Опубликована: Ноя. 20, 2024
Язык: Английский
Selective head-and-neck cooling on biomarker levels and symptom rating following a boxing bout- protocol for an exploratory randomized trial (Preprint)
OBJECTIVE
We
hypothesized
acute
head-and-neck
cooling,
recently
shown
shorten
return-to-play
concussed
ice
hockey
players,
applied
acutely
following
a
bout
is
associated
with
an
attenuated
release
biomarkers
improved
symptom
rating.
METHODS
The
trial
academically
driven
funded
external
hospital
research
funds.
Young,
healthy
elite
boxers
≥
18
years
old
recruited.
Prior
to,
immediately
after
competitive
over
3x2
or
3x3
minutes,
samples
drawn.
Boxers
randomized
intervention
control
management
1:1
allocation
prior
baseline
testing.
After
initial
post-fight
sample
drawn
rating
using
concussion
assessment
tool-5
(SCAT-5)
has
been
collected,
receive
either
selective
cooling
for
45
min,
routine
management.
number
head
counted
all
on
match
video
recordings.
In
both
groups,
minutes
post-bout
sample,
well
3
6
days
post-fight.
At
time
points
sampling,
symptoms
(NOS)
severity
score
(SSS)
assessed
part
SCAT-5.
RESULTS
primary
endpoint
difference
biomarker
levels
(GFAP,
NF-L,
tau,
UCH-L1,
neuronal-specific
enolase)
between
pre-intervention
levels,
those
obtained
SCAT-5
NOS
SSS
secondary
endpoints.
CONCLUSIONS
There
no
treatment
available
boxing-induced
injury.
Biomarkers
surrogate
yet
objective
marker
injury,
attenuate
injury-related
reduce
attained
during
fight.
Potentially,
option
bout.
CLINICALTRIAL
ClinicalTrials.gov,
ClinicalTrials.gov
Identifier
NCT06386484.
Registered
April
23,
2024.
