Allergologia et Immunopathologia,
Journal Year:
2023,
Volume and Issue:
51(1), P. 140 - 145
Published: Jan. 1, 2023
Objective:
To
unravel
the
role
of
La
ribonucleoprotein
7
(LARP7),
a
transcriptional
regulator,
in
progression
psoriasis
and
underlying
molecular
mechanisms.
Methods:
The
psoriasis-like
mice
model
was
created
by
daily
administering
imiquimod
on
shaved
skin.
histological
analysis
skin
damage
were
evaluated
each
group.
inflammation
oxidative
stress
response
assessed
enzyme-linked-immunosorbent
serologic
immunoblot
assays.
involvement
silent
information
regulator
1
(mem-ber
Sirtuin
family;
SIRT1/nuclear
factor
kappa
B
(NF-κB)
signaling
pathway
LARP7-mediated
also
detected
assay.
Results:
LARP7
relieved
symptoms
model.
inhibited
expression
inflammatory
cytokines
as
well
chemokines
tissues.
Additionally,
suppressed
tissues
mice.
activation
SIRT1/NF-κB
pathway,
therefore
affected
psoriasis.
Conclusion:
regulating
pathway.
Nutrition Reviews,
Journal Year:
2023,
Volume and Issue:
82(1), P. 5 - 8
Published: April 17, 2023
Abstract
Context
Most
articles
on
gut
microbiota
argue
the
importance
of
body
composition
assessment
in
patients;
however,
assessments
are
fragile
(ie,
with
methodological
limitations)
most
recent
studies.
Objective
To
present
two
suggestions
for
further
research
using
human
assessment.
Methods
The
methods
used
this
study
based
a
Pinto
et
al
article
published
Nutrition
Reviews.
Data
extraction
On
basis
data
obtained
from
PubMed,
SCOPUS,
LILACS,
and
Web
Science
databases,
provided
current
survey
intermittent
fasting
protocols
an
understanding
outcomes
to
date
terms
profile
intestinal
obese
organisms.
analysis
Of
82
original
identified
35
were
eliminated
because
duplication
32
excluded
not
meeting
inclusion
criteria.
Two
additional
found
new
search
added,
yielding
total
17
studies
be
included
review.
Among
protocols,
alternate-day
time-restricted
feeding
common,
they
shown
have
different
mechanisms
metabolic
signaling.
Time-restricted
influences
mass
control
biochemical
parameters
by
regulating
circadian
system
improving
satiety
systems
acting
leptin
secretion.
In
contrast,
leads
reduction
±75%
all
energy
consumption
regardless
dietary
composition,
addition
promoting
hormonal
adjustments
that
promote
control.
Furthermore,
both
could
remodel
changing
Firmicutes
Bacteroidetes
ratio
increasing
abundance
strains
such
as
Lactobacillus
spp.
Akkermansia
protective
effect
metabolism
against
effects
gain.
Conclusion
Changes
adipose
tissue
(eg,
loss,
control,
gain)
should
interpreted
via
sum
skinfolds
absolute
values,
waist
perimeter,
patients'
proportionality,
fat
is
just
fraction
adipocyte
(lipid).
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(1), P. 663 - 676
Published: Jan. 11, 2024
This
manuscript
explores
the
role
of
pyroptosis,
an
inflammatory
programmed
cell
death,
in
pathogenesis
two
chronic
dermatoses,
psoriasis
and
hidradenitis
suppurativa
(HS).
The
diseases,
though
clinically
diverse,
share
common
pathogenetic
pathways
involving
unbalanced
interaction
between
adaptive
innate
immune
systems.
review
focuses
on
molecular
changes
psoriatic
HS
skin,
emphasizing
activation
dendritic
cells,
secretion
interleukins
(IL-17,
IL-22,
TNF-α),
involvement
inflammasomes,
particularly
NLRP3.
discusses
caspases,
especially
caspase-1,
driving
pyroptosis
highlights
family
gasdermins
(GSDMs)
as
key
players
formation
pores
leading
to
rupture
release
proinflammatory
signals.
study
delves
into
potential
therapeutic
implications
targeting
HS,
examining
existing
medications
like
biologics
Janus
kinase
inhibitors.
It
also
reviews
current
limitations
challenges
developing
therapies
that
selectively
target
pyroptosis.
Additionally,
various
disorders
associated
with
such
bowel
disease,
diabetes
mellitus,
cardiovascular
disorders.
concludes
by
need
for
further
research
fully
elucidate
pathomechanisms
these
dermatoses
develop
effective,
targeted
therapies.
Medicine in Microecology,
Journal Year:
2024,
Volume and Issue:
21, P. 100109 - 100109
Published: July 22, 2024
Striae
distensae
(SD),
commonly
known
as
Stretch
marks
or
striae,
are
one
of
the
most
common
benign
dermal
lesions
frequently
seen
in
females
that
often
cause
a
significant
physical
and
psychological
impact.
A
number
treatment
modalities
ranging
from
topicals
to
invasive
approaches
commercially
available,
however,
none
available
options
is
capable
complete
eradication
SD.
As
effectiveness
topical
formulations
for
SD
attributed
combined
effects
their
antioxidant,
anti-inflammatory
proliferative
effects,
allicin
probiotic
based
hypothesized
be
effective
prevention
Both
probiotics
able
reduce
inflammatory
response
via
suppression
transcription
factor
i.e.,
nuclear
(NF)-κB,
pro-inflammatory
cytokines
chemokines
levels.
Moreover,
antioxidant
effect
considered
decrease
reactive
oxygen
species
induced
fragmentation
collagen.
Also,
on
collagen
elastin
tissue
well
beneficial
metabolites
skin
elasticity
hydration
expected
provide
multiple
target
approach
management
Altogether,
combination
formulation
containing
both
novel
Allergologia et Immunopathologia,
Journal Year:
2023,
Volume and Issue:
51(1), P. 140 - 145
Published: Jan. 1, 2023
Objective:
To
unravel
the
role
of
La
ribonucleoprotein
7
(LARP7),
a
transcriptional
regulator,
in
progression
psoriasis
and
underlying
molecular
mechanisms.
Methods:
The
psoriasis-like
mice
model
was
created
by
daily
administering
imiquimod
on
shaved
skin.
histological
analysis
skin
damage
were
evaluated
each
group.
inflammation
oxidative
stress
response
assessed
enzyme-linked-immunosorbent
serologic
immunoblot
assays.
involvement
silent
information
regulator
1
(mem-ber
Sirtuin
family;
SIRT1/nuclear
factor
kappa
B
(NF-κB)
signaling
pathway
LARP7-mediated
also
detected
assay.
Results:
LARP7
relieved
symptoms
model.
inhibited
expression
inflammatory
cytokines
as
well
chemokines
tissues.
Additionally,
suppressed
tissues
mice.
activation
SIRT1/NF-κB
pathway,
therefore
affected
psoriasis.
Conclusion:
regulating
pathway.
