TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 181, С. 118030 - 118030
Опубликована: Окт. 29, 2024
Язык: Английский
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Combination therapy, which involves using multiple therapeutic modalities simultaneously or sequentially, has become a cornerstone of modern cancer treatment. Graphene-based nanomaterials (GBNs) have emerged as versatile platforms for drug delivery, gene and photothermal therapy. These materials enable synergistic approach, improving the efficacy treatments while reducing side effects. This review explores roles graphene, graphene oxide (GO), quantum dots (GQDs) in combination therapies highlights their potential to enhance immunotherapy targeted therapies. The large surface area high drug-loading capacity facilitate codelivery agents, promoting sustained release. GQDs, with unique optical properties, offer real-time imaging capabilities, adding another layer precision However, challenges such biocompatibility, long-term toxicity, scalability need be addressed ensure clinical safety. Preclinical studies show promising results GBNs, suggesting revolutionize treatment through innovative
Язык: Английский
Процитировано
2
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Год журнала: 2024, Номер 157, С. 106661 - 106661
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
9
Advanced NanoBiomed Research, Год журнала: 2023, Номер 3(9)
Опубликована: Авг. 3, 2023
Diverse applications of nanoparticles (NP) have been revolutionary for various industrial sectors worldwide. In particular, magnetic (MNP) gained great interest because their in specialized medical areas. This review starts with a brief overview the behavior MNP and short description most used synthesis methods. The second part is dedicated to tissue engineering, emphasizing calcium phosphate‐based NP intrinsic properties, recently highlighted literature as alternative viable solutions bone regeneration. challenges associated controversial long‐term toxicity effects can be overcome using this new generation multifunctional bone‐like materials. Furthermore, influence field parameters, such modality application, intensity, spatial distribution, on biological materials, especially repair, shown. last presents current state art regarding development biomaterials additive manufacturing (AM), aiming fabricate scaffolds by AM technologies, focusing engineering applications.
Язык: Английский
Процитировано
15
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Сен. 14, 2023
Abstract This study aimed to evaluate the efficacy of calcium carbonate nanoparticles (CCNPs) induce new bone formation in a critical size segmental defect rabbit’s radius when used alone, combined with silver (AgNPs) as paste, or composite containing CCNPs, AgNPs, and advanced platelet-rich fibrin (A-PRF). Thirty-six adult apparently healthy male New Zealand White rabbits aging from 5 6 months weighting 3.5 ± 0.5 kg were used. The animals divided into four groups; control group, CCNPs CCNPs/AgNPs paste CCNPs/AgNPs/A-PRF group. investigated at 4, 8, 12 weeks post-implantation which healing was evaluated using computed tomographic (CT) histopathological evaluation. results revealed that has superior effect regarding amount quality newly formed compared alone. In conclusion, addition AgNPs and/or A-PRF reduced its resorption rate improved osteogenic osteoinductive properties.
Язык: Английский
Процитировано
15
Pharmaceutics, Год журнала: 2024, Номер 16(1), С. 88 - 88
Опубликована: Янв. 9, 2024
Clinical drug administration aims to deliver drugs efficiently and safely target tissues, organs, cells, with the objective of enabling their therapeutic effects. Currently, main approach enhance a drug’s effectiveness is ensuring its efficient delivery intended site. Due fact that there are still various drawbacks traditional methods, such as high toxicity side effects, insufficient specificity, poor targeting, pharmacokinetic performance, nanocarriers have emerged promising alternative. Nanocarriers possess significant advantages in due size tunability surface modifiability. Moreover, nano-drug systems demonstrated strong potential terms prolonging circulation time, improving bioavailability, increasing retention at tumor site, decreasing resistance, well reducing undesirable effects anticancer drugs. Numerous studies focused on utilizing polysaccharides nanodelivery carriers, developing based polysaccharides, or exploiting tumor-targeting ligands precision nanoparticle delivery. These types investigations become commonplace academic literature. This review elucidate preparation methods principles polysaccharide gold nanocarriers. It also provides an overview factors affect loading different kinds Additionally, it outlines strategies employed by improve efficiency The provide reference for further development research systems.
Язык: Английский
Процитировано
5
Polymers, Год журнала: 2024, Номер 16(3), С. 405 - 405
Опубликована: Фев. 1, 2024
Liposomes show promise for anti-cancer drug delivery and tumor-targeted therapy. However, complex tumor microenvironments the performance limitations of traditional liposomes restrict clinical translation. Hyaluronic acid (HA)-modified nanoliposomes effectively target CD44-overexpressing cells. Combination therapy enhances treatment efficacy delays resistance. Here, we developed paclitaxel (PTX) co-modified with ginsenoside compound K (CK) HA using film dispersion. Compared to cholesterol (Ch), CK substantially improved encapsulation efficiency stability. In vitro release studies revealed pH-responsive behavior, slower at pH 7.4 versus faster 5. cytotoxicity assays demonstrated that replacing Ch in modified considerably decreased HCT-116 cell viability. Furthermore, flow cytometry fluorescence microscopy showed a higher cellular uptake PTX-CK-Lip-HA CD44-high cells, reflected lower half maximal inhibitory concentrations. Overall, CK/HA-modified represent an innovative, targeted system enhanced via pH-triggered CD44 binding.
Язык: Английский
Процитировано
4
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 288, С. 117427 - 117427
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101607 - 101607
Опубликована: Март 5, 2025
Osteosarcoma (OS) is the most prevalent malignant primary bone tumor, predominantly affecting children and young adults between ages of 11 20. OS presents huge challenges in treatment because its aggressive nature high metastatic potential. Chemotherapeutic drugs have attracted considerable interest for OS, but they suffer from poor targeting, low bioavailability, severe side effects, multi-drug resistance acquired by tumor. Therefore, it imperative to develop novel therapeutic tactics that can improve outcomes while minimizing toxicity. Bioinspired nanoparticles, designed through exploiting or simulating biological structures processes, provide promising strategies OS. In this review, we elaborate on properties biomedical applications state-of-the-art bioinspired including cell membrane-based exosome-based protein template-based peptide nanoparticles management
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2023, Номер 11(10), С. 2740 - 2740
Опубликована: Окт. 10, 2023
Identifying and managing osteosarcoma pose significant challenges, especially in resource-constrained developing nations. Advanced diagnostic methods involve isolating the nucleus from cancer cells for comprehensive analysis. However, two main challenges persist: mitigating image noise during capture transmission of cellular sections, providing an efficient, accurate, cost-effective solution cell segmentation. To tackle these issues, we introduce Twin-Self Cross-Attention Vision Transformer (TSCA-ViT). This pioneering AI-based system employs a directed filtering algorithm reduction features innovative transformer architecture with twin attention mechanism effective The model also incorporates cross-attention-enabled skip connections to augment spatial information. We evaluated our method on dataset 1000 pathology slide images Second People’s Hospital Huaihua, achieving remarkable average precision 97.7%. performance surpasses traditional methodologies. Furthermore, TSCA-ViT offers enhanced computational efficiency owing its fewer parameters, which results reduced time equipment costs. These findings underscore superior efficacy TSCA-ViT, offering promising approach addressing ongoing diagnosis treatment, particularly settings limited resources.
Язык: Английский
Процитировано
10
Current Organic Chemistry, Год журнала: 2024, Номер 28(15), С. 1190 - 1214
Опубликована: Май 15, 2024
Abstract: The usage of nanoparticles in tissue engineering applications has increased significantly the last several years. Functional tissues are developed by regulating cell proliferation, differentiation, and migration on nanostructured scaffolds containing cells. These provide an environment that is more structurally supportive than microarchitecture natural bone. Given its exceptional properties, such as osteogenic potential, biocompatibility, biodegradability, chitosan a good promising biomaterial. Unfortunately, chitosan's low mechanical strength makes it unsuitable for load-bearing applications. By mixing with other biomaterials, this drawback might be mitigated. Bone uses both bioresorbable materials like tricalcium phosphate bioactive hydroxyapatite bioglass. Alumina titanium examples bioinert part these bioceramics. When produced at nanoscale scales, have larger surface area better adhesion. This review paper will go into great detail bioinert, bioresorbable, nanoceramics-reinforced bone engineering.
Язык: Английский
Процитировано
2