Energy metabolism in health and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 18, 2025

Язык: Английский

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The effects of intermittent fasting for patients with multiple sclerosis (MS): a systematic review

Frontiers in Nutrition, Год журнала: 2024, Номер 10

Опубликована: Янв. 17, 2024

Some studies have investigated the impact of intermittent fasting (IF) for patients with multiple sclerosis (MS). We aimed to conduct a comprehensive systematic review analyze and summarize all clinical concerning effects IF on MS. conducted an exhaustive information available in Embase, Cochrane, PubMed databases up until 1 September 2023. All research relating impacts MS were included. In total, this encompassed 5 studies, which included four RCTs one pilot study. Each study involved was assessed high quality. The results from these demonstrate that protocols could potentially serve as effective dietary strategy managing symptoms improving quality life individuals afflicted conclusion, might be potential beneficial intervention However, number trials field is relatively limited. large-scale investigate are urgently needed, may helpful manage intricate neuroimmune disorder. Systematic registration https://inplasy.com , identifier INPLASY2023100021.

Язык: Английский

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Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective

Nutrition Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 23, 2025

Ulcerative colitis (UC) has experienced a steady increase in global incidence and prevalence recently. Current research into UC pathogenesis focuses on the complex interplay of genetic environmental factors with immune system gut microbiome, leading to disruption intestinal barrier. Normally, epithelium, interact maintain homeostasis. However, when this equilibrium is disturbed, harmful cycle dysbiosis, dysregulation, inflammation emerges, resulting barrier dysfunction progression. Among various risk factors, diet significantly influences epithelial integrity architectural stability through both direct indirect mechanisms, shaping entire continuum from pre-clinical prevention active phase treatment remission maintenance. This review provides insights impact dietary content eating behaviors UC, focusing specific food, food groups, nutrients, intermittent fasting, while providing detailed explanation why microbiota may mediate sustained effects across all stages UC. Additionally, it addresses limitations current studies, explores underexamined areas proposes potential directions for future expansion. Not applicable.

Язык: Английский

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Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen Approach

Foods, Год журнала: 2024, Номер 13(13), С. 1960 - 1960

Опубликована: Июнь 21, 2024

Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications, such metabolic syndrome type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day (ADF) or time-restricted feeding (TRF), was compared with approach. We evaluated different roles of IF treating human disorders syndrome, diabetes, some types cancer, well usefulness reducing cardiovascular risk factors hypertension. Furthermore, explored cellular pathways targeted exert their beneficial effects activating effector proteins that modulate cell functions resistance oxidative stress. contrast, investigated concerns regarding health related adoption regimens, highlighting profound debate surrounding loss regimens. examined several trials formulate an updated concept its therapeutic potential.

Язык: Английский

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Intermittent Fasting on Neurologic Diseases: Potential Role of Gut Microbiota

Nutrients, Год журнала: 2023, Номер 15(23), С. 4915 - 4915

Опубликована: Ноя. 24, 2023

As the global population ages, prevalence of neurodegenerative diseases is surging. These disorders have a multifaceted pathogenesis, entwined with genetic and environmental factors. Emerging research underscores profound influence diet on development progression health conditions. Intermittent fasting (IF), dietary pattern that increasingly embraced recommended, has demonstrated potential in improving neurophysiological functions mitigating pathological injuries few adverse effects. Although precise mechanisms IF’s beneficial impact are not yet completely understood, gut microbiota their metabolites believed to be pivotal mediating these This review endeavors thoroughly examine current studies shifts metabolite profiles prompted by IF, possible consequences for neural health. It also highlights significance strategies as clinical consideration those neurological

Язык: Английский

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Fasting and Autophagy and Its Effect on Health

IntechOpen eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Intermittent fasting, a cleansing activity that severely restricts calorie intake, is an effective means of activating autophagy. As dietary pattern, intermittent fasting can delay aging and reduce the risk age-related diseases. helps maintain homeostasis body through series hormonal metabolic changes, protecting variety diseases preventing chronic And it has been shown to improve efficacy weight loss obesity-related non-alcoholic fatty liver disease health indicators. There are still some challenges in area fasting’s effects, further long-term clinical studies needed.

Язык: Английский

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Time-restricted feeding alleviates arthritis symptoms augmented by high-fat diet

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 13, 2025

Rheumatoid arthritis (RA) affects approximately 1% of the global population. Its hallmark symptoms include severe pain and joint stiffness, which significantly diminish life quality. RA’s development is influenced by multiple factors including unhealthy lifestyle habits. Calorie-rich diets, particularly those high in fat resulting obesity, are associated with RA exacerbate its symptoms. Consequently, dietary modifications recommended as a complementary treatment. However, adherence often low due to restrictive changes required nutrient composition or caloric intake. Our previous findings indicate that time-restricted feeding (TRF) benefits leukocyte rhythm mitigates autoimmune responses. In this study we explored impact TRF on severity K/BxN serum-transfer (STA) mice subjected high-fat diet. Three schedules were implemented: control (Ctrl) constant access standard chow, diet group (HF) ad libitum food access, (HF-TRF) 10-hour window during active phase. After four weeks conditioning, STA was induced. Although macroscopic markers inflammation did not differ between Ctrl HF groups, histological analysis revealed increased mice, expanded edema, pannus formation, bone erosion, elevated synovial neutrophil infiltration serum leptin levels. Importantly, all these inflammatory reduced HF-TRF group, along IL-1β monocyte/macrophage counts. results can severity, potentially serving preventive method sustainable therapeutic support for management.

Язык: Английский

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A multicenter mixed-methods study on the effects of intermittent fasting in patients with immune thrombocytopenia receiving thrombopoietin receptor agonists

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 26, 2025

Introduction In recent years, significant advances have been made in the treatment of immune thrombocytopenia (ITP) with development thrombopoietin receptor agonists (TPO-RAs). TPO-RAs are often used following failure prior therapies or when bleeding episodes persist despite glucocorticoid use. Muslim countries, where religious observance includes 16/8 intermittent fasting, timing medication administration may be affected. This study is first to evaluate impact Ramadan fasting on patients receiving different TPO-RAs. Methods A multicenter mixed-design was performed which who fasted during while were interviewed between 2015 and 2023. Patient responses before, during, after evaluated retrospectively. The tendency assessed as (1) no bleeding, (2) minor cutaneous/mucosal (3) severe that involves major organs. Results present included 100 from three including Qatar, Kuwait, Saudi Arabia, across four tertiary centers. complete response observed 63% ROM, 46% ELT 37% AVA. For AVA, mean platelet (PLT) count before estimated at [146.11 ± 111.76], Ramadan, it dropped [131.7 107.6]. ELT, PLT [120.02 59.7], [100.8 68.16] ( p = 0.016). [122.68 80.57], [130.94 84.96]. Only 3% (3 ELT) experienced episodes. Conclusion supports feasibility for ITP Further studies a larger sample size recommended investigate other types efficacy safety

Язык: Английский

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Efficacy of Intermittent Fasting in the Management of Chronic Plaque Psoriasis: A Phase IIb Clinical Trial

Indian Dermatology Online Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Abstract Background: Dietary measures have been used as an adjunctive therapy in the management of psoriasis. Intermittent fasting (IF) is eating pattern which energy not consumed for a fixed duration, resulting metabolic switch from liver-derived glucose to adipose-derived ketones. The data regarding effectiveness IF psoriasis are limited. Aim and Objectives: aim this study was assess efficacy patients with chronic plaque primary outcome change severity measured by area index (PASI) at 28 weeks. secondary were parameters biomarkers atherosclerosis each group. Patients Methods: designed randomized parallel group trial. Clinical parameters, severity, postprandial blood sugar, lipid profile, high sensitivity C-reactive protein (hsCRP), vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), using standard methods baseline, 16 weeks, receive methotrexate dose 0.3 mg/Kg/week or without intermittent fasting. Results: A total 120 two groups 60 each: 1 (methotrexate) 2 (methotrexate fasting). mean age, duration disease, PASI, dermatology life quality (DLQI) 45.5 (±12.9) years, 5.06 (±5.5) 17.1 (±6.7), 12.33 (±5), respectively. DLQI 42.9 (±14.6) 6.91 (±6.2) (±4.3), 11.9 There no statistically significant difference baseline groups. In both groups, there DLQI, VEGF, hsCRP At week 16, 44 (73.3%) 47 (78.3%) achieved PASI50 ( P = 0.8). 28, (36%) 27 (54.4%) maintained 0.054). weight waist circumference reduction weeks 2. IL6, compared 1. Limitations: small sample size loss follow-up major limitations study. Conclusion: 16: 8 protocol easy perform safe effective adjuvant managing severe It helps maintaining remission results improvement markers inflammation.

Язык: Английский

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A Multi-omics approach to identify and validate shared genetic architecture in rheumatoid arthritis, multiple sclerosis, and type 1 diabetes: integrating GWAS, GEO, MSigDB, and scRNA-seq data

Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 21, 2025

Язык: Английский

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