Selective head-and-neck cooling on biomarker levels and symptom rating following a boxing bout- protocol for an exploratory randomized trial DOI Creative Commons
Ali Al-Husseini, Yelverton Tegner, Kaj Blennow

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Abstract Background Head impacts are common in contact sports such as boxing and occur at times of elevated core body brain temperatures induced by the exercise. Following impact, temperature may lead to development exacerbated injury that can be monitored blood biomarkers. We hypothesized acute head-and-neck cooling, recently shown shorten return-to-play concussed ice hockey players, applied acutely following a bout is associated with an attenuated release biomarkers improved symptom rating. Methods The trial academically driven funded external hospital research funds. Young, healthy elite boxers ≥ 18 years old recruited. Prior to, immediately after competitive over 3x2 or 3x3 minutes, samples drawn. Boxers randomized intervention control management 1:1 allocation prior baseline testing. After initial post-fight sample drawn rating using concussion assessment tool-5 (SCAT-5) has been collected, receive either selective cooling for 45 min, routine management. number head counted all on match video recordings. In both groups, minutes post-bout sample, well 3 6 days post-fight. At time points sampling, symptoms (NOS) severity score (SSS) assessed part SCAT-5. primary endpoint difference biomarker levels (GFAP, NF-L, tau, UCH-L1, neuronal-specific enolase) between pre-intervention levels, those obtained SCAT-5 NOS SSS secondary endpoints. Discussion There no treatment available boxing-induced injury. Biomarkers surrogate yet objective marker injury, attenuate injury-related reduce attained during fight. Potentially, option bout. Trials registration ClinicalTrials.gov, ClinicalTrials.gov Identifier NCT06386484. Registered April 23, 2024.

Язык: Английский

Plasma brain-related biomarkers and potential therapeutic targets in pediatric ECMO DOI Creative Commons
Sue J. Hong,

Bradley J. De Souza,

Kristen K. Penberthy

и другие.

Neurotherapeutics, Год журнала: 2025, Номер 22(1), С. e00521 - e00521

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Advances in spectroscopic detection of traumatic brain injury biomarkers: Potential for diagnostic applications DOI
Yowhan Son,

Moon‐Young Jeong,

Jong Min Lim

и другие.

Applied Spectroscopy Reviews, Год журнала: 2025, Номер unknown, С. 1 - 30

Опубликована: Апрель 4, 2025

Язык: Английский

Процитировано

1

A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative DOI

Geoffrey T. Manley,

Kristen Dams-O'Connor,

Michael L. Alosco

и другие.

The Lancet Neurology, Год журнала: 2025, Номер 24(6), С. 512 - 523

Опубликована: Май 20, 2025

Язык: Английский

Процитировано

1

Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders DOI Creative Commons
Duraisamy Kempuraj,

Kirk D. Dourvetakis,

Jessica R. Cohen

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 25, 2024

Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage plays a critical role in neurodegenerative diseases. Though the exact mechanism disease pathogenesis is not understood, certain biomarkers provide valuable insight into pathogenesis, severity, progression therapeutic efficacy. These markers can be used to assess pathophysiological status brain including neurons, astrocytes, microglia, oligodendrocytes, specialized microvascular endothelial cells, pericytes, NVU, blood-brain barrier (BBB) disruption. Damage or derangements tight junction (TJ), adherens (AdJ), gap (GJ) components BBB lead increased permeability neuroinflammation various disorders disorders. Thus, neuroinflammatory evaluated blood, cerebrospinal fluid (CSF), tissues determine neurological progression, responsiveness. Chronic common age-related Alzheimer's (AD), Parkinson's (PD), dementia. Neurotrauma/traumatic injury (TBI) also leads acute chronic responses. The expression some may altered many years even decades before onset In this review, we discuss neuroinflammation, neurodegeneration associated with disorders, especially those neurovascular pathologies. CSF, tissues. Neurofilament light (NfL), ubiquitin C-terminal hydrolase-L1 (UCHL1), fibrillary acidic protein (GFAP), Ionized calcium-binding adaptor molecule 1 (Iba-1), transmembrane 119 (TMEM119), aquaporin, endothelin-1, platelet-derived growth factor receptor beta (PDGFRβ) are important markers. Recent BBB-on-a-chip modeling offers promising potential for providing an in-depth understanding neurotherapeutics. Integration these clinical practice could potentially enhance early diagnosis, monitor improve outcomes.

Язык: Английский

Процитировано

7

A Systematic Review and Meta-Analysis of Major Blood Protein Biomarkers that Predict Unfavorable Outcomes in Severe Traumatic Brain Injury DOI
Faraz Behzadi, Diego D. Luy,

Peter Schaible

и другие.

Clinical Neurology and Neurosurgery, Год журнала: 2024, Номер 242, С. 108312 - 108312

Опубликована: Апрель 30, 2024

Язык: Английский

Процитировано

6

Fluid biomarkers of chronic traumatic brain injury DOI

Susanna Friberg,

Caroline Lindblad, Frederick A. Zeiler

и другие.

Nature Reviews Neurology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Язык: Английский

Процитировано

5

Serum metabolic fingerprinting on Ag@AuNWs for traumatic brain injury diagnosis DOI

Jing-Ling Qiang,

Yanling Liu, Jian Zhu

и другие.

Nanotechnology, Год журнала: 2025, Номер 36(13), С. 135101 - 135101

Опубликована: Янв. 14, 2025

Accurate and rapid diagnosis of traumatic brain injury (TBI) is very important for high quality medical services. Nonetheless, the current diagnostic platform still has challenges in accurate analysis clinical samples. Here, we prepared a highly stable, repeatable sensitive gold-plated silver core-shell nanowire (Ag@AuNWs) surface-enhanced Raman spectroscopy (SERS) metabolic fingerprint TBI. The structure significantly enhanced SERS intensity enables direct detection 10μl serum within seconds. principal component analysis-linear discriminant (PCA-LDA) partial least squares-DA (PLS-DA) are used to evaluate classification effect this technology on TBI, respectively. accuracy rate PCA-LDA PLS-DA 73.3% 86.7% diagnosing Consequently, model optimal selection distinguishing between TBI sham groups. This research will facilitate application-oriented creation novel materials with tailored structural designs formulation innovative precision protocols imminent future.

Язык: Английский

Процитировано

0

Insights into computer-aided EEG signal processing for traumatic brain injury assessment: A review DOI

Farzaneh Manzari,

Peyvand Ghaderyan

Measurement, Год журнала: 2025, Номер unknown, С. 117279 - 117279

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

The Value of Clinical Decision Support in Healthcare: A Focus on Screening and Early Detection DOI Creative Commons
Hendrik Schäfer,

Nesrine Lajmi,

P. Valente

и другие.

Diagnostics, Год журнала: 2025, Номер 15(5), С. 648 - 648

Опубликована: Март 6, 2025

In a rapidly changing technology landscape, “Clinical Decision Support” (CDS) has become an important tool to improve patient management. CDS systems offer medical professionals new insights diagnostic accuracy, therapy planning, and personalized treatment. addition, provide cost-effective options augment conventional screening for secondary prevention. This review aims (i) describe the purpose mechanisms of systems, (ii) discuss different entities algorithms, (iii) highlight quality features, (iv) challenges limitations in clinical practice. Furthermore, we (v) contemporary algorithms oncology, acute care, cardiology, nephrology. particular, consolidate research on across diseases that imply significant disease economic burden, such as lung cancer, colorectal hepatocellular coronary artery disease, traumatic brain injury, sepsis, chronic kidney disease.

Язык: Английский

Процитировано

0

A novel and mass-sensitive quartz tuning fork platform for glial fibrillary acidic protein determination DOI
Burcu Özcan, İnci Uludağ, Mehmet Altay Ünal

и другие.

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113408 - 113408

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0