known
composition
free
from
any
infections
or
uncertain
processes.
These
complex
microbial
communities
having
ecological
interactions
among
themselves.
While
therapeutic
profile
similar
transplantation,
bacterial
consortia
effects.
demonstrated
significant
effectiveness
irritable
syndrome.
Inflammatory
disease
represents
multifactorial
ailments
comprising
both
ulcerative
colitis
Crohn's
It
attributed
disturbance
immunological
environmental
factors
while
genetic
also
play
their
role.
Among
all
above,
changes
gut
(dysbiosis)
main
causative
agent
etiology
Therefore,
changing
through
consortium
offers
realistic
option
In
review,
we
decipher
relationship
between
dysbiosis
pathogenesis
We
discuss
various
regarding
therapy.
Diving
deeper,
pre-clinical
clinical
studies
conducted
hitherto
described.
limitations
emerging
discussed.
Considering
worldwide
prevalence
constant
struggle
find
safe,
economical
convenient
cure
it,
could
attractive
strategy.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7310 - 7310
Опубликована: Июль 3, 2024
Metabolites
resulting
from
the
bacterial
fermentation
of
dietary
fibers,
such
as
short-chain
fatty
acids,
especially
butyrate,
play
important
roles
in
maintaining
gut
health
and
regulating
various
biological
effects
skin.
However,
butyrate
is
underutilized
due
to
its
unpleasant
odor.
To
circumvent
this
organoleptic
unfavorable
property,
phenylalanine
butyramide
(PBA),
a
precursor,
has
been
synthesized
currently
available
on
market.
We
evaluated
inhibition
mushroom
tyrosinase
by
PBA
through
vitro
assays,
finding
IC50
values
34.7
mM
120.3
mM,
respectively.
Docking
calculations
using
homology
model
human
identified
putative
binding
mode
into
catalytic
site.
The
anti-aging
anti-spot
efficacy
topical
was
randomized,
double-blind,
parallel-arm,
placebo-controlled
clinical
trial
involving
43
women
affected
photo-damage.
results
study
showed
that
significantly
improved
skin
conditions
compared
placebo
well
tolerated.
Specifically,
demonstrated
strong
depigmenting
activity
both
UV
brown
spots
(UV:
-12.7%
-9.9%,
Bs:
-20.8%
-17.7%
after
15
30
days,
respectively,
p
<
0.001).
Moreover,
brightened
lightened
(ITA°:
+12%
13%
Finally,
elasticity
(Ua/Uf:
+12.4%
+32.3%
0.001)
firmness
(Uf:
-3.2%
-14.9%
0.01).
JDDG Journal der Deutschen Dermatologischen Gesellschaft,
Год журнала:
2023,
Номер
21(4), С. 363 - 373
Опубликована: Апрель 1, 2023
Zusammenfassung
Die
Erforschung
kaum
einer
anderen
Erkrankung
hat
so
grundlegend
neue
Erkenntnisse
über
immunologischen
Regulationen
und
gleichzeitig
eine
derart
rasante
Entwicklung
innovativer
Therapien
hervorgebracht
wie
das
Studium
der
Psoriasis.
In
dieser
kurzen
Übersichtsarbeit
umreißen
wir
die
Grundzüge
aktuellen
Psoriasisforschung
unter
besonderer
Berücksichtigung
pathophysiologischer
Vorgänge
Meilensteine
bei
Zulassung
verschiedener
Biologika
niedermolekularer
Pharmaka.
Nicht
zuletzt
durch
verstehen
Zusammenspiel
Komponenten
des
angeborenen
adaptiven
Immunsystems
immer
besser.
Neue
Therapeutika
greifen
dabei
an
entscheidenden
Punkten
in
regulatorische
Netzwerke
ein.
Ausgehend
vom
derzeitigen
Kenntnisstand
skizzieren
einige
aus
unserer
Sicht
wesentliche
zukünftige
Forschungsrichtungen
sowie
therapeutische
klinische
Entwicklungen
im
Bereich
Diese
reichen
von
genetischer,
epigenetischer,
zellulärer
immunologischer
Mechanismen
Untersuchung
spezifischer
klinischer
Formen
Psoriasis
individueller
systemischer
Auswirkungen
Krankheit
ihrer
Behandlung
bis
hin
zur
Einbeziehung
Big
Data
künstlicher
Intelligenz.
Ziele
sind
ein
ganzheitliches
Verständnis
molekularen
organismischen
gesellschaftlichen
Ebene
darauf
aufbauend
individualisierte
Präventions‐
Behandlungsstrategien.
Trotz
beeindruckender
Fortschritte
muss
sowohl
kleinen
als
auch
großen
Maßstab
weiterentwickelt
werden,
um
den
Bedürfnissen
Behandlern
Patienten
noch
besser
gerecht
zu
werden.
Nutrition Reviews,
Год журнала:
2023,
Номер
82(1), С. 5 - 8
Опубликована: Апрель 17, 2023
Abstract
Context
Most
articles
on
gut
microbiota
argue
the
importance
of
body
composition
assessment
in
patients;
however,
assessments
are
fragile
(ie,
with
methodological
limitations)
most
recent
studies.
Objective
To
present
two
suggestions
for
further
research
using
human
assessment.
Methods
The
methods
used
this
study
based
a
Pinto
et
al
article
published
Nutrition
Reviews.
Data
extraction
On
basis
data
obtained
from
PubMed,
SCOPUS,
LILACS,
and
Web
Science
databases,
provided
current
survey
intermittent
fasting
protocols
an
understanding
outcomes
to
date
terms
profile
intestinal
obese
organisms.
analysis
Of
82
original
identified
35
were
eliminated
because
duplication
32
excluded
not
meeting
inclusion
criteria.
Two
additional
found
new
search
added,
yielding
total
17
studies
be
included
review.
Among
protocols,
alternate-day
time-restricted
feeding
common,
they
shown
have
different
mechanisms
metabolic
signaling.
Time-restricted
influences
mass
control
biochemical
parameters
by
regulating
circadian
system
improving
satiety
systems
acting
leptin
secretion.
In
contrast,
leads
reduction
±75%
all
energy
consumption
regardless
dietary
composition,
addition
promoting
hormonal
adjustments
that
promote
control.
Furthermore,
both
could
remodel
changing
Firmicutes
Bacteroidetes
ratio
increasing
abundance
strains
such
as
Lactobacillus
spp.
Akkermansia
protective
effect
metabolism
against
effects
gain.
Conclusion
Changes
adipose
tissue
(eg,
loss,
control,
gain)
should
interpreted
via
sum
skinfolds
absolute
values,
waist
perimeter,
patients'
proportionality,
fat
is
just
fraction
adipocyte
(lipid).
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(1), С. 663 - 676
Опубликована: Янв. 11, 2024
This
manuscript
explores
the
role
of
pyroptosis,
an
inflammatory
programmed
cell
death,
in
pathogenesis
two
chronic
dermatoses,
psoriasis
and
hidradenitis
suppurativa
(HS).
The
diseases,
though
clinically
diverse,
share
common
pathogenetic
pathways
involving
unbalanced
interaction
between
adaptive
innate
immune
systems.
review
focuses
on
molecular
changes
psoriatic
HS
skin,
emphasizing
activation
dendritic
cells,
secretion
interleukins
(IL-17,
IL-22,
TNF-α),
involvement
inflammasomes,
particularly
NLRP3.
discusses
caspases,
especially
caspase-1,
driving
pyroptosis
highlights
family
gasdermins
(GSDMs)
as
key
players
formation
pores
leading
to
rupture
release
proinflammatory
signals.
study
delves
into
potential
therapeutic
implications
targeting
HS,
examining
existing
medications
like
biologics
Janus
kinase
inhibitors.
It
also
reviews
current
limitations
challenges
developing
therapies
that
selectively
target
pyroptosis.
Additionally,
various
disorders
associated
with
such
bowel
disease,
diabetes
mellitus,
cardiovascular
disorders.
concludes
by
need
for
further
research
fully
elucidate
pathomechanisms
these
dermatoses
develop
effective,
targeted
therapies.
