Selective head-and-neck cooling on biomarker levels and symptom rating following a boxing bout- protocol for an exploratory randomized trial
Abstract
Background
Head
impacts
are
common
in
contact
sports
such
as
boxing
and
occur
at
times
of
elevated
core
body
brain
temperatures
induced
by
the
exercise.
Following
impact,
temperature
may
lead
to
development
exacerbated
injury
that
can
be
monitored
blood
biomarkers.
We
hypothesized
acute
head-and-neck
cooling,
recently
shown
shorten
return-to-play
concussed
ice
hockey
players,
applied
acutely
following
a
bout
is
associated
with
an
attenuated
release
biomarkers
improved
symptom
rating.
Methods
The
trial
academically
driven
funded
external
hospital
research
funds.
Young,
healthy
elite
boxers
≥
18
years
old
recruited.
Prior
to,
immediately
after
competitive
over
3x2
or
3x3
minutes,
samples
drawn.
Boxers
randomized
intervention
control
management
1:1
allocation
prior
baseline
testing.
After
initial
post-fight
sample
drawn
rating
using
concussion
assessment
tool-5
(SCAT-5)
has
been
collected,
receive
either
selective
cooling
for
45
min,
routine
management.
number
head
counted
all
on
match
video
recordings.
In
both
groups,
minutes
post-bout
sample,
well
3
6
days
post-fight.
At
time
points
sampling,
symptoms
(NOS)
severity
score
(SSS)
assessed
part
SCAT-5.
primary
endpoint
difference
biomarker
levels
(GFAP,
NF-L,
tau,
UCH-L1,
neuronal-specific
enolase)
between
pre-intervention
levels,
those
obtained
SCAT-5
NOS
SSS
secondary
endpoints.
Discussion
There
no
treatment
available
boxing-induced
injury.
Biomarkers
surrogate
yet
objective
marker
injury,
attenuate
injury-related
reduce
attained
during
fight.
Potentially,
option
bout.
Trials
registration
ClinicalTrials.gov,
ClinicalTrials.gov
Identifier
NCT06386484.
Registered
April
23,
2024.
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Авг. 6, 2024
Язык: Английский