
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Авг. 6, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Авг. 6, 2024
Язык: Английский
Neurotherapeutics, Год журнала: 2025, Номер 22(1), С. e00521 - e00521
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Applied Spectroscopy Reviews, Год журнала: 2025, Номер unknown, С. 1 - 30
Опубликована: Апрель 4, 2025
Язык: Английский
Процитировано
1The Lancet Neurology, Год журнала: 2025, Номер 24(6), С. 512 - 523
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
1Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Окт. 25, 2024
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage plays a critical role in neurodegenerative diseases. Though the exact mechanism disease pathogenesis is not understood, certain biomarkers provide valuable insight into pathogenesis, severity, progression therapeutic efficacy. These markers can be used to assess pathophysiological status brain including neurons, astrocytes, microglia, oligodendrocytes, specialized microvascular endothelial cells, pericytes, NVU, blood-brain barrier (BBB) disruption. Damage or derangements tight junction (TJ), adherens (AdJ), gap (GJ) components BBB lead increased permeability neuroinflammation various disorders disorders. Thus, neuroinflammatory evaluated blood, cerebrospinal fluid (CSF), tissues determine neurological progression, responsiveness. Chronic common age-related Alzheimer's (AD), Parkinson's (PD), dementia. Neurotrauma/traumatic injury (TBI) also leads acute chronic responses. The expression some may altered many years even decades before onset In this review, we discuss neuroinflammation, neurodegeneration associated with disorders, especially those neurovascular pathologies. CSF, tissues. Neurofilament light (NfL), ubiquitin C-terminal hydrolase-L1 (UCHL1), fibrillary acidic protein (GFAP), Ionized calcium-binding adaptor molecule 1 (Iba-1), transmembrane 119 (TMEM119), aquaporin, endothelin-1, platelet-derived growth factor receptor beta (PDGFRβ) are important markers. Recent BBB-on-a-chip modeling offers promising potential for providing an in-depth understanding neurotherapeutics. Integration these clinical practice could potentially enhance early diagnosis, monitor improve outcomes.
Язык: Английский
Процитировано
7Clinical Neurology and Neurosurgery, Год журнала: 2024, Номер 242, С. 108312 - 108312
Опубликована: Апрель 30, 2024
Язык: Английский
Процитировано
6Nature Reviews Neurology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
5Nanotechnology, Год журнала: 2025, Номер 36(13), С. 135101 - 135101
Опубликована: Янв. 14, 2025
Accurate and rapid diagnosis of traumatic brain injury (TBI) is very important for high quality medical services. Nonetheless, the current diagnostic platform still has challenges in accurate analysis clinical samples. Here, we prepared a highly stable, repeatable sensitive gold-plated silver core-shell nanowire (Ag@AuNWs) surface-enhanced Raman spectroscopy (SERS) metabolic fingerprint TBI. The structure significantly enhanced SERS intensity enables direct detection 10μl serum within seconds. principal component analysis-linear discriminant (PCA-LDA) partial least squares-DA (PLS-DA) are used to evaluate classification effect this technology on TBI, respectively. accuracy rate PCA-LDA PLS-DA 73.3% 86.7% diagnosing Consequently, model optimal selection distinguishing between TBI sham groups. This research will facilitate application-oriented creation novel materials with tailored structural designs formulation innovative precision protocols imminent future.
Язык: Английский
Процитировано
0Measurement, Год журнала: 2025, Номер unknown, С. 117279 - 117279
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0Diagnostics, Год журнала: 2025, Номер 15(5), С. 648 - 648
Опубликована: Март 6, 2025
In a rapidly changing technology landscape, “Clinical Decision Support” (CDS) has become an important tool to improve patient management. CDS systems offer medical professionals new insights diagnostic accuracy, therapy planning, and personalized treatment. addition, provide cost-effective options augment conventional screening for secondary prevention. This review aims (i) describe the purpose mechanisms of systems, (ii) discuss different entities algorithms, (iii) highlight quality features, (iv) challenges limitations in clinical practice. Furthermore, we (v) contemporary algorithms oncology, acute care, cardiology, nephrology. particular, consolidate research on across diseases that imply significant disease economic burden, such as lung cancer, colorectal hepatocellular coronary artery disease, traumatic brain injury, sepsis, chronic kidney disease.
Язык: Английский
Процитировано
0Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113408 - 113408
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
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